Psoralen-ultraviolet A therapy alters epidermal Sema3A and NGF levels and modulates epidermal innervation in atopic dermatitis

Tominaga, Mitsutoshi; Tengara, Suhandy; Kamo, Atsuko; Ogawa, Hideoki; Takamori, Kenji

doi:10.1016/j.jdermsci.2009.03.007

Cited by 115 publications

(107 citation statements)

References 42 publications

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“…64) the UVbased therapies were shown to reduce the number of cutaneous nerve fibers, especially in the epidermis, in patients with atopic dermatitis and psoriasis, and to inhibit pruritus. 65,66) Similar effects of UV-based therapy on epidermal nerve fibers were observed in dry skin mice. 36) the imbalance between Sema3A and nGf levels in the epidermis was normalized by PUVA or narrow-band UVb treatment.…”

Section: Uv-based Therapymentioning

confidence: 61%

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An Update on Peripheral Mechanisms and Treatments of Itch

Tominaga

Takamori

2013

Biological & Pharmaceutical Bulletin

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Histamine H 1 -receptor blockers are used to treat all types of itch resulting from serious skin diseases such as atopic dermatitis, as well as from renal and liver diseases. However, they often lack efficacy in chronic itch, a profound clinical problem that decreases quality of life. The development of effective treatments requires a full understanding of the fundamental mechanisms of itch. Recent studies have indicated that the pathogenic mechanisms of itch also involve agonists other than histamine, including proteases, neuropeptides, cytokines, and opioids, as well as their cognate receptors. Release of these pruritogenic mediators and modulators into the periphery may directly activate itch-mediating C-fibers via specific receptors on the nerve terminals. Histological observations have shown increased epidermal nerve densities in patients with atopic dermatitis, suggesting that the higher density is at least partly responsible for itch sensitization. This

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Section: Uv-based Therapymentioning

confidence: 61%

“…36) the imbalance between Sema3A and nGf levels in the epidermis was normalized by PUVA or narrow-band UVb treatment. 36,66) A recent study showed that excimer lamp treatment was the most effective form of UV-based therapy for intraepidermal nerve fibers. 36) …”

Section: Uv-based Therapymentioning

confidence: 99%

An Update on Peripheral Mechanisms and Treatments of Itch

Tominaga

Takamori

2013

Biological & Pharmaceutical Bulletin

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“…Following PUVA treatment, Sema3A upregulation and NGF downregulation were observed in the epidermis of AD patients (Figure 11). These patients also showed decreases in VAS for itching and clinical severity scores, concomitant with decreases in epidermal nerve densities (Figure 12) (Tominaga et al, 2009c). Sema3A inhibits NGF-induced sprouting of sensory afferents in the adult rat spinal cord (Dontchev and Letourneau, 2002).…”

Section: Uv-based Therapy Of Ad Pruritus Involving Epidermal Hyperinnmentioning

confidence: 92%

“…We hypothesized that epidermal Sema3A and NGF levels in AD patients are influenced by PUVA therapy, resulting in decreased epidermal nerve density in atopic skin. Using skin biopsies, we recently showed that PUVA therapy reduces epidermal hyperinnervation in AD patients by normalizing abnormal epidermal Sema3A and NGF expression (Tominaga et al, 2009c). Following PUVA treatment, Sema3A upregulation and NGF downregulation were observed in the epidermis of AD patients (Figure 11).…”

Section: Uv-based Therapy Of Ad Pruritus Involving Epidermal Hyperinnmentioning

confidence: 97%

“…8.1 Effects of PUVA therapy on epidermal nerve fibers NGF levels are higher, and Sema3A levels are lower, in the epidermis of patients with AD than in controls, suggesting that abnormal levels of axonal guidance molecules are involved in epidermal hyperinnervation in AD (Tominaga et al, 2008;Tominaga et al, 2009c). We hypothesized that epidermal Sema3A and NGF levels in AD patients are influenced by PUVA therapy, resulting in decreased epidermal nerve density in atopic skin.…”

Section: Uv-based Therapy Of Ad Pruritus Involving Epidermal Hyperinnmentioning

confidence: 99%

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