Psoriasis in elderly patients in the Côte d'Ivoire: socio‐demographic, clinical, and therapeutic aspects, and follow‐up

Kassi, K.; Djeha, D.; Gbery, I.P.; Kouamé, K.; Sangaré, A.

doi:10.1111/ijd.13138

Cited by 11 publications

(5 citation statements)

References 16 publications

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“…Although the absolute number and incidence of events were high above 65 years and low under 65, individuals who develop psoriasis at younger ages (40-60 years) are more likely to develop AD than age-matched individuals who are not diagnosed with psoriasis. In this regard, previous studies have shown that aging promotes a decrease in T cell immune function thereby reducing inflammation and leads to suppress the development of skin inflammatory diseases, which may support our hypothesis [30][31][32] . Additionally, since elderly people have various chronic diseases such as diabetes mellitus, hypertension, hyperlipidemia and depression and take many kinds of drugs, the effect of psoriasis on the development of AD may be more sensitive in middle age than in older age 33,34 .…”

Section: Discussionsupporting

confidence: 88%

Increased risk of Alzheimer’s disease in patients with psoriasis: a nationwide population-based cohort study

Kim

Park

Lee

et al. 2020

Sci Rep

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Although the pathogenesis of Alzheimer's disease (AD) is unclear, neuroinflammation appears to play a role in its development. Psoriasis is a chronic inflammatory skin disease that has recently been found to genetically overlap with AD. We aimed to investigate the risk of AD in patients with psoriasis. Subjects with psoriasis (n = 535,927) and age-and sex-matched controls without psoriasis (at a 5:1 ratio; n = 2,679,635) who underwent ≥3 health examinations between 2008 and 2014 were included, drawn from the Korean National Health Insurance System database. There were 50,209 cases of AD (1.87%) in controls without psoriasis and 11,311 cases (2.11%) in patients with psoriasis, and the median follow-up was 3.35 years. In a multivariable-adjusted model, patients with psoriasis showed a significantly increased risk of AD (hazard ratio, 1.09; 95% CI, 1.07-1.12, p < 0.0001) compared to controls without psoriasis. Among patients with psoriasis, the risk of AD was significantly increased in psoriasis patients not receiving systemic therapy compared to those receiving systemic therapy (hazard ratio, 1.10; 95% CI, 1.08-1.12 vs. hazard ratio, 0.99; 95% CI: 0.90-1.09, p < 0.0001). The incidence of AD was significantly increased in patients with psoriasis compared to control subjects without psoriasis. Of note, systemic treatment for psoriasis was associated with a reduced risk of AD.

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Section: Discussionsupporting

confidence: 88%

Increased risk of Alzheimer’s disease in patients with psoriasis: a nationwide population-based cohort study

Kim

Park

Lee

et al. 2020

Sci Rep

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“…All of our patients were diagnosed as having plaque-type psoriasis, consistent with previous studies reporting the plaque-type to be the most common type of psoriasis. 4,5,[9][10][11][12][13][14][15] The number of patients with other psoriasis types was too small for us to draw any conclusion. Nonetheless, a study in France observed a higher frequency of guttate and inverse psoriasis among patients aged > 70 years, 5) whereas a study in Côte d'Ivoire demonstrated an increasing tendency for pustular and inverse psoriasis among patients with elderly-onset psoriasis.…”

Section: Discussionmentioning

confidence: 90%

“…Nonetheless, a study in France observed a higher frequency of guttate and inverse psoriasis among patients aged > 70 years, 5) whereas a study in Côte d'Ivoire demonstrated an increasing tendency for pustular and inverse psoriasis among patients with elderly-onset psoriasis. 11) Compared with early onset psoriasis, late-onset psoriasis generally has a milder disease severity. 5,9) However, as we only included patients who received phototherapy, which is the treatment of choice for moderate-to-severe psoriasis, none of our patients had mild disease severity at baseline.…”

