Psoralen reverses docetaxel-induced multidrug resistance in A549/D16 human lung cancer cells lines

Hsieh, Ming‐Ju; Chen, Mu‐Kuan; Yu, Ya-Yen; Sheu, Gwo‐Tarng; Chiou, Hui‐Ling

doi:10.1016/j.phymed.2014.03.008

Cited by 46 publications

(31 citation statements)

References 27 publications

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“…21 In this study, we extended the time period and obtained different results. We detected the intracellular fluorescence intensity of PAMAM-NH 2 at different times (1,3,6,9,12,18, and 24 hours) after its removal. As shown in Figure 9A, the exocytosis of PAMAM-NH 2 in the MCF-7 cells reached a maximum at 3 hours.…”

Section: Exocytosis Of Pamam Dendrimersmentioning

confidence: 99%

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The cellular uptake mechanism, intracellular transportation, and exocytosis of polyamidoamine dendrimers in multidrug-resistant breast cancer cells

Zhang¹,

Liú²,

Zhang³

et al. 2016

IJN

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Polyamidoamine dendrimers, which can deliver drugs and genetic materials to resistant cells, are attracting increased research attention, but their transportation behavior in resistant cells remains unclear. In this paper, we performed a systematic analysis of the cellular uptake, intracellular transportation, and efflux of PAMAM-NH 2 dendrimers in multidrug-resistant breast cancer cells (MCF-7/ADR cells) using sensitive breast cancer cells (MCF-7 cells) as the control. We found that the uptake rate of PAMAM-NH 2 was much lower and exocytosis of PAMAM-NH 2 was much greater in MCF-7/ADR cells than in MCF-7 cells due to the elimination of PAMAM-NH 2 from P-glycoprotein and the multidrug resistance-associated protein in MCF-7/ADR cells. Macropinocytosis played a more important role in its uptake in MCF-7/ADR cells than in MCF-7 cells. PAMAM-NH 2 aggregated and became more degraded in the lysosomal vesicles of the MCF-7/ADR cells than in those of the MCF-7 cells. The endoplasmic reticulum and Golgi complex were found to participate in the exocytosis rather than endocytosis process of PAMAM-NH 2 in both types of cells. Our findings clearly showed the intracellular transportation process of PAMAM-NH 2 in MCF-7/ADR cells and provided a guide of using PAMAM-NH 2 as a drug and gene vector in resistant cells.

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Section: Exocytosis Of Pamam Dendrimersmentioning

confidence: 99%

“…For the treatment of cases of inoperable and advanced-stage cancer, chemotherapy has been the optimal treatment choice. 1 However, the major obstacle to successful chemotherapy for cancer treatment is multidrug resistance (MDR) in tumor cells. Considerable research effort has been devoted to overcome the MDR.…”

Section: Introductionmentioning

confidence: 99%

The cellular uptake mechanism, intracellular transportation, and exocytosis of polyamidoamine dendrimers in multidrug-resistant breast cancer cells

Zhang¹,

Liú²,

Zhang³

et al. 2016

IJN

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“…Psoralen was a natural product possessing cartilage protecting [7], antitumor [8, 9], immunomodulatory [10], antivitiligo [11], and antiurticaria activities [12]. It was commonly used in combination with UVA to form a phototherapy, called psoralen plus ultraviolet A (PUVA), to treat cancers.…”

Section: Discussionmentioning

confidence: 99%

Psoralen Inhibited Apoptosis of Osteoporotic Osteoblasts by Modulating IRE1-ASK1-JNK Pathway

Chen

Wang

Yang

et al. 2017

BioMed Research International

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Osteoporosis is a common disease causing fracture in older populations. Abnormal apoptosis of osteoblasts contributes to the genesis of osteoporosis. Inhibiting apoptosis of osteoblasts provides a promising strategy to prevent osteoporosis. The proliferation of osteoblasts isolated from osteoporotic patients or healthy subjects was determined by MTT assay. Apoptosis was determined by Annexin V/PI assay. Protein expression was measured by western blot. The proliferation of osteoblasts isolated from osteoporotic patients was inhibited and the apoptosis level of these cells was higher than the osteoblasts from healthy subjects. Incubation with psoralen or estradiol significantly enhanced the proliferation and decreased the apoptosis level of osteoporotic osteoblasts. Western blot demonstrated that psoralen or estradiol treatment downregulated the expression of IRE1, p-ASK, p-JNK, and Bax. Meanwhile, expression of Bcl-2 was upregulated. Pretreatment by IRE1 agonist tunicamycin or JNK agonist anisomycin attenuated the effect of psoralen on osteoporotic osteoblasts. Psoralen inhibited apoptosis of osteoporotic osteoblasts by regulating IRE1-ASK1-JNK pathway.

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“…The benzofuran derivatives are naturally occurring and possess many biological applications [1][2][3]. Angelicin, Psoralen and bergapten are the examples of naturally occurring benzofuran derivatives with biological applications [4][5][6] (Fig. 1).…”

Section: Introductionmentioning

confidence: 99%

Synthesis and biological evaluation of new benzofuran carboxamide derivatives

Lavanya

Sribalan

Padmini

2017

Journal of Saudi Chemical Society

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A series of new 3-(glycinamido)-benzofuran-2-carboxamide and 3-(b-alanamido)-benzo furan-2-carboxamide derivatives (5a-o) were synthesized for the purpose of developing the new bioactive chemical entities and evaluated for their in vitro antimicrobial, anti-inflammatory and DPPH radical scavenging activities. The synthesized compounds were characterized by NMR, IR, Mass and X-ray crystallographic techniques. ª 2015 Production and hosting by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Psoralen reverses docetaxel-induced multidrug resistance in A549/D16 human lung cancer cells lines

Cited by 46 publications

References 27 publications

The cellular uptake mechanism, intracellular transportation, and exocytosis of polyamidoamine dendrimers in multidrug-resistant breast cancer cells

The cellular uptake mechanism, intracellular transportation, and exocytosis of polyamidoamine dendrimers in multidrug-resistant breast cancer cells

Psoralen Inhibited Apoptosis of Osteoporotic Osteoblasts by Modulating IRE1-ASK1-JNK Pathway

Synthesis and biological evaluation of new benzofuran carboxamide derivatives

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