Psychiatric comorbidity of patients on methadone maintenance treatment with a history of sexual abuse

Peles, Einat; Potik, David; Schreiber, Shaul; Bloch, Miki; Adelson, Miriam

doi:10.1016/j.euroneuro.2012.04.002

Cited by 16 publications

(8 citation statements)

References 29 publications

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“…In terms of symptom assessments, most studies used the Dissociative Experiences Scale (DES) (Carlson et al, 1993) or its subscale (i.e., DES-Taxon; DES-T) (Waller & Ross, 1997) to assess dissociation ( n = 13) (Dorahy et al, 2013; Dorrepaal et al, 2012; Ford et al, 2015; Ford et al, 2017; Hyland et al, 2018; Longo et al, 2019; Peles et al, 2012, 2014; Powell, 1996; Sachsse et al, 2006; Tian et al, 2020; Van Dijke et al, 2015; Zucker et al, 2006). Most studies used the International Trauma Questionnaire (ITQ) (Cloitre et al, 2018) ( n = 11) or the Structured Interview for Disorders of Extreme Stress (SIDES) (Pelcovitz et al, 1997) ( n = 6) to assess CPTSD symptoms; only nine studies used other methods (e.g., clinical assessment, the Stress Reactions Checklist for Disorders of Extreme Stress, the C-PTSD Interview Scale) to assess CPTSD symptoms (Dorahy et al, 2013; Ford et al, 2015, 2017; Haselgruber et al, 2020; Longo et al, 2019; Powell, 1996; Powers et al, 2017; Sachsse et al, 2006; Shin et al, 2021).…”

Section: Resultsmentioning

confidence: 99%

“…About one-third of the included studies ( n = 10) compared participants with and without CPTSD/DESNOS on their levels of dissociation. These studies reported that participants with CPTSD/DESNOS scored significantly higher on a dissociation measure than those without CPTSD/DESNOS (Bryant et al, 2021; Hyland et al, 2018, 2020; Longo et al, 2019; Møller et al, 2021; Murphy et al, 2021; Peles et al, 2012; Powell, 1996; Powers et al, 2017; Zucker et al, 2006) (the sample size and statistical results of each study are reported in Table 1). In particular, nine studies directly compared participants with CPTSD (or PTSD plus DESNOS) and those with PTSD alone; eight of them (Hyland et al, 2018, 2020; Longo et al, 2019; Murphy et al, 2021; Peles et al, 2012; Powell, 1996; Powers et al, 2017; Zucker et al, 2006) reported that participants with CPTSD/DESNOS had significantly higher dissociation scores than those with PTSD alone; and only one (Bryant et al, 2021) reported nonsignificant differences between complex PTSD and PTSD alone in the dissociation scores.…”

Section: Resultsmentioning

confidence: 99%

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The Relationship Between Dissociation and Complex Post-Traumatic Stress Disorder: A Scoping Review

Fung

Chien

Lam

et al. 2022

Trauma, Violence, & Abuse

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Complex post-traumatic stress disorder (CPTSD) has recently been recognized as an official psychiatric diagnosis in ICD-11, after years of research and advocacy in the field. It has been suggested that dissociative symptoms are a major feature of CPTSD. This scoping review aimed to summarize the existing knowledge base on the relationship between dissociation and CPTSD, and to identify relevant research gaps. We searched the two largest and most widely used academic databases (i.e., the Web of Science and Scopus databases) and the ProQuest database and identified original studies published in English relevant to our research questions, namely: (1) Would CPTSD be associated with dissociative symptoms? 2) How common are dissociative symptoms among people with CPTSD? (3) What are the correlates of dissociative symptoms among people with CPTSD? In all, 26 studies were included. We found 10 studies which reported that people with CPTSD scored significantly higher on a dissociation measure than those without CPTSD, and 11 studies reported a positive correlation between CPTSD symptoms and psychoform/somatoform dissociation scores. While very few studies reported the prevalence and correlates of dissociative symptoms among people with CPTSD, there may be a considerable subgroup of people with CPTSD who have clinically significant levels of dissociative symptoms (e.g., 28.6–76.9%). Dissociation may also be associated with other comorbidities (e.g., DSM-IV Axis II features, shame, somatic symptoms) in people with CPTSD. We recommend that more studies are needed to investigate the prevalence of dissociative symptoms among people with CPTSD and examine how these symptoms are associated with other comorbid conditions and clinical needs in this vulnerable group.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