Section: Discussionmentioning

confidence: 99%

“…5,6,8,9) Although the demographic and clinical characteristics of patients with psoriasis have been evaluated in many countries, studies specifically on geriatric patients remain scarce and none have focused on patients receiving phototherapy, who generally have moderate-to-severe psoriasis. 4,5,[9][10][11][12][13][14][15] Obtaining this information may provide a better understanding of the psoriasis characteristics in this population and help clinicians make appropriate decisions. Phototherapy is a good alternative to systemic therapy, especially for older patients with polypharmacy, and has long been utilized with great efficacy and safety for many dermatoses.…”

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confidence: 99%

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Sociodemographic and Clinical Characteristics of Geriatric Patients with Psoriasis Receiving Narrowband Ultraviolet B Phototherapy

Legiawati

Astriningrum

Yusharyahya

et al. 2020

Ann Geriatr Med Res

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“…The literature search returned a total of 145 publications and 10 of these described patients in Africa or the Middle East. Of these 10 publications, there were 4 research articles (Table 1), [20][21][22][23] 3 reviews (Table 2) Table 3), 26,27 and 1 case study (published in Hebrew). 28 Two of the 4 research articles described non-interventional studies and 2 reported data from studies on the safety and efficacy of phototherapy (1 in patients with plaque psoriasis localized to the scalp or palmoplantar areas and 1 in patients ≥65 years of age).…”

Section: Resultsmentioning

confidence: 99%

<p>The Unmet Need for Clinical Guidelines on the Management of Patients with Plaque Psoriasis in Africa and the Middle East</p>

Steinhoff¹,

Ammoury²,

Ahmed³

et al. 2020

PTT

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Purpose: Dermatologists practicing in African and Middle Eastern countries face numerous challenges when managing patients with plaque psoriasis, especially those with disease in a difficult-to-treat anatomic area or those who are a pediatric, geriatric, or pregnant patient. The publication of comprehensive, up-to-date, region-specific clinical guidelines may help to address some of these challenges and improve outcomes. We conducted a literature review to identify recent guidelines and other publications describing patients with plaque psoriasis in Africa and the Middle East. Patients and Methods: An online literature search of the PubMed database was conducted to identify publications reporting clinical guidelines and research studies on plaque psoriasis. The search included all articles published from January 2008 to March 2020 inclusive. The titles and abstracts of all search results were screened by a reader to identify those that described patients in Africa or the Middle East. Results: A total of 145 publications were identified by the literature search and screened by a reader. There were 10 publications that described patients in Africa or the Middle East: 4 research articles, 3 reviews, 2 guidelines, and 1 case study. The 2010 guidelines from South Africa made recommendations for treating plaque psoriasis of varying severity, although without specific recommendations for difficult-to-treat anatomic areas or pediatric, geriatric, or pregnant patients. The 2014 guideline on biologics from Saudi Arabia included recommendations for the use of these agents in patients with plaque psoriasis, including difficult-to-treat anatomic areas and pediatric patients (TNF inhibitors only), but provided no recommendations for pregnant or geriatric patients. Conclusion: There is an urgent unmet need for comprehensive clinical guidelines on the management of patients with plaque psoriasis in Africa and the Middle East. Region-specific studies on the epidemiology, burden of disease, and the safety and effectiveness of newer pharmacotherapies are needed to support the development of such guidelines.

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Psoriasis in elderly patients in the Côte d'Ivoire: socio‐demographic, clinical, and therapeutic aspects, and follow‐up

Abstract: Topical agents could be the first-line treatment in geriatric patients in poor countries. If necessary, systemic agents should be used by taking into account the severity of psoriasis, presence of comorbidity factors, immune system level, and lifestyle.

Cited by 11 publications

References 16 publications

Increased risk of Alzheimer’s disease in patients with psoriasis: a nationwide population-based cohort study

Increased risk of Alzheimer’s disease in patients with psoriasis: a nationwide population-based cohort study

Sociodemographic and Clinical Characteristics of Geriatric Patients with Psoriasis Receiving Narrowband Ultraviolet B Phototherapy

<p>The Unmet Need for Clinical Guidelines on the Management of Patients with Plaque Psoriasis in Africa and the Middle East</p>

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