Psoriasis therapy by Chinese medicine and modern agents

Abstract

Psoriasis is a chronic, painful, disfiguring and non-contagious skin disease that has globally affected at least 200 million patients. In general, mild to moderate psoriasis patients will be treated by chemical drugs or Chinese medicine, while targeting systemic biological drugs have been successfully developed with good efficacy but high cost burden to patients with severe psoriasis. Since the underlying mechanisms of psoriasis are not well understood, in this review, psoriasis pathogenesis and clinical therapeutic principles by modern medicine and Chinese medicine are extensively described. Based on the data from the China Food and Drug Administration, the majority of chemical drugs are utilized as the topical formulations, while Chinese medicines are mainly delivered by an oral route, suggesting that the market for topical preparations of Chinese medicine to treat psoriasis is worth to exploration. Moreover, considering the unique clinical therapeutic theory and successful clinical application of Chinese medicine in the treatment of psoriasis, we believe that development of new small molecule drugs based on Chinese medicine will be a promising strategy to reduce therapeutic costs and improve safety for psoriatic patients.

Gold lotion from citrus peel extract ameliorates imiquimod‐induced psoriasis‐like dermatitis in murine

“…In addition, the cost of biologics is high. It would therefore be desirable to use botanical products as alternative psoriasis treatments that are inexpensive and have fewer side effects . A large number of botanicals have been studied for the treatment of psoriasis .…”

“…It would therefore be desirable to use botanical products as alternative psoriasis treatments that are inexpensive and have fewer side effects. 36 A large number of botanicals have been studied for the treatment of psoriasis. 24,37 The research on molecular targets and mechanisms of natural products has greatly contributed to the progress in the treatment of skin diseases.…”

Analysis of association between cytokine gene polymorphisms and psoriatic disease in Russians of East Siberia

“…The main characteristics of psoriasis are excessive proliferation of keratinocytes and being easy to relapse; however, it was reported that the disease can affect many tissues in the muscles, joints, digestive tract and even eyes. Therefore, it is agreed that PS is one of the forms of psoriatic disease (PD) (Ritchlin, 2007;Meng et al, 2018). Psoriasis possesses a major social and economic burden on society as the existent therapies only relieve symptoms and cannot cure disease.…”

Auricular acupressure as a complementary therapy for psoriasis vulgaris: study protocol for a multicenter randomized controlled trial

“…Finally, qi and blood coagulated and blocked the meridians, which led to lack of nourishment for the skin and muscle. Thus, TCM clinical experts advocated 'treatment of psoriasis from the blood aspect' [11,12]. The effective ways to achieve this are blood-activating herbal medicines and treatments such as acupuncture and bloodletting.…”