Psoralidin, a coumestan analogue, as a novel potent estrogen receptor signaling molecule isolated from Psoralea corylifolia

Liu, Xiyuan; Nam, Joo Won; Song, Yun Seon; Viswanath, Ambily Nath Indu; Pae, Ae Nim; Kil, Yun Seo; Kim, Hee Doo; Park, Jong Hoon; Seo, Eun Kyoung; Chang, Min-Sun

doi:10.1016/j.bmcl.2014.01.029

Cited by 53 publications

(26 citation statements)

References 17 publications

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“…On the other hand, ERα agonists might facilitate bone protecting properties. These outcomes of experiments supported the traditional use of P. corylifolia , L. in the treatment of osteoporosis or postmenopausal conditions (Liu et al, ). A bioactivity guided isolation study on P. corylifolia showed that methanol extract and subsequent isolated compounds, including monoterpenes, isoflavones, and coumestan have estrogenic activities, and bakuchiol being the most effective ER agonist.…”

Section: Biological Activitiessupporting

confidence: 57%

“…Dioxane extract of seeds showed maximum activity against the pathogens tested (Chanda, Kaneria, & Nair, ). Similarly, the compound bakuchiol (MIC 0.037 and 0.018 mM against S. areus and S. epidermdis, respectively (Liu et al, ; Park, Zhao, Kim, & Sohn, ; Seo et al, ), along with other related compounds that possess potent antibacterial activity (Pavela, ).…”

Section: Biological Activitiesmentioning

confidence: 99%

“…It was observed that activation of the classical ER‐signaling pathway by psoralidin is mediated via induction of ER conformation by psoralidin and direct binding of the psoralidin–ER complex of the EREs present in the promoter region of estrogen‐responsive genes. Lastly, molecular docking of psoralidin to the ligand‐binding pocket of the ERα exposed that psoralidin is able to mimic the binding interactions of E 2 , and therefore, in the cellular environment it could act as an ER agonist (Liu et al, ).…”

Section: Biological Activitiesmentioning

confidence: 99%

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Psoralea corylifolia L: Ethnobotanical, biological, and chemical aspects: A review

Alam

Khan

Asad

2017

Phytotherapy Research

139

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Psoralea corylifolia L. (Leguminosae) is a well-known traditional medicinal plant used from ancient times for treatment of various ailments. It is widely distributed and an important part of therapeutics in Ayurveda and in Chinese medicines. The aim of this review is to present comprehensive and most up to date report on its ethnobotanical, ethnopharmacological, clinical, phytochemical, and side effects. Studies on the ethnobotanical, ethnopharmacological, clinical, phytochemical, and side effects of P. corylifolia were published until year 2017 and were searched using various scientific databases. The scientific literature searched revealed that these plant species has been extensively investigated in vivo and in vitro for various biological and phytochemical studies. It has cardiotonic, vasodilator, pigmentor, antitumor, antibacterial, cytotoxic, and anti-helminthic properties and locally used for alopecia, inflammation, leukoderma, leprosy, psoriasis, and eczema. So far, about a hundred bioactive compounds have been isolated from seeds and fruits, and most important compounds identified belongs to coumarins, flavonoids, and meroterpenes groups. This review article summarized the most updated scientific literature on bioactive phytochemical and biological activities of P. corylifolia. This article will be a useful addition to providing information for future research, and more standard clinical trials are needed for the plant to be used as therapeutic agent.

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Section: Biological Activitiessupporting

confidence: 57%

Section: Biological Activitiesmentioning

confidence: 99%

Section: Biological Activitiesmentioning

confidence: 99%

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Psoralea corylifolia L: Ethnobotanical, biological, and chemical aspects: A review

Alam

Khan

Asad

2017

Phytotherapy Research

139

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“…It also showed inhibitory effects on protein tyrosine phosphatase 1B in vitro (Kim et al, 2005), induction of quinone reductase activity (Lee, Nam & Mar, 2009), and inhibitory effects on LPS-induced iNOS expression (Chiou et al, 2011). Furthermore, it was found that PSO could act as an ER agonist (Liu et al, 2014) and was a dual inhibitor of COX-2 and 5-LOX (Yang et al, 2011). Herein, the anti-proliferative effect of PSO was investigated.…”

Section: Discussionmentioning

confidence: 99%

Psoralidin induces autophagy through ROS generation which inhibits the proliferation of human lung cancer A549 cells

Xue-nong

Zhao

et al. 2014

PeerJ

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Psoralidin (PSO), a natural furanocoumarin, is isolated from Psoralea corylifolia L. possessing anti-cancer properties. However, the mechanisms of its effects remain unclear. Herein, we investigated its anti-proliferative effect and potential approaches of action on human lung cancer A549 cells. Cell proliferation and death were measured by MTT and LDH assay respectively. Apoptosis was detected with Hoechst 33342 staining by fluorescence microscopy, Annexin V-FITC by flow cytometry and Western blot analysis for apoptosis-related proteins. The autophagy was evaluated using MDC staining, immunofluorescence assay and Western blot analyses for LC3-I and LC3-II. In addition, the reactive oxygen species (ROS) generation was measured by DCFH2-DA with flow cytometry. PSO dramatically decreased the cell viabilities in dose- and time-dependent manner. However, no significant change was observed between the control group and the PSO-treated groups in Hoechst 33342 and Annexin V-FITC staining. The expression of apoptosis-related proteins was not altered significantly either. While the MDC-fluorescence intensity and the expression ratio of LC3-II/LC3-I was remarkably increased after PSO treatment. Autophagy inhibitor 3-MA blocked the production of LC3-II and reduced the cytotoxicity in response to PSO. Furthermore, PSO increased intracellular ROS level which was correlated to the elevation of LC3-II. ROS scavenger N-acetyl cysteine pretreatment not only decreased the ROS level, reduced the expression of LC3-II but also reversed PSO induced cytotoxicity. PSO inhibited the proliferation of A549 cells through autophagy but not apoptosis, which was mediated by inducing ROS production.

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“…And psoralidin ( 58 ), a coumestan analogue, has been considered to have a novel biological activity as an agonist for both estrogen receptor alpha (ER α ) and ER β and activate the classical ER-signaling pathway in both ER-positive human breast and endometrial cell lines as well as non-human cultured cells transiently expressing ER α or ER β [45]. …”

Section: Pharmacological Activitiesmentioning

confidence: 99%

Phytochemical and Pharmacological Studies on the Genus Psoralea: A Mini Review

Wang

Zhang

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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The genus Psoralea, which belongs to the family Fabaceae, comprises ca. 130 species distributed all over the world, and some of the plants are used as folk medicine to treat various diseases. Psoralea corylifolia is a typical example, whose seeds have been widely used in many traditional Chinese medicine formulas for the treatment of various diseases such as leucoderma and other skin diseases, cardiovascular diseases, nephritis, osteoporosis, and cancer. So, the chemical and pharmacological studies on this genus were performed in the past decades. Here, we give a mini review on this genus about its phytochemical and pharmacological studies from 1910 to 2015.

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Psoralidin, a coumestan analogue, as a novel potent estrogen receptor signaling molecule isolated from Psoralea corylifolia

Cited by 53 publications

References 17 publications

Psoralea corylifolia L: Ethnobotanical, biological, and chemical aspects: A review

Psoralea corylifolia L: Ethnobotanical, biological, and chemical aspects: A review

Psoralidin induces autophagy through ROS generation which inhibits the proliferation of human lung cancer A549 cells

Phytochemical and Pharmacological Studies on the Genus Psoralea: A Mini Review

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