Psoriasis Exacerbates the State of Insulin Resistance in Patients with Type 2 Diabetes

Su, Wen; Liu, Congying; Li, Yanyan; Pan, Junhong; Nguyen, Thiquynhnga; Zhou, Ligang

doi:10.2147/dmso.s312420

Cited by 5 publications

(3 citation statements)

References 38 publications

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“…HOMA, is a statistical method for assessing insulin resistance (HOMA-IR) and pancreatic -cell function (HOMA-β) of basal glucose and insulin or c-peptide [79,80]. The correlation between insulin and glucose in basal conditions reflect the balance between hepatic glucose output and secretion insulin that maintained by a feedback loop between the liver and -cells pancreas.…”

Section: Homa-ir and Homa-β Indexmentioning

confidence: 99%

Anti-Diabetic Effect of Okara Noodles on Streptozotocin-Nicotinamide Induced Diabetic Rats

Lesa,

Ahmad,

Mayangsari

et al. 2024

Trends Sci

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Okara is a by-product of soybean curd residue resulting from the processing of soy milk and tofu. Okara noodles were made from wheat flour (WF) and okara flour (OF) with a few modifications that consist of high dietary fiber. Therefore, okara can be considered as an effective functional component with health-promoting benefits, especially for diabetes mellitus. Albeit, the anti-diabetic effect has not been conscientiously investigated. The goal of the current research was to evaluate the anti-diabetic effect of okara noodles on Streptozotocin-Nicotinamide induced diabetes mellitus rats. In the experiment, the different ratios of OF was used to prepared 3 formulated noodles (F0, F1 and F2) where F0 (0 % OF; 100 % WF), F1 (25 % OF; 75 % WF) and F2 (45 % OF; 55 % WF). Twenty-four male wistar rats were randomly divided into 4 groups (6 rats/groups), normal group of rats fed with standard feed and 3 diabetics groups, respectively fed with standard feed and formulated noodles variety (F0, F1 and F2). In in vivo analysis, it indicated, diabetes mellitus rats fed okara noodles had lower blood glucose levels and HOMA-IR and higher serum insulin levels and HOMA-b index than those fed control noodles (F0) as well as body weight managing activity. These outcomes demonstrated okara noodles possess significant anti-diabetic activity, prompting the applicability of okara noodles as potential food for the diabetes mellitus food products. HIGHLIGHTS Diabetes mellitus (DM) rats fed okara noodles had lower BGLs and HOMA-IR DM rats fed okara noodles had higher serum insulin levels and HOMA-b index than those fed control noodles as well as body weight managing activity Okara can be considered as an effective functional component for the anti-diabetic effect on STZ-NA induced DM rats GRAPHICAL ABSTRACT

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Section: Homa-ir and Homa-β Indexmentioning

confidence: 99%

Anti-Diabetic Effect of Okara Noodles on Streptozotocin-Nicotinamide Induced Diabetic Rats

Lesa,

Ahmad,

Mayangsari

et al. 2024

Trends Sci

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“…6 Therefore, the original mini-CEX is frequently modified for use in specialized training fields. [7][8][9] Type 2 diabetes (T2D) is a prevalent metabolic disease that causes many complications in multiple organs and systems, 10,11 necessitating the completion of numerous questionnaires for medical history and physical examination. 12 It is also a disease that is commonly used in the Department of Endocrinology to assess the efficacy of training in medical students and clinicians.…”

Section: Introductionmentioning

confidence: 99%

A Pilot Study of Modified Mini-Clinical Evaluation Exercises (Mini-CEX) in Rotation Students in the Department of Endocrinology

