Psychiatric comorbidity and suicidal ideation in psoriasis, melanoma and allergic disorders

Pompili, Maurizio; Innamorati, Marco; Forte, Alberto; Erbuto, Denise; Lamis, Dorian A.; Narcisi, Alessandra; Rea, Claudia; Orsini, Diego; D’Arino, Andrea; Arcese, Annalisa; Bellini, Samantha; Trovarelli, Sara; Serafini, Gianluca; Amore, Mario; Costanzo, Antonio; Girardi, Paolo

doi:10.1080/13651501.2017.1301482

Cited by 30 publications

(20 citation statements)

References 37 publications

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“…In Gupta et al's study, the risk of completed suicide when biologics were used for psoriasis was significantly greater than that when biologics were used for any other indication (OR 1.47; 95% CI 1.03–2.11) (Gupta et al, ). This suggests an inherent, increased risk of suicidality in psoriasis, as reported by several epidemiologic studies (Dalgard et al, ; Kurd et al, ; Pompili et al, ; Pompili et al, ; Singh et al, ; Zachariae et al, ), independent of biologic therapy. Therefore, the observed incidences of SIB in psoriasis patients on biologics may ultimately reflect an underlying epiphenomenon.…”

Section: Psoriasis and Suicidalitymentioning

confidence: 68%

“…Original sources cited within articles were retrieved when necessary. English‐language articles examining the association of psoriasis with various aspects of suicidality were identified (Table ) (Abuabara et al, ; Chi et al, ; Dalgard et al, ; Egeberg et al, ; Friedman et al, ; Gupta et al, ; Gupta & Gupta, ; Kimball et al, ; Kimball et al, ; Krueger et al, ; Kurd et al, ; Lamb et al, ; Picardi et al, ; Pompili et al, ; Pompili et al, ; Rapp et al, ; Sanna et al, ; Sharma et al, ; Singh et al, ; Singhal et al, ; Svedbom et al, ; Wu et al, ; Zachariae et al, ).…”

Section: Methodsmentioning

confidence: 99%

“…In another study of 113 Danish psoriasis patients, an even higher percentage (21.2%) reported thoughts about suicide (vs. 6.8% in individuals without the disease) (Zachariae et al, ). Furthermore, there is a high prevalence of lifetime SI in psoriasis patients, with as many as 37.4% reporting a history of SI (vs. 16.7% in patients without psoriasis) (Pompili et al, ; Pompili et al, ).…”

Section: Psoriasis and Suicidalitymentioning

confidence: 99%

“…Several studies suggest a relationship between psoriasis and an increased risk of suicidality (Dalgard et al, ; Kurd et al, ; Singh et al, ; Zachariae et al, ), with psoriasis having a stronger association with an increased risk than other dermatologic conditions (Gupta & Gupta, ; Picardi et al, ; Pompili et al, ; Pompili et al, ). However, other studies, including a recent population‐based cohort study of over 68,000 psoriasis patients, have not found a significant association (Abuabara et al, ; Egeberg et al, ; Kimball et al, ; Sanna et al, ; Svedbom et al, ; Wu et al, ).…”

Section: Psoriasis and Suicidalitymentioning

confidence: 99%

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Psoriasis and suicidality: A review of the literature

Liang

Cohen

2018

Dermatologic Therapy

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Psoriasis is a chronic systemic inflammatory skin disease, which has been associated with an increased risk of numerous medical and psychiatric comorbidities, including suicidality. Suicidality, which can be divided into the categories of suicidal ideation, suicide attempt, and completed suicide, is highly prevalent in the psoriasis population, and multiple studies have been published on the subject of psoriasis and suicidal ideation and behavior (SIB), including two recent metaanalyses. However, the available literature is limited and inconsistent, and the association between the two remains incompletely understood. The present review aims to cohesively synthesize and summarize the available evidence, while making a clinically relevant distinction between the sub-categories of suicidality, by examining not only the epidemiology of the association but also the plausible molecular mechanisms and the potential influence of biologic therapies. Additionally, this review aims to critically examine and understand the potential contribution of depression in the psoriasis and suicidality relationship. This will allow us to better understand the complex and multi-faceted relationship between psoriasis and suicidality, to identify those who may be most at risk for SIB, to make evidence-based clinical decisions regarding treatment and management, and to more completely address the needs of psoriasis patients. K E Y W O R D Spsoriasis, suicidal ideation and behavior, suicidality

