Psoriasis and HLA-Cw6

Tiilikainen, A; Lassus, A; Karvonen, Jaakko; Vartiainen, P.; Julin, Marja

doi:10.1111/j.1365-2133.1980.tb05690.x

Cited by 294 publications

(183 citation statements)

References 2 publications

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“…Evidence suggests that activation of T cells precedes epidermal proliferation (7) and that CD8+ T cells predominate in epidermal lesions (1)(2)(3). Moreover, the HLA association of this disease is consistent with psoriasis being a T-cellmediated autoimmune phenomenon, with the highest relative risk associated with HLA-Cw6 (8), although other HLA class I and class II antigens also have a positive association with the disease (9). To determine whether cells infiltrating psoriatic lesions exhibit restricted T-cell receptor gene use and oligoclonality, which would suggest a response to tissue antigens, we examined epidermal T cells isolated from shave biopsies from psoriatic lesions.…”

mentioning

confidence: 82%

CD8+ T cells in psoriatic lesions preferentially use T-cell receptor V beta 3 and/or V beta 13.1 genes.

Chang

Smith

Froning

et al. 1994

Proc. Natl. Acad. Sci. U.S.A.

231

138

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mentioning

confidence: 82%

CD8+ T cells in psoriatic lesions preferentially use T-cell receptor V beta 3 and/or V beta 13.1 genes.

Chang

Smith

Froning

et al. 1994

Proc. Natl. Acad. Sci. U.S.A.

231

138

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“…41 However, the exact location of PSORS1 gene remains controversial owing to extensive linkage disequilibrium across this region. Two genes lying within this interval have been intensively studied with respect to their role in psoriasis susceptibility.…”

Section: Psors1mentioning

confidence: 99%

Psoriasis: genetic associations and immune system changes

2006

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Psoriasis is a common inflammatory skin disease characterized by infiltration of inflammatory cells into the epidermis and altered keratinocyte differentiation. Psoriasis is currently thought of as a T-cell mediated 'Type-1' autoimmune disease. Gene expression changes in psoriasis lesions have been well documented, and strongly support an important role for tumor necrosis factor and interferon gamma signal pathways in its pathogenesis. The strongest genetic determinant of psoriasis identified to date lies within the class I region of the multiple histocompatibility locus antigen cluster, although its low penetrance implicates a requirement for other genetic risk factors. Multiple genome-wide linkage and an increasing number of association studies have been carried out, leading to multiple linkage peaks, and the identification of potential low risk variants. A number of these variants lie within genes encoding components of the immune system. However, the functional relationships between predisposing genetic variation is unclear, and presumably involves genetic susceptibility factors affecting both immune cell activation and keratinocyte differentiation. The interaction of environmental trigger factors with genetic effects is also not understood, but provide further evidence for the complex basis of this disease.

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“…14 The HLA region has been thoroughly examined in many studies, and associations with sub-classes of HLA such as B13, Bw57, Cw6 and DR7 have been reported. [19][20][21] We have found a strong correlation between the presence of Cw6 and early onset in this family material. 22 A number of studies have shown linkage to the HLA region, 13,16,[23][24][25] as does our patient material.…”

Section: Introductionmentioning

confidence: 92%

Psoriasis susceptibility locus in chromosome region 3q21 identified in patients from southwest Sweden

et al. 1999

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We have performed a pair-wise linkage study in the search for psoriasis susceptibility regions. A preliminary scan was performed on 20 families. In this set we obtained indications of linkage on chromosome 3q21. This region was further investigated using material from a total of 104 families (set 1B) resulting in a non-parametric linkage (NPL) of 1.77. The material was stratified in families whose parental origin is in southwest Sweden (set 1C). A maximum NPL value of 2.77 was obtained in this group. A transmission disequilibrium test (TDT) was performed on the stratified material (set 1C) and a significant P value of 0.005 was obtained, at marker D3S1269. The locus was confirmed with TDT in replicate material consisting of 148 families in which a single member was affected (P value 0.0007) at marker D3S1551. Thus, we have observed a significant P value using TDT in the vicinity of markers D3S1269/D3S1551, suggesting a novel psoriasis susceptibility region.

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Psoriasis and HLA-Cw6

Cited by 294 publications

References 2 publications

CD8+ T cells in psoriatic lesions preferentially use T-cell receptor V beta 3 and/or V beta 13.1 genes.

CD8+ T cells in psoriatic lesions preferentially use T-cell receptor V beta 3 and/or V beta 13.1 genes.

Psoriasis: genetic associations and immune system changes

Psoriasis susceptibility locus in chromosome region 3q21 identified in patients from southwest Sweden

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