Psoriasis, psoriatic arthritis and risk of gout in US men and women

Abstract

Objective Individuals with psoriasis have been found to have increased blood levels of uric acid. However, there is no prospective data on the association between psoriasis and uric acid levels and subsequent development of gout. In this study, we examined the risk of gout among individuals with psoriasis and psoriatic arthritis (PsA) in two cohorts of men and women, the Health Professionals Follow-up Study (HPFS) (1986-2010) and Nurses' Health Study (NHS) (1998-2010). Methods A total of 27,751 men and 71,059 women were included in the analysis. Lifetime history of physician-diagnosed incident psoriasis and PsA was confirmed by validated supplementary questionnaires. Incident gout diagnoses were confirmed based on the American College of Rheumatology survey criteria. We used Cox proportional hazards models controlling for potential risk factors to calculate the hazard ratios (HRs) with 95% confidence intervals (CIs) of incident gout while simultaneously adjusting for several common risk factors. Results We documented 2,217 incident cases of gout during the follow-up. Psoriasis was associated with an increased risk of subsequent gout with a multivariate HR of 1.71 [95% confidence interval (CI), 1.36-2.15] in the pooled analysis. Risk of gout was substantially augmented among those with psoriasis and concomitant PsA [pooled multivariate HR: 4.95, (95% CI, 2.72 to 9.01)] when compared to participants without psoriasis. Conclusions In this prospective study of US women and men, psoriasis and PsA were associated with an increased risk of gout.

Gout and Association with Erectile Dysfunction

“…Further, recent reports have recognized yet additional comorbidities associated with gout, including obstructive sleep apnea and psoriasis 9,10 . One by-product of the cumulative nature of these gout-comorbidity reports is to prompt consideration of the directionality of the association.…”

Concurrent psoriasis and gout

“…There are case reports in the literature describing the simultaneous occurrence of psoriasis and gout [1,[5][6][7]. These reports have revealed that the risk of gout is increased with psoriasis, particularly among patients with PsA [4]. However, there are conflicting reports regarding this finding.…”

“…Several reports have described the association of psoriasis with metabolic derangements such as metabolic syndrome and hyperuricemia [2,3]. Psoriatic arthritis ((PsA) is an inflammatory seronegative arthritis which can occur in up to one-fourth of patients with psoriasis [4]. There are case reports in the literature describing the simultaneous occurrence of psoriasis and gout [1,[5][6][7].…”

Psoriasis epidemiology issues

“…Алкоголизм, ожирение, курение [7][8][9] повышают риск развития псориаза. Различные по-ражения сердечно-сосудистой, эндокринной систе-мы, заболевания печени и желчевыводящих путей, желудочно-кишечного тракта относятся к числу ча-стых сопутствующих заболеваний [10][11][12][13][14][15][16][17][18][19][20]. При псориазе отмечен повышенный риск возникнове-ния некоторых злокачественных новообразований [21].…”

“…У пациентов с псориазом доказан высокий риск сахарного диабета, подагры, воспалительных забо-леваний желудочно-кишечного тракта и желчевы-водящих путей, болезни Крона [16][17][18][19][20].…”