Psoriasis and Cardiovascular Disease

Shahwan, Kathryn T.; Kimball, Alexa B.

doi:10.1016/j.mcna.2015.08.001

Cited by 30 publications

(26 citation statements)

References 135 publications

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“…Henüz etiyolojisi tam olarak aydınlatılamamış olsa da psoriazis, birçok yazar tarafından artık sistemik enflamatuvar bir hastalık olarak kabul edilmektedir 2 . Özellikle son yıllarda psoriaziste artmış obezite, metabolik sendrom ve kardiyovasküler hastalık riski ile ilgili birçok çalışma yapılmıştır.…”

Section: Discussionunclassified

“…Özellikle son yıllarda psoriaziste artmış obezite, metabolik sendrom ve kardiyovasküler hastalık riski ile ilgili birçok çalışma yapılmıştır. Psoriazisdeki artmış enflamasyonun epitelyal disfonksiyona neden olduğu ve buna bağlı olarak kardiyovasküler hastalık riskinde artışa neden olduğu düşünülmektedir 2,[14][15][16] . Ürik asit hipertansiyon, metabolik sendrom ve aterosklerotik kalp hastalıkları gibi birçok durum ile ilişkili olduğu gösterilen metabolik bir belirteçtir [6][7][8] .…”

Section: Discussionunclassified

“…Çalışmamızda normal sınırlarda olsa bile metabolik sendrom bulunanlarda olmayanlara göre ürik asit düzeylerinin daha yüksek olduğu gösterilmiştir. Psoriazis ile aterosklerozun benzer patogenetik mekanizma ve enflamasyon yolağını paylaştığı gösterilmiştir 2,15 . Psoriazis hastalarında erken dönemde subklinik aterosklerozun varlığında müdahale edilmesi ileri dönemde gelişmesi muhtemel kardiyovasküler olayların engellenebilmesi açısından önemlidir.…”

Section: Abstract: Metabolic Syndrome Uric Acid Psoriasisunclassified

“…Ancak sadece deriye sınırlı olmayıp eklemleri de tutabilmektedir 1 . Hatta yeni çalışmalarda psoriaziste sistemik bir enflamasyonun geliştiği ve buna bağlı olarak psoriazisin metabolik sendrom ile kardiyovasküler hastalıklarla ilişkili olduğu gösterilmiştir [2][3][4][5] . Önemi son yıllarda daha iyi anlaşılmış metabolik bir marker olan ürik asitin metabolik sendrom, hipertansiyon ve kardiyovasküler hastalıklarla ilişkili olduğu düşünülmektedir [6][7][8][9] .…”

Section: Introductionunclassified

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The role of uric acid in metabolic syndrome in patients with psoriasis

Solak¹,

Dikicier²,

Erdem³

2017

TURKDERM

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Background and Design:Psoriasis patients have increased risk of obesity, metabolic syndrome and cardiovascular disease. Uric acid is a metabolic marker associated with metabolic syndrome and cardiovascular diseases. Uric acid levels increase in psoriasis as well. The aim of this study was to investigate the role of uric acid in metabolic syndrome in patients with psoriasis. Materials and Methods: Chronic plaque psoriasis patients who presented to the dermatology outpatient clinics in a university-affiliated training and research hospital and age-and gender-matched healthy individuals were included in the study. Waist circumference, height and weight measurements in both groups were recorded, and body mass index was calculated. Serum uric acid, urea, creatinine, C-reactive protein, fasting blood glucose, high-density lipoprotein cholesterol, total cholesterol, triglyceride and insulin levels were determined. Metabolic syndrome and insulin resistance status were evaluated. The findings were compared statistically. Results: Seventy patients with chronic plaque psoriasis (37 females, 33 males) and 60 healthy individuals (31 females, 29 males) were included in the study. The prevalence of metabolic syndrome and uric acid levels were found to be higher in the psoriasis group than in control group (p=0.003 and p=0.008, respectively). Serum uric acid levels and Psoriasis Area and Severity Index scores were higher in psoriasis patients with metabolic syndrome than in those without metabolic syndrome when psoriasis patients were evaluated separately (p=0.041, p=0.024, respectively). A positive correlation was observed between abdominal circumference and serum uric acid levels in psoriasis patients (p=0.003, r=0.350). AbstractAmaç: Enflamatuvar bir hastalık olan psoriaziste son yıllarda obezite, metabolik sendrom ve kardiyovasküler hastalık riskinin arttığı gösterilmiştir. Ürik asit metabolik sendrom ve kardiyovasküler hastalıklarla ilişkili ve aynı zamanda psoriaziste arttığı bilinen metabolik bir belirteçtir. Psoriazis hastalarındaki artmış metabolik sendrom riskinde ürik asitin rol oynayıp oynamadığını araştırmayı amaçladık. Gereç ve Yöntem: Üniversite afiliye eğitim ve araştırma hastanesi dermatoloji polikliniğinde görülmüş olan kronik plak psoriazisli hastalar ile yaş ve cinsiyet uyumlu sağlıklı kontrol grubu çalışmaya alındı. Hasta ve kontrol grubunun bel çevresi, boy ve kilo ölçümü kaydedildi. Vücut kitle indeksleri hesaplandı. Serum ürik asit, üre, kreatinin, C-reaktif protein açlık glukoz, yüksek yoğunluklu lipoprotein kolesterol, total kolesterol, trigliserid ve insülin değerleri ölçümleri kaydedildi. Hasta ve kontrol grubunda metabolik sendrom varlığı ve insülin direnci değerlendirildi. Sonuçlar istatistiksel olarak karşılaştırıldı. Bulgular: Kronik plak psoriazisli 70 hasta (37 kadın, 33 erkek) ile 60 sağlıklı kontrol (31 kadın, 29 erkek) çalışmaya alındı. Psoriazis hastalarında metabolik sendrom sıklığının kontrol grubuna göre daha sık ve ürik asit düzeyinin daha yüksek olduğunu saptadık (p=0,003, p=0,008, sır...

