"Psoriasis as a possible defect of the adenyl cyclase-cyclic AMP Cascade" by Voorhees and Duell, October 1971. Commentary: Cyclic adenosine monophosphate regulation of normal and psoriatic epidermis

Jj, Voorhees

doi:10.1001/archderm.118.10.862

Cited by 24 publications

(3 citation statements)

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“…Most of the debate stems from conflicting data regarding cAMP signaling in psoriatic keratinocytes. Whereas some laboratories have recorded elevation of adenylyl cyclase activity and cAMP levels in psoriasis, others report a decrease (Yoshikawa et al ., 1975; Wadskov et al ., 1979; Adachi et al ., 1980; Voorhees, 1982). In addition, other groups have found highly decreased binding of cAMP to PKA in erythrocytes membranes, which was specific for active psoriasis (Raynaud et al ., 1989; Schopf et al ., 2002).…”

Section: Discussionmentioning

confidence: 99%

“…Cellular differentiation and cell cycle are modulated by numerous signaling pathways, and hyperstimulation or dysregulation of these pathways represents key events leading to many diseases of epidermal hyperplasia. The cyclic adenosine monophosphate (cAMP)-signaling pathway is integral to both cellular differentiation and proliferation, and has been implicated in the pathogenesis of diseases of epidermal hyperplasia such as psoriasis (Yoshikawa et al ., 1975; Wadskov et al ., 1979; Adachi et al ., 1980; Voorhees, 1982; Grandjean-Laquerriere et al ., 2005). …”

Section: Introductionmentioning

confidence: 99%

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Soluble Adenylyl Cyclase Defines a Nuclear cAMP Microdomain in Keratinocyte Hyperproliferative Skin Diseases

Zippin

Chadwick

Levin

et al. 2010

Journal of Investigative Dermatology

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Cyclic adenosine monophosphate (cAMP) is a nearly ubiquitous signaling molecule important for numerous signaling pathways in human skin. We studied a novel class of mammalian adenylyl cyclase, the soluble adenylyl cyclase (sAC). We examined sAC localization in normal human skin and found it to be present in keratinocytes, melanocytes, mononuclear cells, eccrine ducts, and nerves. In normal skin, sAC keratinocyte staining was evenly distributed throughout the cell. However, in certain hyperproliferative disorders of the skin, including psoriasis, verruca vulgaris, and SCCIS on sun-damaged skin, sAC keratinocyte staining was predominantly nuclear. In contrast, in other hyperproliferative disorders, such as basal cell carcinoma, sAC staining was similar to normal human skin. Using a model of epithelial differentiation, we established that sAC migrates into the nucleus when differentiated cells are induced to reenter the cell cycle. Previous work had determined that nuclear sAC activates the cAMP-response-element-binding (CREB) transcription factor, and we found that in psoriasis lesions, nuclear sAC occurs concomitantly with activation of CREB. Hence, sAC may play a role in the pathogenesis of certain hyperproliferative skin disorders via modulation of gene expression.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Soluble Adenylyl Cyclase Defines a Nuclear cAMP Microdomain in Keratinocyte Hyperproliferative Skin Diseases

Zippin

Chadwick

Levin

et al. 2010

Journal of Investigative Dermatology

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“…Some authors have suggested that alcohol consumption may adversely affect psoriasis through multiple mechanisms, for example altering aspects of the immune response, predisposing drinkers to infections, which are well‐known triggers of psoriasis flares, enhancing mitogen‐driven lymphocyte proliferation, upregulating proinflammatory cytokines, influencing keratinocyte proliferation and differentiation, and barrier function. Table 1 summarizes the relevant data currently available on these aspects 24–48 …”

Section: Mechanisms Underlying the Interaction Between Alcohol And Ps...mentioning

confidence: 99%

Alcohol, psoriasis, liver disease, and anti‐psoriasis drugs

et al. 2011

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Over the last years, data have been accumulating regarding a possible association between alcohol and psoriasis. While it is still unclear whether alcohol misuse represents a true risk factor or merely an epiphenomenon of the cutaneous disease, a number of studies support the role of ethanol and its metabolites as triggering factors of psoriasis. A drinking habit also appears to exacerbate a preexisting psoriasis, and the magnitude of alcohol consumption may be related to both a higher incidence and severity of psoriasis. Evidence also shows that deaths from alcohol-related causes are significantly more frequent in patients with psoriasis than in normal controls. Alcohol consumption may adversely affect psoriasis through multiple mechanisms, such as increased susceptibility to infections, stimulation of lymphocyte and keratinocyte proliferation, and production of proinflammatory cytokines. Moreover, alcohol misuse can predispose to a greater risk of liver disease and potential drug interactions. Alcoholic and non-alcoholic liver diseases have both been found to be common in psoriatic patients. Tumor necrosis factor (TNF)-alpha, a key cytokine in psoriasis pathogenesis, has been found to have a crucial role in alcoholic hepatitis, and small preliminary studies have evaluated the effect of anti-TNF therapy in this condition. However, the use of anti-TNF-α drugs in alcoholic hepatitis is still controversial and needs to be further investigated. In this review, the relationship between alcohol and psoriasis will be reviewed and discussed, taking also into account recent findings related to liver disease and therapeutic implications.

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Lithium and Dermatological Disorders

Horrobin¹

1990

Lithium and Cell Physiology

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"Psoriasis as a possible defect of the adenyl cyclase-cyclic AMP Cascade" by Voorhees and Duell, October 1971. Commentary: Cyclic adenosine monophosphate regulation of normal and psoriatic epidermis

Cited by 24 publications

References 0 publications

Soluble Adenylyl Cyclase Defines a Nuclear cAMP Microdomain in Keratinocyte Hyperproliferative Skin Diseases

Soluble Adenylyl Cyclase Defines a Nuclear cAMP Microdomain in Keratinocyte Hyperproliferative Skin Diseases

Alcohol, psoriasis, liver disease, and anti‐psoriasis drugs

Lithium and Dermatological Disorders

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