Psidium guajava leaves decrease arthritic symptoms  in adjuvant-induced arthritic rats

Baroroh, Hanif Nasiatul; Utami, Esti Dyah; Soeroso, Joewono

doi:10.18051/univmed.2015.v34.197-204

Cited by 6 publications

(5 citation statements)

References 17 publications

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“…The extract is a strong candidate to be developed as a phytopharmaceutical for antiarthritics based on the pharmacological investigation [1]. The safety of J. curcas leaves has been investigated in some toxicity studies.…”

Section: Discussionmentioning

confidence: 99%

“…The anti-inflammatory properties of J. curcas leaves have been demonstrated, and they can be used to treat arthritis. The results of previous studies showed that J. curcas leaves ethanolic extract (EJC) at doses of 150, 300, and 600 mg/kg BW effectively decreased the arthritic score in CFA (Complete Freund Adjuvant)induced arthritic rats [1]. The extract of J. curcas leaves that given orally also shown anti-inflammatory activity [2,3].…”

Section: Introductionmentioning

confidence: 99%

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Subacute toxicity study of Jatropha curcas leaves on hematology parameters and renal function in Wistar rats

Nasiatul BAROROH,

NURYANTI,

WARSINAH

2023

jrp

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The anti-inflammatory properties of Jatropha curcas leaves have been established. The Acute toxicity test showed that J. curcas leaves were safe. This study aimed to assess the safety of the ethanol extract of J. curcas (EJC) leaves on hematological indicators and renal function. In the present study, using 40 male and 40 female Wistar rats were conducted to evaluate subacute toxicity. The EJC leaves with doses of 150, 300, and 600 mg/kg BW, were given orally and repeated for 30 days. The result showed no mortality and no changes in red blood cells (RBC) and white blood cells after administration of EJC leaves, but it caused toxic gastrointestinal symptoms such as a dark and watery stool. The use of the EJC at a dose of 150 mg/kg BW was safe because there was no change in the serum creatinine level and only the tiniest number of dark-stools toxic symptoms was experienced. Histopathologically, the EJC caused necrosis and congestion at doses of 300 and 600 mg/kgBW, which suggests that renal toxicity has already occurred. In conclusion, the EJC leaves with a dose of 150 mg/kg BW were found to be safe on hematology parameters and renal function. In conclusion, the administration of EJC leaves at a dose of 150 mg/kg BW was proven to be safe for renal function and hematological parameters.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Subacute toxicity study of Jatropha curcas leaves on hematology parameters and renal function in Wistar rats

Nasiatul BAROROH,

NURYANTI,

WARSINAH

2023

jrp

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“…Senyawa tersebut bermanfaat sebagai anti bakteri, kandungan pada daun jambu biji lainnya seperti saponin, minyak atsiri, tanin, anti mutagenik, flavonoid, dan alkaloid. Daun jambu biji mempunyai banyak manfaat seperti anti mikrobial terhadap Bacillus cereus khususnya pada bakteri gram positif anaerob (Arima dan Danno, 2002dan Milyani, et al, 2012, anti diare (Ojewole et al, 2008), anti inflamasi dan anti alergi (Baroroh et al, 2015). Setyowati et al, (2014) juga melaporkan bahwa ekstrak daun jambu biji memiliki kemampuan sebagai anti bakteri pada konsentrasi 500-1100 ppm.…”

Section: Pendahuluanunclassified

Pengaruh Perendaman Daun Jambu Biji Kering (Psidium Guava L) Terhadap Kadar Protein, Vitamin A dan Sensori Tahu

