Psoralen and long wavelength ultraviolet radiation as an adjuvant therapy for prevention of intimal hyperplasia and constrictive remodeling after balloon dilation: A study in the rabbit iliac artery

Perree, Jop; Leeuwen, Ton G. van; Velema, Evelyn; Borst, Cornelius

doi:10.1002/(sici)1096-9101(1998)23:5<281::aid-lsm8>3.0.co;2-t

Cited by 4 publications

(6 citation statements)

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“…The angiographic LL, after 6 weeks of survival, comprised contributions from both IH and arterial shrinkage as described previously (2,14,19,20). Because IH accounted for only a limited fraction (20–40%) of the LL and was comparable for PTA and PUVB, the reduction in LL was almost entirely because of an inhibition of arterial shrinkage (PTA vs PUVB: 0.53 mm vs 0.15 mm).…”

Section: Discussionmentioning

confidence: 99%

“…At the end of the experiment, a blood sample was taken (approximately 40 min after the start of 8-MOP infusion), and 8-MOP infusion was stopped. Subsequently, the 8-MOP serum concentration was assessed as described previously (14).…”

Section: Methodsmentioning

confidence: 99%

“…We have previously tested the effectiveness of 8‐methoxypsoralen (8‐MOP) activated by long‐wave UV light (ultraviolet light A [UVA]; λ= 355–365 nm) (8‐MOP + UVA [PUVA]) for preventing luminal narrowing after balloon dilation in rabbit iliac arteries after 4 weeks of survival (14). However, PUVA applied at the time of intervention led to an even smaller lumen because of the enhancement of constrictive remodeling (14). In contrast, the 308 nm UVB band emanating from the excimer laser is absorbed about 10 times better by 8‐MOP than the 355–365 nm UVA bands.…”

Section: Introductionmentioning

confidence: 99%

“…Fifteen healthy Elco rabbits (RIVM, Bilthoven, The Netherlands) were used in this study. The injury procedure was performed as previously described (14). Briefly, rabbits were anesthetized and a 5 F sheath was introduced into the right carotid artery.…”

mentioning

confidence: 99%

“…Subsequently, a modified (14) 3.0 mm diameter, 25 mm length percutaneous transluminal angioplasty (PTA) balloon catheter (Fig. 1) (SciMed Life Systems, Minneapolis, MN) was advanced under fluoroscopy into the iliac artery, and the balloon was positioned relative to an angiographic landmark.…”

mentioning

confidence: 99%

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UVB-activated Psoralen Reduces Luminal Narrowing After Balloon Dilation Because of Inhibition of Constrictive Remodeling¶

Perree¹,

Leeuwen²,

Velema³

et al. 2007

Photochemistry and Photobiology

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In this study we have explored the potential of PUVB (8‐MOP + UVB) therapy for the reduction of luminal narrowing after arterial injury. In 15 rabbits, balloon dilation of iliac arteries was performed. In 20 arteries, dilation was combined with the delivery of pulsed ultraviolet light B (UVB) irradiation with 10 arteries being previously subjected to sensitizer infusion. Changes in vessel diameter, proliferation and extracellular matrix protein content at 6 weeks were evaluated by means of angiography and histomorphometry–immunohistochemistry. We found that PUVB, applied at the time of dilation, induced reduction in late loss (LL) at 6 weeks (percutaneous transluminal angioplasty vs UVB vs PUVB: 0.64 ± 0.15 mm vs 0.61 ± 0.05 mm vs 0.29 ± 0.05 mm; p= 0.018). The same holds true for constrictive remodeling (0.53 ± 0.15 mm vs 0.45 ± 0.06 mm vs 0.15 ± 0.05 mm; p= 0.016). In the irradiation groups, LL was independent of acute gain (AG), as opposed to the control. Collagen content increased significantly after PUVB in media and adventitia, without increased cellular proliferation in all vessel layers. Thus, PUVB at the time of dilation reduced luminal narrowing at follow‐up without effecting proliferation. This effect was independent of AG and was associated with increased collagen content in media and adventitia.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%