Psoralea corylifolia L.: Panacea to several maladies

Mahajan, Neha; Koul, Bhupendra; Gupta, Pankaj; Shah, Bhahwal Ali; Singh, Joginder

doi:10.1016/j.sajb.2022.01.024

Cited by 8 publications

(4 citation statements)

References 175 publications

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“…P. corylifolia , often referred to as the “ageless herb,” is among the most utilized Chinese herbal medicines. Its geographic range extends across India, China, Pakistan, Bangladesh, Nepal, Sri Lanka and Myanmar (Zhao et al., 2005; Mahajan et al., 2022). This versatile plant thrives in diverse habitats, including grasslands, meadows, thickets, and mountain slopes at altitudes ranging from 500 to 2000 m. P. corylifolia prefers warm, humid climate and thrives in sunny, flat environments with ample sunlight.…”

Section: Resourcesmentioning

confidence: 99%

Advances on resources, biosynthesis pathway, bioavailability, bioactivity, and application of corylifolinin

Chen,

Li,

Hussain

et al. 2024

Future Postharvest and Food

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Corylifolinin, also known as isobavachalcone, is a flavonoid compound isolated from the seeds of Psoralea corylifolia L. With a rich array of biological activities, corylifolinin has emerged as a versatile therapeutic agent. It has demonstrated notable antioxidant, anti‐inflammatory, anti‐tumor, anti‐bacterial, and anti‐viral properties. Moreover, corylifolinin holds promise in enhancing liver function, cardiovascular health, and providing neuroprotection. Its applications span a range of medical conditions, including hepatitis, cardiovascular disease, tumors, and inflammation. Herein, this comprehensive review delves into various aspects of corylifolinin, encompassing its sources, biosynthetic pathways, biotransformation, physicochemical properties, absorption, assimilation, metabolism, and excretion. It explores the molecular mechanisms underlying its diverse bioactivities in cellular and animal models. Furthermore, we present insights into clinical trials, human studies, toxicological profiles, safety considerations, marketed products, and patents related to corylifolinin. This compilation aims to serve as a valuable reference for both the development and clinical application of corylifolinin‐based therapies.

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Section: Resourcesmentioning

confidence: 99%

Advances on resources, biosynthesis pathway, bioavailability, bioactivity, and application of corylifolinin

Chen,

Li,

Hussain

et al. 2024

Future Postharvest and Food

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“…The source of bakuchiol varies between regions; it is commonly extracted from the seeds and leaves of Psoralea corylifolia (Babchi plant) in India, which belongs to the Leguminosae plant family, and is a major phytochemical present in the root and stem of Ulmus davidiana var. 17 Japonica (Japanese Elm) is widely distributed in China, Japan, and Korea. 6 These plants have been used in their regions of wide distribution in traditional medicine to treat inflammatory disorders and cancer.…”

Section: Introductionmentioning

confidence: 99%

Bakuchiol and its pharmacological benefits

et al. 2023

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Background and aims: Natural compounds extracted from medicinal plants have recently gained attention in therapeutics as they are considered to have lower toxicity and higher tolerability relative to chemically synthesized compounds. Bakuchiol is one such compound; it is a type of meroterpene derived from the leaves and seeds of Psoralea corylifolia plants. Natural sources of bakuchiol have been used in traditional Chinese and Indian medicine for centuries due to its preventive benefits against tumors and inflammation. It plays a strong potential role as an antioxidant with impressive abilities to remove Reactive Oxygen Species (ROS). This review has focused on bakuchiol's extraction, therapeutic applications, and pharmacological benefits. Methods: A search strategy has been followed to retrieve the relevant newly published literature on the pharmacological benefits of bakuchiol. After an extensive study of the retrieved articles and maintaining the inclusion and exclusion criteria, 106 articles were finally selected for this review. Results: Strong support of primary research on the protective effects via antitumorigenic, anti-inflammatory, antioxidative, antimicrobial, and antiviral activities are delineated. Conclusions: From ancient to modern life, medicinal plants have always been drawing the attention of human beings to alleviate ailments for a healthy and balanced lifestyle. This review is a comprehensive approach to highlighting bona fide essential pharmacological benefits and mechanism of action of therapeutic implications.

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Section: Introductionmentioning

confidence: 99%

“…Piper longum (Long pepper), Psoralea glandulosa L, Otholobium pubescens, Prosopis glandulosa, Aerva sanguinolenta, Psoralidium tenuiflorum, Pimelea drupacea, Bridelia retusa, Spiraea formosana, Elaeagnus bockii and other sources of bakuchiol have been discovered in recent times. [17][18][19][20] Medicinal plants e.g. : Psoralea corylifolia where bakuchiol is derived have been used directly as traditional medication or via pharmaceutical preparations in modern medicine.…”

Section: Introductionmentioning

confidence: 99%

Bakuchiol, a natural constituent and its pharmacological benefits

Nizam,

Mahmud,

Ark

et al. 2023

F1000Res

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Background and aims Natural compounds extracted from medicinal plants have recently gained attention in therapeutics as they are considered to have lower Toxicity and higher tolerability relative to chemically synthesized compounds. Bakuchiol from Psoralea corylifolia L. is one such compound; it is a type of meroterpene derived from the leaves and seeds of Psoralea corylifolia plants. Natural sources of bakuchiol have been used in traditional Chinese and Indian medicine for centuries due to its preventive benefits against tumors and inflammation. It plays a strong potential role as an antioxidant with impressive abilities to remove Reactive Oxygen Species (ROS). This review has focused on bakuchiol’s extraction, therapeutic applications, and pharmacological benefits. Methods A search strategy has been followed to retrieve the relevant newly published literature on the pharmacological benefits of bakuchiol. After an extensive study of the retrieved articles and maintaining the inclusion and exclusion criteria, 110 articles were finally selected for this review. Results Strong support of primary research on the protective effects via antitumorigenic, anti-inflammatory, antioxidative, antimicrobial, and antiviral activities are delineated. Conclusions From ancient to modern life, medicinal plants have always been drawing the attention of human beings to alleviate ailments for a healthy and balanced lifestyle. This review is a comprehensive approach to highlighting bona fide essential pharmacological benefits and mechanisms underlying their therapeutic applications.

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Psoralea corylifolia L.: Panacea to several maladies

Cited by 8 publications

References 175 publications

Advances on resources, biosynthesis pathway, bioavailability, bioactivity, and application of corylifolinin

Advances on resources, biosynthesis pathway, bioavailability, bioactivity, and application of corylifolinin

Bakuchiol and its pharmacological benefits

Bakuchiol, a natural constituent and its pharmacological benefits

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