Psoriasis is associated with lipid abnormalities at the onset of skin disease

Mallbris, Lotus; Granath, Fredrik; Hamsten, Anders; Ståhle, Mona

doi:10.1016/j.jaad.2005.11.1079

Cited by 306 publications

(351 citation statements)

References 33 publications

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“…The available study results are, again, inconsistent. Many authors have shown elevated concentrations of apolipoproteins (apo A1, apo B, apo C and apo E) in the serum of patients with psoriasis [35][36][37]. Some studies have found no change relative to the control group [38,39], and others have shown a decrease in apolipoprotein levels [34].…”

Section: Lipidy W Surowicy Cholesterole Trójglicerydy I Apolipoproteinymentioning

confidence: 99%

“…Wyniki badań są rów-nież niespójne. Wielu autorów wykazało zwiększo-ne stężenie apolipoprotein (apo A1, apo B, apo C i apo E) w surowicy chorych na łuszczycę [35][36][37]. Niektórzy nie obserwowali zmian w porównaniu z grupą kontrolną [38,39], inni stwierdzili zmniejszenie ich stężenia [34].…”

Section: Lipidy W Surowicy Cholesterole Trójglicerydy I Apolipoproteinyunclassified

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The role of lipids in psoriasis

Baran¹,

Kiluk²,

Myśliwiec³

et al. 2017

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Psoriasis, affecting 2-4% of the world's population, is a chronic recurrent inflammatory skin disease. Its multifactorial aetiopathogenesis consists of, for example, abnormal epidermal proliferation, immune disturbances, and genetic, psychosomatic, environmental and hormonal factors. Psoriasis is also considered to be a systemic disorder closely associated with cardiovascular diseases, atherosclerosis, diabetes mellitus, obesity or metabolic syndrome. Lipids have a variety of biological functions. They participate not only in energy storage and expenditure or the formation of cell membranes, but also in inflammatory and metabolic signalling pathways. Disturbances in their homeostasis lead to the development of immunometabolic disorders, including psoriasis. Based on the available literature, this article presents selected molecular and clinical aspects involved in the multidirectional effect of lipids on psoriasis.streszczenie Łuszczyca, która występuje u 2-4% populacji na świecie, jest przewlekłą i nawrotową chorobą zapalną skóry. Na jej wieloczynnikową etiopatogenezę składają się m.in. nieprawidłowa proliferacja naskórka, zaburzenia immunologiczne, czynniki genetyczne, psychosomatyczne, środowiskowe i hormonalne. Łuszczyca jest również uznawana za schorzenie ogólnoustrojowe, związane z chorobami układu sercowo--naczyniowego, miażdżycą, cukrzycą, otyłością i zespołem metabolicznym. Lipidy pełnią wiele biologicznych funkcji, biorą udział nie tylko w magazynowaniu i wydatkowaniu energii, tworzeniu błon komórko-wych, lecz także w zapalnych i metabolicznych szlakach sygnałowych. Zaburzenia ich homeostazy powodują rozwój schorzeń immunometabolicznych, w tym łuszczycy. W niniejszej pracy przedstawiono na podstawie dostępnego piśmiennictwa wybrane aspekty molekularne i kliniczne wielokierunkowego wpływu lipidów na łuszczycę.

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Section: Lipidy W Surowicy Cholesterole Trójglicerydy I Apolipoproteinymentioning

confidence: 99%

Section: Lipidy W Surowicy Cholesterole Trójglicerydy I Apolipoproteinyunclassified

The role of lipids in psoriasis

Baran¹,

Kiluk²,

Myśliwiec³

et al. 2017

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“…Psoriasis patients have been identified as having a higher frequency of hyperlipidemia, depression, hypertension, insulin resistance and diabetes mellitus, and homocysteinemia. 13,[16][17][18][19][20][21][22] Behavioral risk factors, including obesity and smoking, will be discussed in the following section.…”

Section: General Cardiovascular Riskmentioning

confidence: 99%

National Psoriasis Foundation clinical consensus on psoriasis comorbidities and recommendations for screening

Kimball

Gladman

Gelfand

et al. 2008

Journal of the American Academy of Dermatology

381

321

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“…Psoriasis is associated with increased risk of cardiovascular abnormalities, hypertension, dyslipidemia, atherosclerosis, diabetes mellitus (type 2), obesity, chronic obstructive pulmonary disease (COPD), cerebral stroke, osteoporosis, cancer and depression. The previous literature also suggests that lipid metabolism disorders may play a role in pathogenesis of psoriasis [9]. Therefore, it is important to evaluate various factors responsible for pathogenesis of these co morbidities and co mortalities.…”

Section: Introductionmentioning

confidence: 99%

Study of Lipid profile and Paraoxonase-1 Activity in Psoriatic patients

Arora¹,

Kumar²,

Mahat³

et al. 2015

Int J of Biomed & Adv Res

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Background: Psoriasis is a common recurrent disease of skin characterised by excessive cell proliferation and incomplete differentiation in lesional epidermis. Aim: The present study was aimed to determine lipid parameters and paraoxonase activity in psoriatic patients. Methods: The study included 100 subjects of age group 30-60 years, out of which 50 were patients of psoriasis (Case group) and rest 50 were normal healthy individuals of same age group (Control group). Result: Our study showed significant increase (p<0.001) in the levels of Cholesterol, Triglyceride, LDL and VLDL in patients of psoriasis as compared to control group. Also, we found significant decreased levels of serum HDL and PON-1 in psoriatic patients as compared to control group. Conclusion: Our study concludes that altered lipid profile and paraoxonase may be responsible for the higher prevalence of systemic complication such as metabolic and cardiovascular diseases.

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Psoriasis is associated with lipid abnormalities at the onset of skin disease

Cited by 306 publications

References 33 publications

The role of lipids in psoriasis

The role of lipids in psoriasis

National Psoriasis Foundation clinical consensus on psoriasis comorbidities and recommendations for screening

Study of Lipid profile and Paraoxonase-1 Activity in Psoriatic patients

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