The Relationship Between Dissociation and Complex Post-Traumatic Stress Disorder: A Scoping Review

Fung

Chien

Lam

et al. 2022

Trauma, Violence, & Abuse

View full text Add to dashboard Cite

show abstract

“…Another mechanism could be acquired as the result of life events which occurred before heroin was first taken. It has been shown that attention deficit hyperactivity disorder (ADHD), history of trauma, sexual abuse and conduct disorders are highly prevalent in patients entering MMT [47][48][49]. These factors have been shown to correlate with DNA methylation modifications, which may be associated with susceptibility to or a consequence of drug abuse, in peripheral blood cells [50][51][52][53].…”

Section: Discussionmentioning

confidence: 99%

Variability of Response to Methadone: Genome-Wide DNA Methylation Analysis in Two Independent Cohorts

et al. 2016

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“…11 In addition, many mothers have concurrent psychiatric diagnoses and are prescribed psychiatric medications of which breastfeeding safety is unknown. [12][13][14] Histories of trauma and complex social circumstances compound the challenges of breastfeeding and pumping. 13 Prolonged hospitalizations for NAS treatment, maternal-infant separation, and inherent infant feeding problems related to NAS can exacerbate the problem.…”

Section: Introductionmentioning

confidence: 99%

“…[12][13][14] Histories of trauma and complex social circumstances compound the challenges of breastfeeding and pumping. 13 Prolonged hospitalizations for NAS treatment, maternal-infant separation, and inherent infant feeding problems related to NAS can exacerbate the problem. 10 Medical providers' knowledge gap, apprehension, and inconsistent communication regarding the safety of breastfeeding can further deter mothers.…”

Section: Introductionmentioning

confidence: 99%

Revision of Breastfeeding Guidelines in the Setting of Maternal Opioid Use Disorder

et al. 2015

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Breastfeeding is recommended for women with opioid use disorder who are treated with methadone or buprenorphine. Infants with neonatal abstinence syndrome (NAS) secondary to in-utero opioid exposure have unique challenges related to breastfeeding but also have significant benefits including improved NAS symptoms with a decreased need for pharmacotherapy. Poor understanding of substance use disorder and treatment, lack of evidence-based recommendations, and vague guidelines from national academies create controversy about breastfeeding eligibility for these women. Defining breastfeeding guidelines is often difficult, particularly in large institutions with multiple providers caring for the mother-infant dyad. Based on the available evidence and review of our institutional data, we revised our breastfeeding guidelines for mothers with opioid use disorder. The aims of our new guidelines are (a) to safely promote breastfeeding in all mothers with opioid use disorder who are in recovery, (b) to improve NAS outcomes through use of breastfeeding as a key nonpharmacologic treatment modality, and (c) to improve staff communication and consistency on the subject of breastfeeding in this patient population.

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Psychiatric comorbidity of patients on methadone maintenance treatment with a history of sexual abuse

Cited by 16 publications

References 29 publications

The Relationship Between Dissociation and Complex Post-Traumatic Stress Disorder: A Scoping Review

The Relationship Between Dissociation and Complex Post-Traumatic Stress Disorder: A Scoping Review

Variability of Response to Methadone: Genome-Wide DNA Methylation Analysis in Two Independent Cohorts

Revision of Breastfeeding Guidelines in the Setting of Maternal Opioid Use Disorder

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