Psoriasis flare following ChAdOx1-S/nCoV-19 vaccination in patients with psoriasis under biologic treatment

Tsai, Tsen‐Fang; Chao, Jen-Ping

doi:10.4103/ds.ds_45_21

Cited by 11 publications

(4 citation statements)

References 7 publications

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“…However, the association between vaccination and the worsening of psoriasis has been reported mainly after vaccines against influenza (H1N1), pneumococcal pneumonia, and yellow fever [6]. Recently, this association has been suggested with COVID-19 vaccines [11][12][13][14].…”

Section: Discussionmentioning

confidence: 99%

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Psoriasis worsening related to COVID-19 vaccination: Report from a single-center

Boubnane¹,

Faras²,

Aboudourib³

2023

Our Dermatol Online

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Background: Recently, reports have described cases of the onset or exacerbation of psoriasis related to COVID-19 vaccination. In this study, we sought to describe the clinical features and evolutionary aspects of psoriasis exacerbation after COVID-19 vaccination. Materials and Methods: This was a prospective and descriptive study conducted over a period of eighteen months at the Department of Dermatology and Venereology of the Mohammed VI University Hospital in Marrakech. We included all patients followed for psoriasis who received at least one dose of Sinopharm, AstraZeneca, or Pfizer COVID-19 vaccine. Results: A total of 148 patients were included in the study, among which 69 received a Sinopharm vaccine, 48 received an AstraZeneca vaccine, and 31 received a Pfizer vaccine. The mean age was 49 years. There were 82 males and 66 females, giving a sex ratio of 1.6. The comorbidities included hypertension in 27.7% of the cases, diabetes in 14.8%, dyslipidemia in 10.8%, and thyroiditis in 2%. Eight exacerbations of psoriasis after COVID-19 vaccination were noted. The mean duration of lesion development was 11.5 days. The vaccines involved were Sinopharm in 5 patients and AstraZeneca in 3 patients. The median PASI before vaccination was 7.8 and the median PASI after vaccination was 20.5. Three patients presented with severe erythematous lesions requiring hospitalization and the introduction of systemic therapy. Extension of the lesions to localized psoriasis was noted in five patients. Conclusion: COVID-19 vaccination may be a trigger for psoriasis, as suggested by multiple studies. However, these events should in no way contraindicate vaccination in patients with psoriasis. Key words: vaccination; COVID-19; psoriasis; exacerbation

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Section: Discussionmentioning

confidence: 99%

“…Recently, there have been reports describing cases of the onset or exacerbation of psoriasis related to COVID-19 vaccination [11][12][13]. The aim of our study was to describe the clinical features and evolutionary aspects of the aggravation of psoriasis after COVID-19 vaccination.…”

Section: Introductionmentioning

confidence: 99%

Psoriasis worsening related to COVID-19 vaccination: Report from a single-center

Boubnane¹,

Faras²,

Aboudourib³

2023

Our Dermatol Online

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“…Guidelines have been established to determine the optimal timing of vaccination for individuals on immunomodulatory drugs to ensure a proper vaccine response [16]. Despite this, there have been reports of new or worsening psoriasis with an increase in the number of vaccinations received [17].According to recent studies, COVID-19 vaccination may trigger psoriasis, especially when there are no other underlying factors. The short interval between vaccination and psoriasis onset indicates a potential correlation.…”

Section: Can Drive New or Exacerbated Psoriasis After Covid-19 Vaccin...mentioning

confidence: 99%

Potential Mechanisms Driving the Development of Psoriasis after COVID-19 Vaccine

2023

medbm

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This paper conducts a systematic review of the pathogenesis of psoriasis with the COVID-19 vaccine, using skin inflammation as a key point and delayed inflammatory response and cytokines as potential mechanisms driving psoriasis after COVID-19 vaccination. Reports from the global Centers for Disease Control (CDC) Vaccine Adverse Event Reporting System (VAERS) data reveal that psoriasis can be newly developed or exacerbated following vaccination against novel coronavirus pneumonia (COVID-19) despite global vaccination.

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“…In different studies, the incidence of PsA among patients with psoriasis ranged from 0.27 to 2.7 per 100 person-years [ 1 ]. Multiple inducing or aggravating factors for psoriasis have been reported, including drugs, infection, stress, hormonal changes, and more recently, COVID-19 infection and its vaccination [ 2 ]. PsA has been associated with the severity of psoriasis, physical traumas, obesity, and smoking [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Drug- or Vaccine-Induced/Aggravated Psoriatic Arthritis: A Systematic Review

Yeh,

Tsai

2024

Dermatol Ther (Heidelb)

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Introduction Drugs and vaccines have been less studied as inducing or aggravating factors for psoriatic arthritis (PsA) compared with psoriasis. Thus, the present study collected and summarized the publications to date about this issue. Methods We conducted a systematic literature search through the PubMed, Embase, and Cochrane databases to identify all reports on potential drug- and vaccine-related PsA events until 28 February 2023. Results In total, 179 cases from 79 studies were eligible for study. Drugs commonly reported include coronavirus disease 2019 (COVID-19) mRNA vaccines (6 cases), bacillus Calmette–Guerin (BCG) vaccine (3 cases), interferon (18 cases), immune-checkpoint inhibitors (ICI) (19 cases), and biologic disease-modifying antirheumatic drugs (bDMARDs) (127 cases). Drugs causing psoriasis may also induce or aggravate PsA (6 cases). BDMARD-related PsA mostly occurred in a “paradoxical” setting, in which the bDMARDs approved for the treatment of psoriasis induce or aggravate PsA. The reported latency may be delayed up to 2 years. Peripheral arthritis (82.3%) was the most common manifestation of drug- and vaccine-related PsA, followed by dactylitis (29.1%), enthesitis (23.4%), and spondyloarthritis (17.7%). Conclusions Drugs and vaccines may be implicated in the aggravation of PsA. Possible mechanisms include cytokine imbalance, immune dysregulation, or inadequate PsA treatment response compared with psoriasis. Most reports are case based without controls, so more studies are needed to further prove the causality. However, early recognition of factors causing or aggravating PsA is important to prevent the irreversible joint damage. Supplementary Information The online version contains supplementary material available at 10.1007/s13555-023-01082-z.

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Psoriasis flare following ChAdOx1-S/nCoV-19 vaccination in patients with psoriasis under biologic treatment

Cited by 11 publications

References 7 publications

Psoriasis worsening related to COVID-19 vaccination: Report from a single-center

Psoriasis worsening related to COVID-19 vaccination: Report from a single-center

Potential Mechanisms Driving the Development of Psoriasis after COVID-19 Vaccine

Drug- or Vaccine-Induced/Aggravated Psoriatic Arthritis: A Systematic Review

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