Psychiatric and physical outcomes of long-term use of lithium in older adults with bipolar disorder and major depressive disorder: A cross-sectional multicenter study

Morlet, Élise; Costemale-Lacoste, Jean-François; Poulet, Emmanuel; McMahon, Kibby; Hoertel, Nicolas; Limosin, Frédéric; Adès, J.; Alezrah, Charles; Amado, Isabelle; Amar, G.; Andrei, Oana Cella; Arbault, D.; Archambault, Gary; Aurifeuille, G.; Barrière, Sarah; Béra-Potelle, Céline; Blumenstock, Yvonne; Bardou, H.; Bareil-Guérin, M.; Barrau, P.; Barrouillet, C.; Baup, E.; Bazin, Nadine; Beaufils, B.; Ayed, J. Ben; Benoît, Maryse; Benyacoub, K.; Bichet, T.; Blanadet, F.; Blanc, O.; Blanc-Comiti, J.; Boussiron, Didier; Bouysse, A.-M.; Brochard, A; Brochart, O.; Bucheron, B.; Cabot, M.; Camus, Vincent; Chabannes, J.-M.; Charlot, Véronique; Charpeaud, Thomas; Clad-Mor, C.; Combes, Céline; Comisu, M.; Cordier, B.; Costi, F.; Courcelles, J. P.; Creixell, M.; Cuché, H; Cuervo-Lombard, Christine; Dammak, A; Rin, D. Da; Denis, JB; Denizot, H.; Deperthuis, A.; Diers, E.; Dirami, S.; Donneau, D.; Dreano, P.; Dubertret, Caroline; Duprat, E.; Duthoit, Didier; Fernandez, Christine; Fonfrede, P.; Freitas, Noélle de Oliveira; Gasnier, P.; Gauillard, J.; Getten, F.; Gierski, Fabien; Godart, François; Gourévitch, Raphaël; Delyle, A. Grassin; Gremion, J.; Gres, H; Griner, Véronique; Guérin-Langlois, Christophe; Guggiari, C.; Guillin, Olivier; Hadaoui, H.; Haffen, E.; Hanon, Cécile; Haouzir, S.; Hazif‐Thomas, Cyril; Heron, A.; Hubsch, B.; Jalenques, Isabelle; Januel, Dominique; Kaladjian, Arthur; Karnycheff, J. F.; Kébir, Oussama; Krebs, M O; Lajugie, Christine; Leboyer, Marion; Legrand, P.; Lejoyeux, Michel; Lemaire, Vincent; Leroy, E.; Lévy-Chavagnat, Diane; Leydier, A.; Liling, C.; Llorca, P.M.; Loeffel, P.; Louville, P.; Lucas, Stéphane; Mages, N.; Mahi, M.; Maillet, Olivier; Manetti, Aude; Martelli, Catherine; Martín, Pilar Barreto; Masson, Marjolaine; Maurs-Ferrer, I.; Mauvieux, J.; Mazmanian, S.; Mechin, E.; Mekaoui, Lila; Meniai, M.; Metton, A.; Mihoubi, Alain; Mirón, María Luisa Limón; Mora, G; Ades, Veronica; Nubukpo, Philippe; Omnès, Cécile; Papin, Stéphanie; Paris, P.; Passerieux, Christine; Pellerin, J.; Perlbarg, Julie; Perron, Stéphane; Petit, Ariane; Petitjean, François; Portefaix, Christophe; Pringuey, D.; Radtchenko, A.; Rahiou, H.; Raucher‐Chéné, Delphine; Rauzy, Antoine; Reinheimer, L.; Renard, M; René, Margaux; Rengade, C.-E.; Reynaud, Philippe; Robin, Donald A.; Rodrigues, Christelle; Rollet, A.; Rondepierre, Fabien; Rousselot, B.; Rubingher, S.; Saba, Ghassen; Salvarelli, J.P.; Samuelian, J. C.; Scemama-Ammar, C.; Schürhoff, Franck; Schuster, J P; Sechter, D.; Segalas, B.; Seguret, T.; Seigneurie, Anne-Sophie; Semmak, A.; Slama, Frédéric; Taisne, S.; Taleb, M; Terra, J. L.; Thefenne, D.; Tran, Eric; Tourtauchaux, R.; Vacheron, M.N.; Vandel, Pierre; Vanhoucke, V.; Venet, E.; Verdoux, Hélène; Viala, A; Vidon, Gilles; Vitre, M. T.; Vurpas, JL; Wagermez, C.; Walter, Michel; Yon, Liova; Zendjidjian, X.

doi:10.1016/j.jad.2019.08.056

Cited by 17 publications

(8 citation statements)

References 85 publications

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“…Longitudinal data were drawn from the CSA study, a cohort of 634 older people, aged 57–92 years (mean age = 67.9 years, SD = 7.2) with an ICD‐10 (International Classification of Diseases, Tenth edition) diagnosis of schizophrenia ( n = 353), bipolar disorder ( n = 139) or major depressive disorder ( n = 142). A more detailed description of the study methodology can be found elsewhere 1–9 . Participants were recruited between February 2010 and June 2013 from 63 French state hospital psychiatric departments, each of them covering one mutually independent catchment area 7,10–12 .…”

Section: Methodsmentioning

confidence: 99%

“…2 In fact, studies in adult psychiatric patients consistently highlight premature mortality, increased prevalence of cardiovascular diseases and their close association with metabolic syndrome. [2][3][4][5][6][7] However, in older psychiatric patients, only one study explored the relation between metabolic syndrome and mortality and its results were not in line with those of studies of younger adults with psychiatric disorders. 8 The discrepancy in findings related to metabolic syndrome and mortality between younger and older adults were initially noted in general population samples.…”

