Psychiatric adverse effects induced by recombinant interferon alfa in patients with chronic hepatitis C

Nesic, I Zorica; Delic, Dragan; Prostran, S Milica; Stojanovic, M Radan; Vučković, Marijana; Todorović, Zoran

doi:10.2298/mpns0406219n

Cited by 6 publications

(5 citation statements)

References 20 publications

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“…However, a previous study showed that being female was a risk factor for development of depression only in the early phase of PEG-IFN-α treatment (31). Another study also showed that females had more psychiatric side effects at PEG-IFN-α (32). However, some previous studies did not find any significant relationship between gender and depression in PEG-IFN-α therapy (33).…”

Section: Discussionmentioning

confidence: 99%

A Survey on the Prevalence of Depression in Blood Donors with Hepatitis C in Shiraz

Kasraian

Negarestani

Karimi³

et al. 2016

Hepat Mon

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BackgroundDepression is the most common psychiatric disorder associated with hepatitis C.ObjectivesThis study aimed to survey the prevalence rate of depression in patients with Hepatitis C Virus (HCV) before they were aware of their HCV test result.MethodsThis cross-sectional study was conducted on all blood donors with confirmed positive HCV test results who donated blood between March 21, 2012 to March 21, 2013 at Fars blood transfusion center in Iran as case group and age- and sex-matched blood donors with negative screening test results as control group. A semi-structured interview based on DSM IV-TR depressive disorder criteria and Beck depression inventory (BDI) was conducted. BDI contained 21 items, each scored from 0 to 3 and total score of 0 to 63 for the whole scale computed by summing up all the items. A cut-off score of ≥ 19 indicated clinically significant depressive symptoms. The prevalence rate and risk factors of depression were determined.ResultsThe most frequent risk factors for HCV infection were intravenous drug abuse (59.3%), unsafe sexual contact (30.5%), and history of being imprisoned (25.4%). The prevalence rate of depression in the HCV group was 55.9 % (95% CI: 42.99% - 68.87%) that was significantly higher than the corresponding rate of the control group as 17.7 % ( 95% CI: 8.49% - 28.79%) (P < 0.001). The severity of depression was also more in the HCV group (P < 0.001). Besides, the prevalence rate of depression was higher among HCV patients with lower education level, previous history of drug abuse, unsafe sexual contact, and previous history of psychiatric diseases. The prevalence rate of depression was higher in the case group even after adjusting for other variables.ConclusionsOur study underlined the remarkable prevalence of depression among HCV patients. Therefore, designing depression screening tests is suggested to help such patients before starting the treatment.

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Section: Discussionmentioning

confidence: 99%

A Survey on the Prevalence of Depression in Blood Donors with Hepatitis C in Shiraz

Kasraian

Negarestani

Karimi³

et al. 2016

Hepat Mon

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“…Interferon therapy for patients with CHC is associated with significant psychiatric side‐effects, such as depression . Previous studies showed that the median time required for the appearance or worsening of the depressive symptoms was 15 days .…”

Section: Discussionmentioning

confidence: 99%

“…associated with significant psychiatric side-effects, such as depression. 20 Previous studies showed that the median time required for the appearance or worsening of the depressive symptoms was 15 days. 21 In this study, however, during the 12-week therapy, minor depressive symptoms were found in 1 of the 10 patients with CHC and this patient did not manifest a worsening of depressive symptoms.…”

Section: Nterferon Therapy For Patients With Chc Ismentioning

confidence: 99%

Reduced frontal activation during verbal fluency task in chronic hepatitis C patients with interferon‐based therapy as measured by near‐infrared spectroscopy

Abe

Wada

Oshima

et al. 2016

Hepatology Research

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Aim: Psychiatric side-effects are the main reason for discontinuation of interferon (IFN)-based therapy. Recent developments in near-infrared spectroscopy (NIRS) have enabled non-invasive clarification of brain functions in psychiatric disorders. We prospectively evaluated brain activation in 20 chronic hepatitis C patients with or without IFN-based therapy by using NIRS during a verbal fluency task (VFT). Methods:The relative concentrations of oxygenated hemoglobin were measured while patients completed a questionnaire survey at the start of treatment and at 4 and 12 weeks during treatment, using NIRS. Results:The VFT performance did not change among the two groups. Patients with IFN-based therapy showed significantly lower activation during VFT in frontal channels at 12 weeks than those at the start of treatment and control (P < 0.05). Their Center for Epidemiologic Studies Depression Scale scores were significantly higher at 12 weeks than those at the start of treatment, although major depressive symptoms were not found (8.3 ± 7.9 vs. 13.2 ± 6.0, P < 0.001). Conclusion:The decrease in oxygenated hemoglobin concentrations of the frontal lobe detected using NIRS in this study reflects hypofunction of the frontal lobe. This functional decline that was caused by IFN-based therapy may be associated with the prodromal phase of depression.

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“…The link between immune system, inflammation and depression was observed for the first time when IFN–α therapies, which activate inflammatory antiviral response, were introduced as a treatment for hepatitis C. Patients treated with interferon developed depression-like behaviors after 4 weeks of treatment initiationinitiation [ 92 ]. Patients with MDD have been observed to have higher levels of pro-inflammatory mediators such as IL–6, IL–12 and C–reactive protein compared to nondepressed individuals [ 93 , 94 ].…”

Section: Anti-inflammatory Activity Of Medicinal Mushrooms In Beating...mentioning

confidence: 99%

Discovering the Potential Mechanisms of Medicinal Mushrooms Antidepressant Activity: A Review

et al. 2023

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Major Depression Disease is a common mental illness that affects more than 322 million people worldwide and it is one of the leading causes of mental and physical disability. The etiology of depression is a complex interplay of psychological, social, and biological factors. Currently, psychopharmacotherapy is based mainly on the monoamine theory, which states that depression is caused by an insufficient level of monoamines such as serotonin, norepinephrine, and/or dopamine. Due to the relatively low efficacy of the typical antidepressant and the high prevalence of treatment-resistant depression (~30%), seeking new ways of prophylaxis, adjuvant therapy, or novel compounds with antidepressant activity, is a priority. According to studies that analyzed mushroom consumption patterns and depression prevalence, it was concluded that mushroom ingestion lowers the odds of depression. Medicinal mushrooms are considered functional foods because of their ability to synthesize and accumulate different types of metabolites, which enhance their health-promoting properties. The review aims to explain the antidepressant activity of edible/medicinal mushrooms by elucidating the mechanism from different perspectives: edible mushrooms as a source of serotonin precursors and psilocybin as a rapid-acting antidepressant. These compounds exhibit anti-neuroinflammatory and antioxidant activities that impact neurotrophin expression, the neurogenesis process, and influence on the gut–brain axis.

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Psychiatric adverse effects induced by recombinant interferon alfa in patients with chronic hepatitis C

Abstract: Interferon causes psychiatric disorders that are usually mild and reversible. They disappear either spontaneously, while patients are still receiving therapy or after temporary cessation of interferon alfa therapy.

Cited by 6 publications

References 20 publications

A Survey on the Prevalence of Depression in Blood Donors with Hepatitis C in Shiraz

A Survey on the Prevalence of Depression in Blood Donors with Hepatitis C in Shiraz

Reduced frontal activation during verbal fluency task in chronic hepatitis C patients with interferon‐based therapy as measured by near‐infrared spectroscopy

Discovering the Potential Mechanisms of Medicinal Mushrooms Antidepressant Activity: A Review

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