Multilevel inverters are powerful electronic devices that are used for the conversion of DC input voltage into AC output voltage and mostly used in medium and high voltage operations. In these operations, pulse width modulation (PWM) frequency is distorted because of electromagnetic interference (EMI) and switching losses which are caused by dv/dt stress. To achieve a pure sinusoidal waveform at output of multilevel inverter is a primary purpose so that a smaller number of harmonic contents are produced. Selective harmonic elimination PWM technique is used in cascaded multilevel inverter for the mitigation of lower harmonics by solving nonlinear transcendental equations and maintains the required fundamental voltage. An objective function is derived from SHE problem to calculate switching angles. For the solution of objective function, optimization approach such as bio-inspired intelligent algorithms are used. In this paper, Genetic Algorithm (GA), Particle Swarm Optimization (PSO) and Bee Algorithm (BA) are used to determine the optimum switching angles for cascaded multilevel inverters to get low total harmonic distortion (THD) in output voltage. These computed angles are analyzed in MATLAB simulation model to authenticate the results. And there will be direct comparison among these algorithms.