Section: Introductionmentioning

confidence: 95%

“…A more detailed description of the study methodology can be found elsewhere. [1][2][3][4][5][6][7][8][9] Participants were recruited between February 2010 and June 2013 from 63 French state hospital psychiatric departments, each of them covering one mutually independent catchment area. 7,[10][11][12]…”

Section: Samplementioning

confidence: 99%

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Metabolic syndrome and risk of death in older adults with major psychiatric disorders: Results from a 5‐year prospective multicenter study

Kassm

Sánchez‐Rico

Naja

et al. 2022

Int J Geriat Psychiatry

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Objectives:No study has explored the association of individual components of metabolic syndrome with mortality in older patients with psychiatric disorders. In this report, we examined whether metabolic syndrome or any of its components predicted mortality in a cohort of older adults with psychiatric disorders. Methods:We used data from a multicenter 5-year prospective cohort, including 634 in-and out-patients with schizophrenia, bipolar or major depressive disorder.Metabolic syndrome was assessed at baseline following NCEP-ATPIII criteria. Cause of death was categorized as cardiovascular disorder (CVD) mortality, non-CVD disease-related mortality (e.g., infections), suicide and accident.Results: 122 participants (44.0%) were diagnosed with metabolic syndrome at baseline. In the full sample, there was no significant association between metabolic syndrome or any of its components with all-cause, CVD and non-CVD mortality.However, for the subpopulation of older adults with major depressive disorder, metabolic syndrome was significantly associated with increased all-cause and disease-related mortality after adjustment for age, sex and smoking status (p = 0.032 and p = 0.036, respectively). There was a significant interaction between metabolic syndrome and psychiatric diagnoses indicating that in participants with major depressive disorder, metabolic syndrome had a significantly greater effect on all-cause mortality (p = 0.025) and on disease-related mortality (p = 0.008) than in participants with either bipolar disorder or schizophrenia.The collaborators in CSA Study group are, J.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 95%

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Metabolic syndrome and risk of death in older adults with major psychiatric disorders: Results from a 5‐year prospective multicenter study

Kassm

Sánchez‐Rico

Naja

et al. 2022

Int J Geriat Psychiatry

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“…Cross‐sectional data were drawn from the CSA study, a cohort of 353 in‐ (34.1%) or outpatients (65.9%) aged 55 years or more with an International Classification of Diseases, 10th edition (ICD‐10) diagnosis of schizophrenia (82.4%) or schizoaffective disorder (17.6%). More detailed description of the study methodology can be found elsewhere 25–31 . Participants were recruited between February 2010 and June 2013 from 63 French state hospital psychiatric departments, each of them covering one mutually independent catchment area 32 .…”

Section: Methodsmentioning

confidence: 99%

“…In this report, we sought to examine potential differences between patients of similar age with LOS and NLOS as to sociodemographic and clinical characteristics of schizophrenia, comorbidity, psychotropic medications, quality of life, functioning, and mental health care utilization. To this purpose, we took advantage of the Cohort of older adults with Schizophrenia Aged 55 years or more (CSA) study, 25–30 a multicenter sample of 353 older adults with schizophrenia or schizoaffective disorder.…”

Section: Introductionmentioning

confidence: 99%

Late‐onset and nonlate‐onset schizophrenia: A comparison of clinical characteristics in a multicenter study

Kassm

Limosin

Naja

et al. 2021

Int J Geriat Psychiatry

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Objectives Data are scarce regarding the potential clinical differences between non‐late onset schizophrenia (NLOS, i.e., disorder occurring before 40 years of age), late‐onset schizophrenia (LOS, occurring between ages 40 and 60 years) and very‐late‐onset schizophrenia‐like psychosis (VLOSLP, occurring after 60 years of age). Furthermore, previous research compared LOS patients with non‐age matched NLOS patients. In this study, we sought to examine potential clinical differences between patients of similar age with LOS and NLOS. Methods/Design This is a cross‐sectional multicentre study that recruited in‐ and outpatients older adults (aged ≥55 years) with an ICD‐10 diagnosis of schizophrenia or schizoaffective disorder with NLOS and LOS. Sociodemographic and clinical characteristics, comorbidity, psychotropic medications, quality of life, functioning, and mental health care utilization were drawn for comparison. Results Two hundred seventy‐two participants (79.8%) had NLOS, 61 (17.9%) LOS, and 8 (2.3%) VLOSLP. LOS was significantly and independently associated with greater severity of emotional withdrawal and lower severity of depression (all p < 0.05). However, the magnitude of these associations was modest, with significant adjusted odds ratios ranging from 0.71 to 1.24, and there were no significant between‐group differences in other characteristics. Conclusion In an age‐matched multicenter sample of elderly patients with schizophrenia, older adults with LOS were largely similar to older adults with NLOS in terms of clinical characteristics. The few differences observed may be at least partially related to symptom fluctuation with time. Implications of these findings for pharmacological and nonpharmacological management is yet to be determined.

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Bipolar and Related Disorders

Mihalik-Wenger,

Suryadevara,

Wenger

et al. 2024

Age-Adjusted Psychiatric Treatment for the Older Patient

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Psychiatric and physical outcomes of long-term use of lithium in older adults with bipolar disorder and major depressive disorder: A cross-sectional multicenter study

Cited by 17 publications

References 85 publications

Metabolic syndrome and risk of death in older adults with major psychiatric disorders: Results from a 5‐year prospective multicenter study

Metabolic syndrome and risk of death in older adults with major psychiatric disorders: Results from a 5‐year prospective multicenter study

Late‐onset and nonlate‐onset schizophrenia: A comparison of clinical characteristics in a multicenter study

Bipolar and Related Disorders

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