Pseuduvarines A and B, Two New Cytotoxic Dioxoaporphine Alkaloids from Pseuduvaria rugosa

Abstract

Pseuduvarines A (1) and B (2), two new dioxoaporphine alkaloids with an amino moiety, were isolated from the stem bark of Pseuduvaria rugosa and their structures were elucidated by combination of 2D-NMR spectroscopic analysis. Pseuduvarines A (1) and B (2) showed cytotoxicity against MCF7, HepG2, and HL-60 (1: IC 50 , 0.9, 21.7, and Ͼ50.0 m mM, respectively, 2: IC 50 Ͼ50.0, 15.7, and 12.4 m mM, respectively).

Antiproliferative effect of alkaloidsviacell cycle arrest fromPseuduvaria rugosa

“…Recently, pseuduvarines A and B isolated from P. rugosa exhibited cytotoxicity against MCF-7, Hep G2, and HL-60 human cancer cell lines (Taha et al, 2011). In the present study, we examined the antiproliferative activity of the other two alkaloids isolated from leaves and twigs of P. rugosa, 1,2,3-trimethoxy-5-oxonoraporphine and ouregidione, on human leukemic cell lines.…”

A New Benzophenone C-Glucoside and Other Constituents of Pseuduvaria fragrans and Their α-Glucosidase Inhibitory Activity

“…Studies on Pseuduvaria indochinensis , P. macrophylla , P. monticola , P. rugose , P. setosa , and P. trimera, revealed prenylated benzopyrans and aporphine alkaloids as their major secondary metabolites [ 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 ]. The benzopyran derivatives from P. indochinensis and P. monticola [ 6 , 10 ], as well as the aporphine alkaloids from P. rugose , P. setosa , and P. trimera , exhibited in vitro cytotoxicity against cancer cells [ 12 , 13 , 14 , 15 ]. Recent in vivo experiments on the extracts prepared from Pseuduvaria macrophylla and P. montana disclosed their antidiabetic effects, which appeared to be mediated by upregulation of insulin secretion [ 8 , 11 ].…”

Cytotoxic Aporphine Alkaloids from Leaves and Twigs of Pseuduvaria trimera (Craib)

“…Previous work on plants of this genus have revealed the presence of alkaloids in every Pseuduvaria species investigated such as aporphine, 1,2,3-trimethoxy-4,5-dioxo-6a,7-dehydroaporphine and O -methylmoschatoline [3], N -methylouregidione, liriodenine, oxostephanine [4], pseuduvarines A and B [5], oxoanolobine [6] and 1,2,3-trimethoxy-5-oxonoraporphine (ouregidione) [4,7]. However, no phytochemical investigation of this plant species has been reported to date.…”