Psoriasis

Abstract

Psoriasis is an immune-mediated, genetic disease manifesting in the skin or joints or both. A diverse team of clinicians with a range of expertise is often needed to treat the disease. Psoriasis provides many challenges including high prevalence, chronicity, disfiguration, disability, and associated comorbidity. Understanding the role of immune function in psoriasis and the interplay between the innate and adaptive immune system has helped to manage this complex disease, which affects patients far beyond the skin. In this Seminar, we highlight the clinical diversity of psoriasis and associated comorbid diseases. We describe recent developments in psoriasis epidemiology, pathogenesis, and genetics to better understand present trends in psoriasis management. Our key objective is to raise awareness of the complexity of this multifaceted disease, the potential of state-of-the-art therapeutic approaches, and the need for early diagnosis and comprehensive management of patients with psoriasis.

SIRT1 activity is decreased in lesional psoriatic skin

“…Hence, psoriasis is associated with impairment in health related quality of life, and, recently, it has emerged as a systemic disease, which affects not only cutaneous and articular sites, but it can also result in metabolic impairments and adverse cardiovascular outcomes [1]. Cytokines and growth factors released by activated T cells have been shown to display a prominent role in keratinocyte hyperproliferation; however, we focused our attention on dermal fibroblasts, which are also directly involved in the developing psoriatic lesions accelerating keratinocyte proliferation [1].…”

“…Cytokines and growth factors released by activated T cells have been shown to display a prominent role in keratinocyte hyperproliferation; however, we focused our attention on dermal fibroblasts, which are also directly involved in the developing psoriatic lesions accelerating keratinocyte proliferation [1].…”

MicroRNA‑520a suppresses the proliferation and mitosis of HaCaT cells by inactivating protein kinase B

“…They are commonly located on the scalp, around the navel, shin and the back of the forearms (24,25). Genetic factors associated with the immune reaction of skin cells serve a role in the pathogenesis of psoriasis, which may be affected by the environment, psychological stress or infections (22)(23)(24). However, the mechanisms of the pathogenesis of psoriasis remain unclear; therefore, further study is required.…”

“…However, the mechanisms of the pathogenesis of psoriasis remain unclear; therefore, further study is required. Furthermore, cardiovascular disease, lymphomas, psoriatic arthritis, depression and Crohn's disease may increase the risk of psoriasis (24).…”

Assessment of Level of Knowledge and Beliefs Toward Psoriasis Among Community In Almadina Almonawara City, 2016.

“…Although there is a suggestion that psoriasis could be an autoimmune disease, no auto-antigen that could be responsible has been defined yet. Psoriasis can also be provoked by external and internal triggers, including mild trauma, sunburn, infections, systemic drugs and stress [5] . Psoriasis involves the skin and nails, and is associated with a number of comorbidities.…”