Psittacosis Presenting as a Halo Sign on High-resolution Computed Tomography

Hochhegger, Bruno; Marchiori, Edson; Irion, Klaus; Melo, Gustavo Santos de; Mendes, Fernanda de Souza Nogueira Sardinha; Zanetti, Gláucia

doi:10.1097/rti.0b013e318191987e

Cited by 11 publications

(5 citation statements)

References 8 publications

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“…Besides, lesions could occur in any lobe, mainly in the inferior lobe and unilateral lung, particularly the right lung, and hilar lymphadenectasis was uncommon. [19][20][21][22] Broadly consistent but slightly different, lesions tended to occur in the left lung inferior lobe in our study, which may be related to small sample size. In addition, we also found that the early-stage lesions were small in scope and more common in the subpleura.…”

Section: Discussionsupporting

confidence: 50%

“…Studies have shown that the radiographic features of C. psittaci pneumonia were mainly patchy consolidation shadows or ground‐glass density shadows, bronchiectasis, involvement in one or both lungs, inflammatory effusion of one or more lobes and partial pleural effusion. Besides, lesions could occur in any lobe, mainly in the inferior lobe and unilateral lung, particularly the right lung, and hilar lymphadenectasis was uncommon 19–22 . Broadly consistent but slightly different, lesions tended to occur in the left lung inferior lobe in our study, which may be related to small sample size.…”

Section: Discussionsupporting

confidence: 40%

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Clinical features and outcome of eight patients with Chlamydia psittaci pneumonia diagnosed by targeted next generation sequencing

Zhang

Jiang

et al. 2023

Clinical Respiratory J

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IntroductionThe clinical symptoms of Chlamydia psittaci pneumonia are still poorly understood. This study was designed to summarize the clinical features and outcome of eight C. psittaci pneumonia patients diagnosed by targeted next generation sequencing (tNGS).MethodsWe included eight C. psittaci pneumonia patients admitted to our hospital from January 2021 to July 2022. The tNGS was performed to the samples collected from bronchoalveolar lavage fluid of each patient. Their clinical data were analysed, including baseline features, clinical symptoms, chest radiographic findings and laboratory examinations.ResultsThe tNGS sequence number for C. psittaci was in a range of 10 to 1722. The radiographic characteristics were mainly featured by patchy consolidation shadows, ground‐glass density shadows, air bronchogram and slight pleural effusion. Within 1–3 days after hospitalization, most patients showed increased neutrophil ratio, C‐reactive protein and erythrocyte sedimentation rate, and decreased lymphocyte count, total protein, albumin and prealbumin. Some patients showed increased glutamic‐pyruvic transaminase, glutamic‐oxaloacetic transaminase and lactate dehydrogenase levels. Three critically ill patients showed increased creatine kinase, creatine kinase isoenzyme and high‐sensitivity troponin T (hs‐TnT) levels.ConclusionsA poultry or bird contact history, typical flu‐like symptoms, patchy consolidation, ground‐glass density shadow and air bronchogram may contribute to the diagnosis and treatment of C. psittaci pneumonia. Increase in creatine kinase, creatine kinase isoenzyme and hs‐TnT may indicate a severe condition. Moxifloxacin and minocycline were effective in the management of C. psittaci pneumonia.

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Section: Discussionsupporting

confidence: 50%

Section: Discussionsupporting

confidence: 40%

Clinical features and outcome of eight patients with Chlamydia psittaci pneumonia diagnosed by targeted next generation sequencing

Zhang

Jiang

et al. 2023

Clinical Respiratory J

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“…In these cases, only two patients had normal chest imaging. High-resolution CT shows that some lesion areas are solid nodular and ground glass [22]. Among the two cases we have reported, there were solid or ground glass pulmonary shadows, and hilar lymphadenopathy and pleural effusion in case 2.…”

Section: Discussionmentioning

confidence: 75%

Severe pneumonia caused by Chlamydia psittaci: report of two cases and literature review

Dai

Geng

et al. 2022

J Infect Dev Ctries

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Introduction: Chlamydia psittaci pneumonia is a zoonotic infectious disease caused by Chlamydia psittaci. Its clinical manifestations are nonspecific. Diagnosis of the disease is difficult. In recent years, next-generation sequencing has played an important role in pathogen detection. We report two cases with severe Chlamydia psittaci pneumonia confirmed by next-generation sequencing. Case Study: The first case is that of a 50-year old man who presented with high fever for four days and cough with sputum for two days. The second case is that of a 57-year-old man who was admitted with high fever for one week, dyspnea and cough with sputum for four days. The second man worked at a chicken farm in the last two months. In both cases, the usual laboratory examination for pathogens detection was negative, and the initial anti-infectious therapy had limited effect. The bronchoalveolar lavage fluid of case 1 and the blood and sputum of case 2 were sent for next-generation sequencing which resulted in sequence reads of Chlamydia psittaci. Antibiotics were adjusted according to the diagnosis. Results: The diagnosis of the two cases was confirmed by next-generation sequencing detecting Chlamydia psittaci, and the patients had positive results after treatment. Conclusions: The two cases suggest that next-generation sequencing could be used in early diagnosis of Chlamydia psittaci infection to initiate specific anti-infection therapy in time.

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“… 9 , 27 , 28 Seventy percent of these patients have pleural effusion manifestations, which are directly proportional to the severity of the disease, and severe pneumonia may present with bilateral pleural effusion. Hochhegger et al 29 proposed that chest CT in psittacine pneumonia can present as nodular shadows in both lower lungs or peripheral halo signs, but imaging diagnosis always lacks specificity. It can be combined with medical history, laboratory tests, and clinical manifestations, but the final diagnosis depends on etiology.…”

Section: Diagnostic Techniquesmentioning

confidence: 99%

Psittacosis Pneumonia: Diagnosis, Treatment and Interhuman Transmission

Cui¹,

Meng²

2023

IJGM

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Psittacosis pneumonia is a zoonosis caused by Chlamydia psittacosis infection, mainly resulting from contact with aerosols of birds or poultry’s urine, feces, and excrement. The clinical manifestations range from general symptoms of infection to severe acute respiratory syndrome and systemic diseases, currently diagnosed using metagenomic next-generation sequencing (mNGS) to improve diagnostic accuracy. To date, most reports have only discussed human exposure to poultry disease. However, the latest studies have shown that human-to-human transmission of Chlamydia psittaci occurs not only between infected patients and their close contacts but also between secondary contacts. After looking back on relevant literature at home and abroad in the past ten years, this paper reviews the diagnosis, diagnosis and treatment, and progress in epidemiological research of Psittacosis pneumonia.

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Psittacosis Presenting as a Halo Sign on High-resolution Computed Tomography

Cited by 11 publications

References 8 publications

Clinical features and outcome of eight patients with Chlamydia psittaci pneumonia diagnosed by targeted next generation sequencing

Clinical features and outcome of eight patients with Chlamydia psittaci pneumonia diagnosed by targeted next generation sequencing

Severe pneumonia caused by Chlamydia psittaci: report of two cases and literature review

Psittacosis Pneumonia: Diagnosis, Treatment and Interhuman Transmission

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