Psychiatric and Cognitive Effects of Deep Brain Stimulation for Parkinson’s Disease

Nassery, Adam; Palmese, Christina A.; Sarva, Harini; Groves, Mark; Miravite, Joan; Kopell, Brian H.

doi:10.1007/s11910-016-0690-1

Cited by 22 publications

(16 citation statements)

References 98 publications

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“…[ 5 ] Evidence about the effects of DBS on nonmotor symptoms in PD is still sparse and under debate. [ 6 – 8 ] The aim of our open, prospective, single institution study was to assess the initial impact of DBS on motor and nonmotor symptoms of advanced PD. The data were collected during four-month follow-up in 24 patients with advanced, fluctuating PD who underwent STN-DBS surgery.…”

Section: Introductionmentioning

confidence: 99%

Bilateral subthalamic deep brain stimulation initial impact on nonmotor and motor symptoms in Parkinson's disease

Kurčová

Bardoň²,

Vaštík³

et al. 2018

Medicine

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Numerous studies document significant improvement in motor symptoms in patients with Parkinson's disease (PD) after deep brain stimulation of the subthalamic nucleus (STN-DBS). However, little is known about the initial effects of STN-DBS on nonmotor domains.Our objective was to elucidate the initial effects of STN-DBS on non-motor and motor symptoms in PD patients in a 4-month follow-up.This open prospective study followed 24 patients with PD who underwent STN-DBS. The patients were examined using dedicated rating scales preoperatively and at 1 and 4 months following STN-DBS to determine initial changes in motor and nonmotor symptoms. Patients at month 1 after STN-DBS had significantly reduced the Parkinson's disease Questionnaire scores (P = .018) and Scales for Outcomes in Parkinson's disease – Autonomic scores (P = .002); these scores had increased at Month 4 after DBS-STN. Nonmotor Symptoms Scale for Parkinson's Disease had improved significantly at Month 1 (P < .001); at Month 4, it remained significantly lower than before stimulation (P = .036). There was no significant difference in The Parkinson's Disease Sleep Scaleat Month 1 and significant improvement at Month 4 (P = .026). There were no significant changes in The Female Sexual Function Index or International Index of Erectile Function. Movement Disorder Society Unified Parkinson's Disease Rating Scale, Part III scores show significant improvements at Month 1 (P < .001) and at Month 4 (P < .001).STN-DBS in patients with advanced PD clearly improves not only motor symptoms, but also several domains of nonmotor functions, namely sleep, autonomic functions and quality of life quickly following the start of stimulation.

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Section: Introductionmentioning

confidence: 99%

Bilateral subthalamic deep brain stimulation initial impact on nonmotor and motor symptoms in Parkinson's disease

Kurčová

Bardoň²,

Vaštík³

et al. 2018

Medicine

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“…Alternative pharmacological approaches that target cholinergic or adenosine receptor systems do not relieve symptoms to the same degree. Deep brain stimulation (DBS) is effective for many patients, but this method is not appropriate for all patients, and there are issues with the long-term effectiveness of the implanted electrodes due to impedance changes (Nassery et al, 2016; Okun, 2012; Satzer et al, 2020; Voon et al, 2013). Other commonly reported side effects include impairment of axial motor performance and cognition, along with mood effects including apathy, anxiety, impulsiveness, and depressive symptoms (Hartmann et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Persistent Relief of Motor Symptoms in a Parkinsonian Mouse Model After Induction of LTD at Cortical Inputs to Indirect Pathway Striatal Neurons

Abburi

Thome

Rodriguez

et al. 2022

Preprint

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In Parkinson's disease (PD) patients, dopamine replacement therapy requires days to reach maximal effects, and the return of symptoms without treatment is similarly delayed. We previously postulated that these phenomena are mediated by plasticity of coritcostriatal synapses. As dopamine depletion is expected to promote aberrant potentiation of the cortical inputs onto indirect pathway neurons, we reasoned that induction of LTD here could reduce motor deficits in a PD model. Optogenetic cortical stimulation combined with a D2 receptor agonist, quinpirole, induces robust optical LTD (oLTD) in brain slices from 6-OHDA lesioned mice. When lesioned mice were subjected to corticostriatal oLTD treatment over 5 days, motor performance was improved for >3 weeks. Consistent with LTD induction, oLTD-treated mice had reduced VGLUT1 expression in striatum and greater excitability of D2 neurons. These findings suggest that reversing aberrant corticostriatal synaptic plasticity in the indirect pathway may lead to persistent relief of PD motor symptoms.

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“…It is also used in brain-injured patients in vegetative and minimally conscious states [104]. Although therapeutic DBS is applied along with the rules of the art and ethics [105], its use can be accompanied by psychiatric complications [106,107]. The neural mechanisms underlying the effects of DBS are complex and little known [108,109].…”

Section: Overview Of Therapeutic Neurophysiological Procedures: Dbmentioning

confidence: 99%

A Neurophysiological Perspective on a Preventive Treatment against Schizophrenia Using Transcranial Electric Stimulation of the Corticothalamic Pathway

Pinault

2017

Brain Sciences

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Schizophrenia patients are waiting for a treatment free of detrimental effects. Psychotic disorders are devastating mental illnesses associated with dysfunctional brain networks. Ongoing brain network gamma frequency (30–80 Hz) oscillations, naturally implicated in integrative function, are excessively amplified during hallucinations, in at-risk mental states for psychosis and first-episode psychosis. So, gamma oscillations represent a bioelectrical marker for cerebral network disorders with prognostic and therapeutic potential. They accompany sensorimotor and cognitive deficits already present in prodromal schizophrenia. Abnormally amplified gamma oscillations are reproduced in the corticothalamic systems of healthy humans and rodents after a single systemic administration, at a psychotomimetic dose, of the glutamate N-methyl-d-aspartate receptor antagonist ketamine. These translational ketamine models of prodromal schizophrenia are thus promising to work out a preventive noninvasive treatment against first-episode psychosis and chronic schizophrenia. In the present essay, transcranial electric stimulation (TES) is considered an appropriate preventive therapeutic modality because it can influence cognitive performance and neural oscillations. Here, I highlight clinical and experimental findings showing that, together, the corticothalamic pathway, the thalamus, and the glutamatergic synaptic transmission form an etiopathophysiological backbone for schizophrenia and represent a potential therapeutic target for preventive TES of dysfunctional brain networks in at-risk mental state patients against psychotic disorders.

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Psychiatric and Cognitive Effects of Deep Brain Stimulation for Parkinson’s Disease

Cited by 22 publications

References 98 publications

Bilateral subthalamic deep brain stimulation initial impact on nonmotor and motor symptoms in Parkinson's disease

Bilateral subthalamic deep brain stimulation initial impact on nonmotor and motor symptoms in Parkinson's disease

Persistent Relief of Motor Symptoms in a Parkinsonian Mouse Model After Induction of LTD at Cortical Inputs to Indirect Pathway Striatal Neurons

A Neurophysiological Perspective on a Preventive Treatment against Schizophrenia Using Transcranial Electric Stimulation of the Corticothalamic Pathway

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