Psychiatric comorbidity, depression, and anxiety levels and quality of life of the patients with mycosis fungoides

Abstract

Mycosis fungoides (MF) is a chronic disease, causing serious morbidities and mortality. This study was designed to measure depression and anxiety levels in MF patients, and quality of life (QoL) assessments and to compare the results with controls. Fifty-two patients with a diagnosis of MF and 52 age and sex matching healthy controls were enrolled in this study. Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI) and the 36-Item Short Form Health Survey (SF-36) were administered to all patients and controls. Mean BAI and BDI scores of the patients with MF were significantly higher than controls. In case of the SF-36, general health perception, emotional, and social functioning scores were significantly lower in MF patients. Depression scores of the patients' were positively correlated with the age of disease onset and negatively correlated with physical functioning scores. Significant negative correlation was detected between eight subscales of the SF-36 and BDI and BAI scores. This study has demonstrated that there is significant impairment of QoL in MF patients MF, with higher anxiety and depression levels, when compared to control group. As the disease progresses, level of depression increases and patients' general health perception deteriorates.

Quality of life in patients with Mycosis Fungoides and Sézary Syndrome: a systematic review of the literature

“…In the 24 included studies in this review, QoL was reported for heterogeneous study populations with various stages of the disease and differences in prior‐ and current therapies 5,6,11–32 . The vast majority of studies described study populations that featured stage MF IA‐IVB and SS and did not report separate results for early and late‐stage disease (Table 1).…”

“…In total, 24 studies matched the eligibility criteria. 5,6, All included studies were published between 2001 and 2020.…”

“…No differences were observed in the different age groups. 25 DLQI scores of 6.3 (AE6.7), 3 [1][2][3][4][5][6][7][8][9][10]) and 12 (AE8)) were reported by studies describing divers populations of MF, although these numbers do indicate a small to moderate effect on general QoL in contrast to other studies. 11,21,27 Generic QoL The HRQoL measured with the EQ5D by Holahan et al was 0.83 (AE0.20), which correlated to a good health status.…”

“…26 General quality of life compared to healthy controls was significantly more affected in MF/SS. 6,13 Compared to a sex-and age-adjusted general population, patients with SS had lower general health, lower physical functioning, lower social functioning and lower vitality levels. 13 Compared to a matched healthy control group the mean depression and anxiety scores for patients with MF/SS were significantly lower.…”

“…Frequently reported symptoms are pain, itching, scaling and skin redness. Cutaneous lymphomas can, therefore, have a profound and severe impact on experienced Quality of Life (QoL) with regards to functioning, emotional‐ and social well‐being, with a high percentage of patients suffering from anxiety and high depression levels compared to healthy individuals 5,6 …”