Dewayani

Riswita

Harti

et al. 2019

GATJ

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Tahu merupakan makanan favorit masyarakat sehari-hari. Namun tahu hanya bertahan satu hari saja, sehingga dibutuhkan pengawet untuk memperpanjang masa simpan. Salah satu pengawet alami yang potensial adalah daun jambu biji. Tujuan penelitian ini adalah untuk mengetahui pengaruh perendaman daun jambu biji kering terhadap kadar protein, vitamin A dan sensori tahu. Penelitian ini dilaksanakan pada bulan April – Mei 2019, di Laboratorium pasca panen BPTP Sulawesi Selatan. Rancangan yang digunakan adalah rancangan acak lengkap dengan perlakuan lama perendaman selama 0 hari, 2 hari, 4 hari, 6 hari, 8 hari dan 10 hari dan masing-masing perlakuan diulang tiga kali. Hasil penelitian menunjukkan bahwa perendaman tahu ke dalam ekstrak daun jambu biji (Psidium guava L) tidak berpengaruh nyata terhadap kandungan protein tahu. Perendaman tahu ke dalam ekstrak daun jambu biji berpengaruh nyata terhadap kandungan vitamin A dan sensori tahu. Perlakuan terbaik adalah tahu yang direndam dalam ekstrak daun jambu biji selama 4 hari dengan kadar protein 10.31 %, vitamin A 168 %, warna 2,67 (agak suka), aroma 3.4 (agak suka), rasa 3.07 (agak suka) dan tekstur 2.93 (agak suka).

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“…Rheumatoid Arthritis (RA) is most commonly seen in adults over the age of 65, but it can also develop in children, teens, and younger adults [2]. Alternative methods to address RA, such as the consumption of medicinal plants are becoming popular [3].…”

Section: Introductionmentioning

confidence: 99%

Anti-Arthritis, Antioxidant and Anti - Inflammatory Potential of Ethanolic Extract of Guava Leaves on Rats Exposed to High Fat Diet and Freud Adjuvant

Chinatu,

Elekima,

Adeline

et al. 2023

JOCAMR

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Guava leaves (Psidium guajava) have been used traditionally for years to treat common ailments such as Diabetes, diarrhoea, and hypertension. This study was designed to determine the anti-arthritic, anti-inflammatory, and antioxidant effect of the ethanolic extract of guava leaf (Psidium guajava) on rats fed with a high-fat diet and induced arthritis using complete Freud Adjuvant. Seventy-two male and female albino rats were used in this study, the rats were grouped into 12 with 6 rats in each group, rats were fed a high-fat diet to cause hyperlipidaemia and induced rheumatoid arthritis by injecting 0.1ml of Complete Freund’s Adjuvant into their right hind paw. Group 1 was fed with normal feed and water, group 2 was made of healthy rats, fed with normal feed, water, and guava leaf extract, group 3 was fed with a high-fat diet and induced arthritis with complete Freund’s Adjuvant (CFA) and water, group 4 received dexamethasone (6.75 mg.kg-1 orally), and groups 5 to 12 received the extract at oral doses of 250 and 750 mg/kg, respectively for a period of 28days. ELISA technique was used to analyse the inflammatory markers, antioxidants; SOD, and MDA, while the lipid profile was on a spectrophotometer. The inflammatory markers TNF-α, IL-6, and C-reactive protein were significantly reduced in test subjects at p<0.05, HDL and SOD had no statically significant difference, while MDA was markedly reduced at p<0.05. This study demonstrates that Psidium guajava extract has significant anti-arthritic and lipid-lowering effects. Psidium guajava leaves can be developed into an alternative anti-arthritis and lipid-lowering treatment.

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Psidium guajava leaves decrease arthritic symptoms in adjuvant-induced arthritic rats

Abstract: BACKGROUNDGuava is an herbal with proven antioxidant and anti-inflammatory properties. The aim of this study was to investigate the anti-arthritic activity of the ethanol extract of Psidium gujava leaves (EEPG) against complete Freund's adjuvant (CFA) induced arthritis in rats.

Cited by 6 publications

References 17 publications

Subacute toxicity study of Jatropha curcas leaves on hematology parameters and renal function in Wistar rats

Subacute toxicity study of Jatropha curcas leaves on hematology parameters and renal function in Wistar rats

Pengaruh Perendaman Daun Jambu Biji Kering (Psidium Guava L) Terhadap Kadar Protein, Vitamin A dan Sensori Tahu

Anti-Arthritis, Antioxidant and Anti - Inflammatory Potential of Ethanolic Extract of Guava Leaves on Rats Exposed to High Fat Diet and Freud Adjuvant

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