He¹,

Su²,

Zhou³

et al. 2022

DMSO

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Background The mini-clinical evaluation exercise (mini-CEX) is an excellent tool for assessing the clinical abilities of medical students in intense clinical practice. In this study, the Mini-CEX was adapted to professional questionnaires for Diabetes Mellitus (DM), and examined in medical students completing their clerkship rotation in the department of endocrinology. Methods From January 2021 to January 2022, all rotating medical students at Shanghai Pudong Hospital completed two mini-CEX exams before and following their rotation under the supervision and guidance of six tutors. The mini-CEX form was modified in this study primarily for inpatient management based on our clinical experience and updated DM guidelines of the American Diabetes Association (ADA), the European Association for the Study of Diabetes (EASD), and the Chinese Diabetes Society (CDS). Each component of the mini-CEX assessment, including medical interviews, physical examination, clinical judgment, clinical management, and overall clinical competence was evaluated using a nine-item questionnaire. Results Our findings revealed that the second-round performance on the assessments significantly improved, as indicated by higher scores on each component. The Pearson association analysis revealed that the feedback time of the first examination was markedly associated with improved overall scores (r= 0.391, p<0.001). However, no correlations were discovered between patient age, gender, disease severity disparity, or the interval between examinations (p>0.05). Additional regression analysis revealed that the feedback time during the initial examination was the most significant contributor to the increased overall scores (β=0.391, p<0.001). Conclusion This newly designed mini-CEX form based on current ADA and EASD guidelines may assist trainees in more effectively diagnosing and managing DM in inpatients, particularly those with macrovascular, microvascular, or peripheral nerve neuropathy. This study aims to assess the efficacy of administering a modified mini-CEX form to rotating trainees participating in an endocrine clerkship.

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“…Psoriatic patients with type 2 diabetes (T2D) had a significantly higher IR than T2D patients without psoriasis. However, psoriatic patients with T1D may have relatively preserved pancreatic β cell function due to their significantly higher levels of C-peptide in both the fasted state and after the glucose challenge [ 6 ]. Epidemiological studies report that psoriasis is associated with increased incidence rates of new-onset DM, and the severity of psoriasis is correlated with the risk of T2D [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

B7-H4 Polymorphism Influences the Prevalence of Diabetes Mellitus and Pro-Atherogenic Dyslipidemia in Patients with Psoriasis

Yang

Huang

Han

et al. 2022

JCM

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Background: The co-inhibitory molecule B7-H4 is located in the genomic regions associated with type 1 diabetes (T1D) susceptibility. However, the correlation of B7-H4 with glycometabolism and dyslipidemia has never been studied. Objective: To explore the influence of B7-H4 polymorphism on the prevalence of diabetes mellitus (DM) and dyslipidemia in psoriasis. Methods: In this single-center cross-sectional study, we recruited 265 psoriatic patients receiving methotrexate (MTX) treatment. Thirteen single-nucleotide polymorphisms (SNPs) in B7-H4 were genotyped. Serum levels of total cholesterol (TC), triglycerides (TG), lipoprotein (a) (LP(a)), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein (LDL), apolipoprotein A1 (ApoA1), and apolipoprotein B (ApoB) were measured at baseline and week 12. Results: The GG genotype carriers of rs12025144 in B7-H4 had a higher prevalence of DM (57.14% vs. 17.71% vs. 18.67%, p = 0.0018), and had a poorer response to MTX in diabetic patients (p < 0.05), compared with AA or AG genotype carriers. The AG genotype of rs2066398 was associated with higher levels of pro-atherogenic lipids. MTX significantly downregulated the level of anti-atherogenic lipid ApoA1 in AA genotype carriers of rs2066398. Conclusions: The genotypes rs12025144 and rs2066398 in B7-H4 were correlated with a higher prevalence of DM and dyslipidemia in psoriasis, respectively.

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Psoriasis Exacerbates the State of Insulin Resistance in Patients with Type 2 Diabetes

Cited by 5 publications

References 38 publications

Anti-Diabetic Effect of Okara Noodles on Streptozotocin-Nicotinamide Induced Diabetic Rats

Anti-Diabetic Effect of Okara Noodles on Streptozotocin-Nicotinamide Induced Diabetic Rats

A Pilot Study of Modified Mini-Clinical Evaluation Exercises (Mini-CEX) in Rotation Students in the Department of Endocrinology

B7-H4 Polymorphism Influences the Prevalence of Diabetes Mellitus and Pro-Atherogenic Dyslipidemia in Patients with Psoriasis

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