SummaryBackground: Several tumour-like conditions of the soft tissues may be encountered in clinical practice, or when patients undergo radiologic examinations. Al-though advances in cross sectional imaging (ultra-sound, MDCT and MRI) play a pivotal role in the correct evaluation of tumour-like lesions, a system-atic approach is needed to achieve a definitive di-agnosis or limit the differential diagnosis. Clinical history, physical examination and anatomic loca-tion are of paramount importance. Methods: In this pictorial essay we review some of the most frequent benign soft tissue conditions which may be mistaken for malignancy and thus lead to need-less referrals, unnecessary biopsies and great anxi-ety to the patients and their carers. Level of evidence: IV.