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Section: Discussionunclassified

Section: Abstract: Metabolic Syndrome Uric Acid Psoriasisunclassified

Section: Introductionunclassified

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The role of uric acid in metabolic syndrome in patients with psoriasis

Solak¹,

Dikicier²,

Erdem³

2017

TURKDERM

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“…[39][40][41] Among other inflammatory molecules, interleukins 2,6,7,8,12,15,17,18,20, and 23; tumor necrosis factor a; and interferon g participate in the expression of other chemokines and growth factors resulting in stimulation of inflammatory cells, endothelial dysfunction, and vascular smooth muscle proliferation that are all implicated in the pathophysiology of both psoriasis and atherosclerosis. 39,42,43 The common pathophysiological mechanisms of both diseases led research efforts to evaluate several markers of vascular damage and endothelial dysfunction in patients with psoriasis. [43][44][45] Comparisons between almost 2000 individuals with and without psoriasis showed increased common carotid intima-media thickness (cIMT) in patients with psoriasis compared to controls.…”

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confidence: 99%

Psoriasis and Cardiovascular Disease: Two Sides of the Same Coin?

2017

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Association Between Mediterranean Anti-inflammatory Dietary Profile and Severity of Psoriasis

et al. 2018

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IMPORTANCE Psoriasis is a chronic inflammatory disease. The Mediterranean diet has been shown to reduce chronic inflammation and has a positive effect on the risk of metabolic syndrome and cardiovascular events. Thus, we hypothesized a positive effect on the onset and/or severity of psoriasis. OBJECTIVE To assess the association between a score that reflects the adhesion to a Mediterranean diet (MEDI-LITE) and the onset and/or severity of psoriasis. DESIGN, SETTING, AND PARTICIPANTS The NutriNet-Santé program is an ongoing, observational, web-based questionnaire cohort study launched in France in May 2009. The present study was performed within the framework of the NutriNet-Santé program, with data collected and analyzed between April 2017 and June 2017. Patients with psoriasis were identified via a validated online self-completed questionnaire and then categorized by disease severity: severe psoriasis, nonsevere psoriasis, and psoriasis-free. Data on dietary intake (including alcohol) were gathered during the first 2 years of participation in the cohort to calculate the MEDI-LITE score (ranging from 0 for no adherence to 18 for maximum adherence). Potentially confounding variables (eg, age, sex, physical activity, body mass index, tobacco use, and a history of cardiovascular disease) were also recorded. Analyses used adjusted multinomial logistic regression to estimate the risk of having severe psoriasis or nonsevere psoriasis compared with being psoriasis-free. RESULTS Of the 158 361 total NutriNet-Santé participants, 35 735 (23%) replied to the psoriasis questionnaire. The mean (SD) age of the respondents was 47.5 (14.0) years; 27 220 (76%) of the respondents were women. Of these 35 735 respondents, 3557 (10%) individuals reported having psoriasis. The condition was severe in 878 cases (24.7%), and 299 (8.4%) incident cases were recorded (those arising more than 2 years after participant inclusion in the cohort). After adjustment for confounding factors, a significant inverse relationship was found between the MEDI-LITE score and having severe psoriasis: odds ratio (OR), 0.71; 95% CI, 0.55-0.92 for the MEDI-LITE score's second tertile (score of 8 to 9); and OR, 0.78; 95% CI, 0.59-1.01 for the third tertile (score of 10 to 18). CONCLUSIONS AND RELEVANCE Patients with severe psoriasis displayed low levels of adherence to the Mediterranean diet; this finding supports the hypothesis that the Mediterranean diet may slow the progression of psoriasis. If these findings are confirmed, adherence to a Mediterranean diet should be integrated into the routine management of moderate to severe psoriasis.

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Psoriasis and Cardiovascular Disease

Cited by 30 publications

References 135 publications

The role of uric acid in metabolic syndrome in patients with psoriasis

The role of uric acid in metabolic syndrome in patients with psoriasis

Psoriasis and Cardiovascular Disease: Two Sides of the Same Coin?

Association Between Mediterranean Anti-inflammatory Dietary Profile and Severity of Psoriasis

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