Psychiatric comorbidity in patients with substance use disorder: A hospital-based study

Gania, Ab Majid; Margoob, Mushtaq Ahmad; Shah, Hamid Ullah; Khan, Abdul Wahid; Ghosh, Abhishek; Basu, Debasish

doi:10.4103/0971-9962.200093

Cited by 7 publications

(6 citation statements)

References 2 publications

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“…Only 3% of the participants in our study had psychotic disorders. PTSD was found in 8.5% of our study participants, which was in line with the findings by Margoob MA et al 34 . These findings could be attributed to local political unrest that causes trauma and discontent.…”

Section: Discussionsupporting

confidence: 93%

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Psychiatric comorbidities and concurrent substance use among people who inject drugs: a single-centre hospital-based study

Kar,

Gania,

Bandy

et al. 2023

Sci Rep

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The management of people who inject drugs (PWID) is compounded by the presence of psychiatric comorbidities leading to frequent relapses and poor treatment outcomes. Early identification and treatment of psychiatric comorbidities should be included in the management to enhance treatment outcomes. The objective of this study was to estimate the prevalence of psychiatric comorbidities and concurrent substance use among opioid injectors. This hospital-based, cross-sectional study was conducted from March 2021 to August 2022. This study included opioid injectors of all ages and both sexes. The Mini International Neuropsychiatric Interview-7 (MINI-7) and WHO-ASSIST were used to determine psychiatric comorbidities and concurrent substance use, respectively. Both crude and adjusted odds ratios were calculated to assess associations among demographic variables, concurrent substance use and psychiatric comorbidities. Among the 328 opioid injectors, the overall prevalence of psychiatric comorbidities was 88.1%, with the majority (68.6%) having more than one comorbidity. The most common psychiatric comorbidities were panic disorder (41.2%), social anxiety disorder (40.5%), and antisocial personality disorder (39.3%). Concurrent use of alcoholic beverages doubled the risk of ASPD (odds ratio 2.14 (1.24–3.72)). Cocaine (odds ratio 2.36 (1.10–5.03)) and amphetamines (odds ratio 7.68 (2.21–26.65)) increased the risk of OCD. Daily heroin injections were negatively associated (odds ratio 0.18 (0.03–0.94)) with psychotic disorders. Younger age (adjusted odds ratio 0.20 (0.79–0.53)) and never married status (adjusted odds ratio 2.62 (1.06–6.47)) were the only significant variables in the regression analysis. In conclusion, opioid injectors had a higher prevalence of numerous psychiatric comorbidities. The most common comorbidity was anxiety disorders. Concurrent use of tobacco, cannabis, cocaine, inhalants, etc., greatly increased the risk of psychiatric comorbidities.

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Section: Discussionsupporting

confidence: 93%

“…Major depressive disorder was found in 17.7% of our study population. A similar prevalence of depressive disorder was found in the studies by Trouiller P et al 7 (21.3%), Margoob MA et al 34 , and Mary E. Mackesy-Amiti et al (25%) 7 , 23 . Only 3% of the participants in our study had psychotic disorders.…”

Section: Discussionsupporting

confidence: 79%

Psychiatric comorbidities and concurrent substance use among people who inject drugs: a single-centre hospital-based study

Kar,

Gania,

Bandy

et al. 2023

Sci Rep

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“…Various studies have shown similar findings of male presenting more with manic illness than females. Similar age and gender distribution was observed in a work by Gania et al, 11 Manning et al, studied 837 patients with particular concern with the problem of gambling and substance use in patients attending community health clinics in Australia. The mean age of the studied cases was found to be 38±13 years.…”

