Psilocybin’s Potential Mechanisms in the Treatment of Depression: A Systematic Review

Lee, H.; Tsang, Vivian WL; Chai, Brandon S.; Lin, M; Howard, Andrew; Uy, Christopher; Elefante, Julius

doi:10.1080/02791072.2023.2223195

Cited by 5 publications

(1 citation statement)

References 67 publications

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“…As a result, providing appropriate treatment for individuals suffering from TRD poses a challenge for modern medicine and improving treatment efficacy is being pursued through the investigation of drugs that are intensely studied for their effectiveness. Among such drugs are ketamine and psilocybin [29,30].…”

Section: Possibilities Of Using Psilocybin and Its Effectiveness In T...mentioning

confidence: 99%

Psilocybin - new remedy for patients with psychiatric disorders? Critical analysis of the current state of knowledge

Wąsik,

Tomaszuk,

Wojtuś

2023

J Educ Health Sport

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Introduction and purpose: Nowadays, when mental disorders are considered by the World Health Organisation as a global burden, the potential usage of psychedelic drugs as supportive therapy is gaining more attention worldwide. The aim of this paper is to summarize the usefulness of psilocybin - representative of psychedelics - in psychiatric venues. In this review we describe its properties, efficacy and adverse events in treating depression, trauma and obsessive-compulsive disorders. Brief description of the state of knowledge: Psilocybin demonstrates a safety profile which does not differ from standard drugs used in therapies of psychiatric disorders. Positive results of its administration were noticed on different psychiatric scales and are considered as clinically meaningful. With depression being the most common mental disease and growing demand for new remedies, most of the conducted research is concentrated on this subject, but there is also some evidence of its purpose in the treatment of trauma and obsessive-compulsive disorders. Conclusions: Psilocybin merits further research as foregoing results of conducted studies are pointing to its efficacy. Psychedelic-assisted therapies may create noteworthy opportunities to current matter in the standard treatment of psychiatric disorders and there is a possibility that in the future in some cases they will be considered as the first line treatment. Nevertheless, still more data is needed to determine its placement in the treatments.

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Section: Possibilities Of Using Psilocybin and Its Effectiveness In T...mentioning

confidence: 99%

Psilocybin - new remedy for patients with psychiatric disorders? Critical analysis of the current state of knowledge

Wąsik,

Tomaszuk,

Wojtuś

2023

J Educ Health Sport

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Advances in Psychedelic Therapeutics: Novel Prodrugs and Derivatives for Enhanced Mental Health Treatment

Kargbo

2024

ACS Med. Chem. Lett.

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Recent innovations in psychedelic research have led to the development of novel compounds designed to enhance the therapeutic potential of psilocin and related tryptamines. This Patent Highlight reviews three essential patents that focus on improving the stability, bioavailability, and efficacy of these compounds for treating mental health disorders such as depression, anxiety, and substance use disorders. The compounds�4-pivaloyloxy-N-methyltryptammonium chloride, alkyl quaternary ammonium tryptamines, and 4-pivaloyloxy-N-methyltryptammonium derivatives�represent significant advancements in the field of psychedelic-assisted therapy. These innovations offer new hope for more reliable and effective treatments, particularly in addressing the limitations associated with traditional psychedelics. The findings from preclinical studies support the potential of these compounds to play a vital role in the treatment of mental and neurological disorders.

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Advances in Psychoactive Alkaloid Delivery, Ergoline Analogues, and Serotonin Receptor Modulation for Enhanced Therapeutic Outcomes

Kargbo

2024

ACS Med. Chem. Lett.

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Psilocybin’s Potential Mechanisms in the Treatment of Depression: A Systematic Review

Cited by 5 publications

References 67 publications

Psilocybin - new remedy for patients with psychiatric disorders? Critical analysis of the current state of knowledge

Psilocybin - new remedy for patients with psychiatric disorders? Critical analysis of the current state of knowledge

Advances in Psychedelic Therapeutics: Novel Prodrugs and Derivatives for Enhanced Mental Health Treatment

Advances in Psychoactive Alkaloid Delivery, Ergoline Analogues, and Serotonin Receptor Modulation for Enhanced Therapeutic Outcomes

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