Psoriatic Arthritis in Males and Females: Differences and Similarities

Abstract

Objective: To assess any differences and similarities in psoriatic arthritis (PsA) between sexes. Any possible differences of psoriasis and its potential impact on disease burden between sexes with PsA were also evaluated. Methods: Cross-sectional analysis of two longitudinal PsA cohorts. The impact of psoriasis on the PtGA was evaluated. Patients were stratified in four groups based on BSA. The median PtGA was then compared between the four groups. Moreover, a multivariate linear regression analysis was performed in order to evaluate associations between PtGA and skin involvement, split by sexes. Results: We enrolled 141 males and 131 females: PtGA, PtPnV, tender, swollen joint count, DAPSA, HAQ-DI, PsAID-12 were statistically significant higher in females (p B 0.05). PASS ''yes'' was deemed more in males than in females and BSA was higher in males. MDA was present more in males than females. When the patients were stratified on BSA, median PtGA was not different between males and females with BSA = 0. Instead, in females with BSA [ 0, a higher PtGA was observed compared to males with BSA [ 0. There was not a statistically significant association between skin involvement and PtGA at linear regression analysis, even if a trend seems to be present in female. Conclusions: Psoriasis is more present in males, but it seems to be related to a worse impact in females. In particular, a possible role of psoriasis as an influencing factor the PtGA was found. Moreover, female PsA patients tended to have more disease activity, worse function, and higher disease burden.

Retention rate of tumor necrosis factor inhibitors, anti-interleukin 17, and anti-interleukin 12/23 drugs in a single-center cohort of psoriatic arthritis patients

“…In our population, the prevalence of fibromyalgia in PsA patients reflects what is reported in the literature, even though prevalence rates may vary when using different criteria or tools for fibromyalgia detection (40,41) (43)(44)(45). To the best of our knowledge, there are very few studies reporting comorbidity impact on bDMARDs withdrawal in PsA.…”

Psoriasis Area and Severity Index and its Correlation with Liver Function Test

“…This study aimed to assess the Psoriasis Area and Severity Index (PASI) score and its correlation with liver function test (LFT) values in 102 psoriasis patients, with an average age of 44.81 ± 11.10 years and the study population comprised predominantly males (74.5%), with females accounting for 25.5% of the participants. In the comparison of this study Lubrano E et al 15 reported that the males were 51.8% and females were 48.2% with an overall mean age of 55.68+12.43 years. Consistently, in a study conducted by Sultan N et al 16 also it was reported that out of 140 patients, 87 (62%) were male and 53 (38%) were female, with a mean age of 40.97 ± 14.74 years.…”

Psoriatic Arthritis Involving TMJ: A Review on Pathogenesis and Consideration on Eventual Gender Differences

“…Some studies suggest that males with PsA may experience more severe joint inflammation and damage, leading to increased disability and functional impairment. Females, on the other hand, may be more likely to report higher levels of pain, fatigue, and psychological distress associated with PsA [40]. However, these findings are not consistent across all studies, and further research is needed to fully elucidate the gender-specific differences in disease severity.…”

“…Males tend to present with more peripheral joint involvement, such as inflammation of the larger joints, including the knees, ankles, and wrists. On the other hand, females often exhibit a higher prevalence of axial involvement, which includes the spine, sacroiliac joints, and TMJ [40]. The reasons for this variation in joint involvement patterns between genders are not well understood and may be influenced by both hormonal and genetic factors.…”