Section: Discussionsupporting

confidence: 72%

Study of reasons for relapse in patients with bipolar I disorder with repeat admissions and its correlation with substance use

et al. 2022

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Background: Mood disorder is one of the common causes, for which psychiatric consultations are sought. A better understanding of the factors that lead to repeated admissions, increased relapse rates, and concurrent substance dependence is necessary for the development of interventions that may reduce the likelihood of adverse effects in patient with bipolar I disorder. Aims and Objectives: The aims of this study were as follows: (1) To study the correlation between the reasons for relapse and substance use with various sociodemographic factors in patients having bipolar I disorders and (2) to find out the correlation between reasons for relapse, substance use, and severity of illness. Materials and Methods: This was a cross-sectional single interview study, in which 67 consecutive patients having bipolar I disorder and admitted in psychiatry ward were admitted on the basis of a pre-defined inclusion and exclusion criteria. The details about psychiatric, relapse-related symptoms, substance use-related symptoms, as well as other aspects of clinical profile were taken. Results: Out of 67 patients, 51 (76.1%) were male and 16 (23.8%) were female. Mean age of the participants was 30.43 years (S.D.=9.05). Sleep disturbance was seen in all patients (67) and was also the most common symptom. It was followed by psychomotor disturbances in 60 (89.5%) of the patients. Among 67 patients included in the study, substance use was seen among 28 (41.7%) of the patients. Substance use was significantly associated with age of the patients and occupation (P=0.03 each). The age group of more than 30 years (57.7%) had significantly higher substance use compared to those <30 years (31.7%). Conclusion: Concurrent substance use is associated with increased risk of relapse and readmissions in cases of patients with bipolar I disorders. A thorough history is necessary to rule out substance use in these cases.

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“…In contrast to above results, few studies reported psychotic disorder as most common co-morbidities followed by depressive disorders. Gania et al (2017) [19] found psychotic disorders 34%, depressive disorders 16% & 11.5% PTSD as common diagnoses in substance users while Balhara et al (2017) [20] found Psychotic disorders in 38.7% & depressive disorders in 27.5% as comorbidities in patients with substance related disorders but most of the studies reported depressive disorders and anxiety disorders as the most common comorbidities in substance abusers. This difference may be due to sampling method, selection criteria and type of substance used by the patients seeking the treatment for de-addiction therapy.…”

Section: Discussionmentioning

confidence: 99%

Psychiatric Comorbidities in Patients With Substance Use Disorders Coming for De-Addiction Treatment in a Tertiary Care Hospital of Western India

Agrawal¹,

Agrawal²

2018

jemds

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BACKGROUND Psychiatric comorbidities are common in patients with substance use disorder & they tend to complicate the management, course & prognosis of both disorders. So, this study was conducted in the M.B.S. Hospital of Govt. Medical College, Kota, to know the psychiatric comorbidities in patients with substance use disorder, coming for the de-addiction treatment in a tertiary care hospital of western India. MATERIALS & METHODS This is a case control study. 50 patients of substance use disorder were compared with the 50 age & sex matched controls & assessed by the especially designed semistructured performa, General Health Questionnaire & Indian Psychiatric Interview Schedule. Convenience sampling method was used for taking the sample. Data so collected was displayed in the form of various tables. Chi square test was used to test the significance. RESULTS 54% patients with substance use disorder were found to have co-morbid psychiatric diagnoses in comparison to 12% psychiatric morbidity in control group. In psychiatric co-morbidities, depressive disorder was the commonest diagnosis followed by anxiety disorder, personality disorder, bipolar disorder & schizophrenia spectrum disorders. CONCLUSION Effective management of psychiatric comorbidities is necessary for improvement in substance related behavioural & psychosocial outcomes. So the regular screening & management of psychiatric comorbidities should be the essential routine practice in deaddiction clinics & mental health care settings.

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Psychiatric comorbidity in patients with substance use disorder: A hospital-based study

Cited by 7 publications

References 2 publications

Psychiatric comorbidities and concurrent substance use among people who inject drugs: a single-centre hospital-based study

Psychiatric comorbidities and concurrent substance use among people who inject drugs: a single-centre hospital-based study

Study of reasons for relapse in patients with bipolar I disorder with repeat admissions and its correlation with substance use

Psychiatric Comorbidities in Patients With Substance Use Disorders Coming for De-Addiction Treatment in a Tertiary Care Hospital of Western India

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