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Section: Psoriasis and Suicidalitymentioning

confidence: 68%

Section: Methodsmentioning

confidence: 99%

Section: Psoriasis and Suicidalitymentioning

confidence: 99%

Section: Psoriasis and Suicidalitymentioning

confidence: 99%

See 2 more Smart Citations

Psoriasis and suicidality: A review of the literature

Liang

Cohen

2018

Dermatologic Therapy

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“…Psoriasis is a chronic, inflammatory, immune-mediated, skin disease that greatly affects health-related quality of life (HRQOL; Augustin and Radtke, 2014 ). Psoriasis is associated with negative psychosocial outcomes, including lower psychological well-being and higher psychological distress ( Offidani et al, 2016 ), psychiatric morbidity ( Pompili et al, 2017 ), cognitive impairment ( Innamorati et al, 2018 ), and impulse control difficulties ( Almeida et al, 2017 ). Systemic sclerosis (SSc) is an autoimmune connective tissue disease characterized by progressive vasculopathy and fibrosis of skin and internal organs ( Varga et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Positive Psychological Factors Are Associated With Better Spiritual Well-Being and Lower Distress in Individuals With Skin Diseases

et al. 2020

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In this study we examined whether aspects of positive functioning [reappraisal, sense of coherence (SOC), and positivity] were associated with spiritual well-being and psychological distress after controlling for negative functioning (skin-related symptoms, type of disease, and expressive suppression) in individuals with skin diseases. We also examined whether negative functioning aspects were linked to spiritual well-being and distress when controlling for aspects of positive functioning. The study used a cross-sectional design with a sample of 192 individuals with psoriasis and systemic sclerosis (SSc) ( M age = 51.6 years, SD = 16.5). Two hierarchical multiple regressions were conducted to determine whether spiritual well-being and psychological distress were accounted for by skin-related symptoms, type of disease, emotion regulation strategies, SOC, and positivity. Positivity was the most important contributor to better spiritual well-being, followed by both the comprehensibility/manageability and meaningfulness SOC subscales, after controlling for the other variables. High skin-related symptoms and expressive suppression were associated with lower psychological distress, whereas high SOC and reappraisal correlated with higher psychological distress. The findings of this study pave the way for further research on how SOC and positivity may reduce the effects of both skin-related symptoms and emotion dysregulation and facilitate spiritual well-being of individuals with skin diseases. Interventions aimed to enhance inner resources of these individuals and help them to find a meaning in their experience of skin disease might reduce psychological distress and improve spiritual well-being. Our findings suggest that healthcare professionals should consider positive functioning aspects in future interventions for individuals with skin diseases.

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The association between psoriasis and suicide

Ghani,

Tan,

Abramowitz

et al. 2023

Dermatological Reviews

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IntroductionThe pathophysiology of psoriasis and suicide has yet to be fully understood. This article explores the role of cytokines and psychoneuroimmunology in these diseases and describes the role of psychological assessment in psoriasis patients.Data SourcesA serach of literature was performed using the MEDLINE search engine and Google Scholar. English language articles were identified using the following serach terms: psoriasis and depression, psoriasis and suicide, self harm behaviors, inflammatory cytokines.ResultsSeveral observations and studies suggest that there is an underlying pathophysiological link between psoriasis and depression marked by elevated pro‐inflammatory markers. Research data indicate complex interactions between inflammation and cytokines. Immunomodulating drugs have anti‐inflammatory and immunomodulating effects. Preliminary clinical studies show that these agents may be beneficial in psoriasis and suicide, but their therapeutic value should be studied further.ConclusionPsychological assessment is an important step in screening, diagnosing, and managing depression leading to suicidal behavior in psoriasis patients.

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Psychiatric comorbidity and suicidal ideation in psoriasis, melanoma and allergic disorders

Abstract: The results from this study suggest that patients affected by psoriasis have an increased risk of psychiatric comorbidities and suicidal ideation compared to those who have other dermatological disorders.

Cited by 30 publications

References 37 publications

Psoriasis and suicidality: A review of the literature

Psoriasis and suicidality: A review of the literature

Positive Psychological Factors Are Associated With Better Spiritual Well-Being and Lower Distress in Individuals With Skin Diseases

The association between psoriasis and suicide

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