“…Classic psychedelics are a family of drugs whose central mode of action is through the 2A receptor of the serotonergic system (Nichols, 2016). Their effect is known to be context-dependent Hartogsohn, 2017;Hartogsohn, 2020), and they are known to produce a myriad of intense experiences (Harner, 1973;Grof, 1975Grof, /2016Shanon, 2002), including so-called mystical-type and ego-dissolution experiences (Pahnke and Richards, 1966;Griffiths et al, 2008;Nour et al, 2016), emotional breakthrough, release or catharsis and psychological processing of traumatic events (Frederking, 1955;Riba et al, 2006;Gasser et al, 2014;Belser et al, 2017;Roseman et al, 2019), challenging high-anxiety experiences (Carbonaro et al, 2016), prophetic-type experiences (Strassman, 2014), visionary and hallucinatory experiences (Knauer and Maloney, 1913;Klüver, 1926;Reichel-Dolmatoff, 1975;Luna andAmaringo, 1991/1999;Shanon, 2002;Roseman, 2019), and experiences of social connection (Dolder et al, 2016;Pokorny et al, 2017;Apud, 2020b;Forstmann et al, 2020;Kettner et al, 2021). The context-dependent quality of psychedelics has led them to be referred as 'non-specific amplifiers' (Grof, 1975(Grof, / 2016)meaning they intensify whatever is in the vicinity of the experiencer, whether good or bad or intrinsically (e.g., in their own mind) or extrinsically located (i.e., in their immediate environment).…”