Psoriasiform Drug Eruption Induced by Anti-tuberculosis Medication: Potential Role of Plasma­cytoid Dendritic Cells

Role of dendritic cells in drug allergy

“…It has been hypothesized that plasmacytoid dendritic cells (pDCs) are specialized for viral recognition and antiviral responses and that activated pDCs are involved in psoriasiform and lichenoid drug reactions [8]. In addition to that, Sugita et al [43] have recently reported the role of skin pDCs in druginduced hypersensitivity syndrome (DIHS).…”

“…HDRs are often considered immune-mediated [3,4] and may affect the skin [5], inducing toxic epidermal necrolysis (TEN) as the most severe reaction, as well as the liver producing hepatotoxicity including liver failure [6,7]. In nonimmediate allergic reactions (NIRs) to drugs, mediated by specific immunological mechanisms, the skin is the most frequently involved target organ [8]. NIRs can appear hours, days, or even weeks after drug intake.…”

Isoniazid therapy for latent tuberculosis in psoriasis patients receiving biological agents: is it safe and efficacious?

“…The treatments recommended by clinical guidelines include isoniazid (isonicotinylhydrazine [INH]) 300 mg/day for nine months or rifampin therapy at 60 mg/day for four months. However, hepatotoxicity is a significant side effect of the administration of INH, and psoriasiform drug eruption has been described in patients taking anti‐tuberculosis medication …”

Uncomplicated Drug-Induced Disseminated Exanthemas

“…However, it may still be difficult to differentiate between a koebnerized drug exanthema and a drug-induced psoriasis. Also tuberculostatic medications have been implicated in psoriasiform exanthemas [29].…”