PSORI-CM02 ameliorates psoriasis in vivo and in vitro by inducing autophagy via inhibition of the PI3K/Akt/mTOR pathway

Lu, Yaxin; Wang, Ailin; Zhang, Jinwei; Leng, Li; Wei, Jianan; Li, Li; Chen, Haiming; Han, Ling; Lu, Chuanjian

doi:10.1016/j.phymed.2019.153054

Cited by 43 publications

(34 citation statements)

References 41 publications

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“…Other experimental formulas and phytotherapeutics PSORI-CM01 and PSORI-CM02. PSORI-CM01 is the basis of the second formula and it has been proven through animal studies to have antipsoriatic properties by inducing autophagy and inhibiting the cytokines and chemokines involved in psoriasis (34,45).…”

Section: Resultsmentioning

confidence: 99%

Influence of phytochemicals in induced psoriasis (Review)

Niculeț

Radaschin

Năstase³

et al. 2020

Exp Ther Med

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Section: Resultsmentioning

confidence: 99%

Influence of phytochemicals in induced psoriasis (Review)

Niculeț

Radaschin

Năstase³

et al. 2020

Exp Ther Med

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“…The PI3K/Akt-mTOR pathway is the most critical upstream signalling pathway associated with the regulation of autophagy. 41 In this pathway, when the cells are stimulated by the surrounding environment, the activated PI3K-I activates Akt with the help of phosphatidylinositol lipid-dependent protein kinase and inhibits the TSC1/2 complex to activate mTOR and inhibit autophagy. 42,43 The PI3K/Akt-mTOR pathway is associated with the occurrence of myocardial fibrosis and has a regulatory effect on the proliferation and migration of cardiac fibroblasts.…”

Section: Discussionmentioning

confidence: 99%

QiShenYiQi pill improves the reparative myocardial fibrosis by regulating autophagy

Yuan

Dong³

et al. 2020

J Cellular Molecular Medi

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Myocardial fibrosis is characterized by the metabolic imbalance of collagen synthesis and metabolism, which leads to pathological change of myocardial remodelling, and mostly seen in various cardiovascular diseases. 1 Myocardial fibrosis is categorized into reactive fibrosis and reparative fibrosis. 2 Reactive fibrosis occurs in the myocardial hypertrophy caused by excessive heart pressure without myocardial cell loss, whereas reparative fibrosis occurs in acute myocardial ischaemia and dilated cardiomyopathy. Both can affect the myocardial collagen content and promote myocardial diastolic and/or contractile dysfunction. Reparative myocardial fibrosis is the pathological basis for the development of myocarditis and post-inflammatory dilated cardiomyopathy to refractory heart failure, promoting the deterioration of the diseased heart function in dilated myocardium. 3 Therefore, reversing myocardial remodelling might add value to the treatment of dilated cardiomyopathy. 4 Dilated cardiomyopathy is complex heterogeneous cardiomyopathy characterized by ventricular enlargement and reduced myocardial contractile function, with a 5-year mortality rate of 15%-50%. 5 Among all the factors such as infection, autoimmunity, cellular immunity and genetics, autoimmune reactions

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“…Extracts of the herbs were prepared in distilled water and were concentrated and stored at 4°C for the study. Ultra-performance liquid chromatography was used to monitor batches of the PSORI-CM02 formula for quality control purposes, as described previously (17,19).…”

Section: The Preparation Of Psori-cm02mentioning

confidence: 99%

“…The formula has been used to treat psoriasis at the Guangdong Provincial Hospital of Chinese Medicine for decades. Our previous study found that PSORI-CM02 inhibits the proliferation of HaCaT cells and reduces the psoriasis area and severity index scores in mice with imiquimod (IMQ)induced psoriasis (17), regulates the T cell balance (17,18), inhibits the phosphorylation of components of the PI3K/Akt/ mTOR pathway to promote autophagy (19), inhibits the NF-kB signalling pathway and inflammatory factor secretion (17), and promotes M2-type macrophage polarisation (20).…”

Section: Introductionmentioning

confidence: 99%

Anti-Angiogenic Efficacy of PSORI-CM02 and the Associated Mechanism in Psoriasis In Vitro and In Vivo

Yang

Zhang

et al. 2021

Front. Immunol.

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Psoriasis is a chronic proliferative autoimmune dermatologic disease characterised by abnormal angiogenesis. Thus, regulating angiogenesis in the skin is an important treatment strategy for psoriasis. PSORI-CM02, an empirical Chinese medicine formula optimised from Yin Xie Ling, was created by the Chinese medicine specialist, Guo-Wei Xuan. Clinical studies have shown that PSORI-CM02 is safe and effective for the treatment of psoriasis. However, its anti-psoriatic mechanisms remain to be further explored. In this study, we investigated the effects of PSORI-CM02 on angiogenesis in the skin and the underlying mechanisms in IL-17A-stimulated human umbilical vein endothelial cells (HUVECs) and a murine model of imiquimod (IMQ)-induced psoriasis. In vitro, PSORI-CM02 significantly inhibited the proliferation and migration of IL-17A-stimulated HUVECs in a dose-dependent manner. Further, it markedly regulated the antioxidative/oxidative status and inflammation; suppressed the expression of VEGF, VEGFR1, VEGFR2, ANG1, and HIF-1α; and reduced the phosphorylation of MAPK signalling pathway components in IL-17A-stimulated HUVECs. In vivo studies showed that PSORI-CM02 markedly reduced angiogenesis in the skin of mice with IMQ-induced psoriasis, while significantly rebalancing antioxidant/oxidant levels; inhibiting the production of IL-6, TNF-α, IL-17A, and IL-17F; and repressing the synthesis of angiogenic mediators. In addition, PSORI-CM02 markedly reduced the activation of the MAPK signalling pathway in psoriatic skin tissue. Taken together, our results demonstrated that PSORI-CM02 inhibited psoriatic angiogenesis by reducing the oxidative status and inflammation, suppressing the expression of angiogenesis-related molecules, and inhibiting the activation of the MAPK signalling pathway in vitro and in vivo.

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PSORI-CM02 ameliorates psoriasis in vivo and in vitro by inducing autophagy via inhibition of the PI3K/Akt/mTOR pathway

Cited by 43 publications

References 41 publications

Influence of phytochemicals in induced psoriasis (Review)

Influence of phytochemicals in induced psoriasis (Review)

QiShenYiQi pill improves the reparative myocardial fibrosis by regulating autophagy

Anti-Angiogenic Efficacy of PSORI-CM02 and the Associated Mechanism in Psoriasis In Vitro and In Vivo

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