Psychiatric comorbidity in children and youth with epilepsy: An association with executive dysfunction?

Alfstad, Kristin Å.; Torgersen, Halvor S.; Roy, Betty Van; Hessen, Erik; Hansen, Berit Hjelde; Henning, Oliver; Clench‐Aas, Jocelyne; Mowinckel, Petter; Gjerstad, Leif; Lossius, Morten I.

doi:10.1016/j.yebeh.2016.01.007

Cited by 43 publications

(47 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…As mentioned above, the BRIEF correlates highly with SDQ, which is associated with psychiatric symptoms. Thus, this finding is probably in line with our previous finding of high association between early seizure debut and psychiatric comorbidity (Alfstad et al., ). Most previous studies have not found this association (Alfstad et al., ).…”

Section: Discussionsupporting

confidence: 93%

See 1 more Smart Citation

Tested and reported executive problems in children and youth epilepsy

et al. 2018

Self Cite

View full text Add to dashboard Cite

ObjectivesExecutive problems in children and youth with epilepsy influence their ability to handle important aspects of daily life activities. The present study sought to explore factors associated with executive problems for patients with epilepsy in this age group.MethodsThe cohort consisted of 97 consecutive patients at the National Centre for Epilepsy in Norway, aged 10–19 years, with focal or genetic generalized epilepsy. All underwent tests of executive functions (D‐KEFS), the Behavior Rating Inventory for Executive Function (BRIEF), and screening for psychiatric symptoms, using the Strengths and Difficulties Questionnaire (SDQ).ResultsParent‐reported cognitive executive dysfunction (BRIEF, Metacognitive Index) was the strongest independent predictor for tested executive dysfunction and vice versa. Furthermore, male gender correlated strongest with parent‐reported behavioral regulation problems (BRIEF, Behavioral Regulation Index) along with borderline/pathological score on the SDQ and parent‐reported cognitive executive dysfunction.ConclusionsA strong association between parent‐reported cognitive executive dysfunction and tested executive dysfunction was found. Male gender correlated strongest with parent‐reported behavioral regulation problems. The latter was probably related to a higher frequency of symptoms associated with psychopathology among the boys than the girls. The frequency of executive deficits according to the different modes of measurement varied from 16% to 43%, suggesting that they capture different aspects of behavior under the executive umbrella.

show abstract

Section: Discussionsupporting

confidence: 93%

“…A detailed description of the inclusion and exclusion criteria in this study has been described elsewhere (Alfstad et al., ). All the patients underwent a 24‐hr EEG registration that was interpreted by a neurologist experienced in neurophysiology.…”

Section: Methodsmentioning

confidence: 99%

Tested and reported executive problems in children and youth epilepsy

et al. 2018

Self Cite

View full text Add to dashboard Cite

show abstract

“…Although some studies show a higher prevalence of ADHD among those with earlier age of epilepsy onset, the literature is conflicted on this topic. Alfstad and colleagues demonstrated that early onset of epilepsy increased the risk of developing psychiatric disorders overall, although the study did not specifically address ADHD alone (class II) . Similarly, a study of adolescents with epilepsy attending mainstream schools noted higher rates of ADHD in those with younger age at seizure onset (class II) .…”

Section: Resultsmentioning

confidence: 99%

Systematic review of the screening, diagnosis, and management of ADHD in children with epilepsy. Consensus paper of the Task Force on Comorbidities of the ILAE Pediatric Commission

et al. 2018

View full text Add to dashboard Cite

Attention-deficit/hyperactivity disorder (ADHD) is a common and challenging comorbidity affecting many children with epilepsy. A working group under the International League Against Epilepsy (ILAE) Pediatric Commission identified key questions on the identification and management of ADHD in children with epilepsy. Systematic reviews of the evidence to support approaches to these questions were collated and graded using criteria from the American Academy of Neurology Practice Parameter. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) requirements were followed, with PROSPERO registration (CRD42018094617). No increased risk of ADHD in boys with epilepsy compared to girls with epilepsy was found (Level A). Valproate use in pregnancy is associated with inattentiveness and hyperactivity in offspring (1 class I study), and children with intellectual and developmental disabilities are at increased risk of ADHD (Level A). Impact of early seizure onset on development of ADHD was unclear (Level U), but more evident with poor seizure control (Level B). ADHD screening should be performed from 6 years of age, or at diagnosis, and repeated annually (Level U) and reevaluated after change of antiepileptic drug (AED) (Level U). Diagnosis should involve health practitioners with expert training in ADHD (Level U). Use of the Strength and Difficulties Questionnaire screening tool is supported (Level B). Formal cognitive testing is strongly recommended in children with epilepsy who are struggling at school (Level U). Behavioral problems are more likely with polytherapy than monotherapy (Level C). Valproate can exacerbate attentional issues in children with childhood absence epilepsy (Level A). Methylphenidate is tolerated and effective in children with epilepsy (Level B). Limited evidence supports that atomoxetine is tolerated (Level C). Multidisciplinary involvement in transition and adult ADHD clinics is essential (Level U). In conclusion, although recommendations could be proposed for some of the study questions, this systematic review highlighted the need for more comprehensive and targeted large-population prospective studies.

show abstract

“…A terceira hipótese sugere que uma condição tem efeito causativo sobre a outra, por exemplo, o prejuízo das funções executivas tem sido frequentemente observado nas epilepsias focais (Bedoin et al, 2012;Filippini et al, 2016;Rai et al, 2015) e generalizadas (Gencpinar et al, 2016) e apontado como um fator de risco independente para doenças psiquiátricas na epilepsia, como o TDAH (Alfstad et al, 2016). Em consonância com a condição humana, os modelos animais de epilepsia sugerem a existência de uma associação entre os sintomas de TDAH e de epilepsia.…”

Section: Resultsunclassified

TDAH nas epilepsias: prevalência e fatores de risco

Pimentel

Cysneiros

2017

Psicologia - Teoria E Prática

View full text Add to dashboard Cite

Psychiatric comorbidity in children and youth with epilepsy: An association with executive dysfunction?

Cited by 43 publications

References 33 publications

Tested and reported executive problems in children and youth epilepsy

Tested and reported executive problems in children and youth epilepsy

Systematic review of the screening, diagnosis, and management of ADHD in children with epilepsy. Consensus paper of the Task Force on Comorbidities of the ILAE Pediatric Commission

TDAH nas epilepsias: prevalência e fatores de risco

Contact Info

Product

Resources

About