Psychiatric Complications of Dementia

Bhat, Ravi; Rockwood, Kenneth

doi:10.1177/070674371105600703

Cited by 6 publications

(5 citation statements)

References 125 publications

(181 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Additional analysis showed that the association of ideation with dementia, if any, rested on a group of persons with lower levels of severity, probably during the initial stages of the dementia, as reported by others (Seyfried et al ., ). Because psychiatric complications are common in persons with dementia (Bhat and Rockwood, ) and we lack longitudinal data to disentangle the order of sequence between dementia and further development of depression, anxiety and symptoms of psychosis, we cannot rule out that those psychiatric conditions are in between dementia and suicide ideation. If that were the case, adjustment for depression and anxiety are not recommended and our crude PR would be a better estimate for the impact of dementia on suicide ideation.…”

Section: Discussionmentioning

confidence: 99%

Suicide ideation, dementia and mental disorders among a community sample of older people in Mexico

Borges

Acosta

Sosa

2014

Int J Geriatr Psychiatry

View full text Add to dashboard Cite

Dementia plays a minor role on suicide ideation after the other aforementioned variables were taken into account and its effect, if any, could be concentrated among those elders with lower severity scores of dementia. These results show the great challenges that Mexico faces in providing services for the older people with suicidality. As the population in the country ages, suicidality will constitute an additional challenge to the healthcare system.

show abstract

Section: Discussionmentioning

confidence: 99%

Suicide ideation, dementia and mental disorders among a community sample of older people in Mexico

Borges

Acosta

Sosa

2014

Int J Geriatr Psychiatry

View full text Add to dashboard Cite

show abstract

“…Delusional symptoms are frequently linked to schizophrenic psychoses but are also observed in neurodegenerative diseases. 9 It has been suggested that the dysfunction of dopaminergic neurons projecting to the striatum contributes to delusion formation in patients with schizophrenia 10 ; however, other hypotheses also have been proposed for the neurobiological basis of delusions with schizophrenia. Delusions also have been linked to frontal cortex dysfunction causing deficits in cognitive control or executive functions.…”

Section: Introductionmentioning

confidence: 99%

Clinicopathological Study of Patients With C9ORF72-Associated Frontotemporal Dementia Presenting With Delusions

Shinagawa

Naasan

Karydas

et al. 2014

J Geriatr Psychiatry Neurol

View full text Add to dashboard Cite

Background Several clinical studies point to a high prevalence of psychotic symptoms in frontotemporal dementia associated with C9ORF72 mutations, but clinicopathological studies addressing the association between C9ORF72 mutations and delusions are lacking. Method Seventeen patients with pathologically proven frontotemporal lobar degeneration (FTLD) associated with C9ORF72 mutations were identified from Neurodegenerative Disease Brain Bank. Of the 17 cases with C9ORF72 mutation, 4 exhibited well-defined delusions. The clinical history, neurological examination, neuropsychological testing, neuroimaging analysis, and postmortem assessment of the patients with delusions were evaluated and compared with the other cases. Result The content of the delusions was mixed including persecution, infidelity, and grandiosity. All cases showed parkinsonism; voxel-based morphometry analysis showed greater precuneus atrophy in patients with delusions than those without delusions. All 4 had unclassifiable FTLD with TAR DNA-binding protein inclusions, with characteristics of both type A and type B. Three cases had additional τ pathology and another had α-synuclein pathology. Conclusion C9ORF72 carriers with well-defined delusions likely associated with additional pathologies and parietal atrophy in neuroimaging. Patients presenting with middle-aged onset of delusions should be screened for C9ORF72 mutations, especially if family history and parkinsonism are present.

show abstract

“…The types and severity of psychiatric symptoms may vary throughout the course of dementia. Morbidity in patients leads to poorer quality of life, thus increasing the caregivers' burden [27].…”

Section: Discussionmentioning

confidence: 99%

Distribution of neuropsychiatric profiles and comorbid diseases in dementia subtypes

Bülbül,

Karşıdağ,

Çınar

et al. 2024

The European Research Journal

View full text Add to dashboard Cite

Objectives: Alzheimer’s disease (AH) is the most prevalent cause of dementia, followed closely by vascular dementia. Mixed vascular-Alzheimer’s dementia (MVAD) is more evident in individuals aged 80 and above. Frontotemporal dementia (FTD) is the second most common cause of early-onset dementia after AH. Vascular risk factors play important role in the pathogenesis of dementia syndromes. Behavioral and psychological symptoms represent a significant portion of the non-cognitive manifestations in dementia patients. This study aimed to evaluate the distribution of chronic diseases, behavioral disorders, psychiatric findings, and medication use in patients followed with different dementia diagnoses. Methods: Prevalance of chronic diseases, behavioral disorders, psychiatric findings as well as the usage of antidepressant and antipsychotic medications among patients followed up in dementia outpatient clinics with the diagnosis of AD, mild cognitive impairment (MCI), vascular dementia (VaD), FTD, and MVAD were investigated. Neuropsychiatric inventory (NPI) was applied to the patients. Results: Four hundred and fifty-five patients were accepted in the study. The patients were distributed as follows: AD (n=303, female/male: 187/115, age = 78±8 years), MCI (n=53, female/male: 31/22, age = 69±10 years), VaD (n=31, female/male: 18/13, age = 68±9 years), FTD (n=32, female/male: 17/15, age = 68±9 years), and MVAD (n=36, female/male: 16/20, age = 76±10 years). Both AD and MVAD groups were significantly older than the other groups (F = 23.2, P<0.0001). The ratio of comorbid chronic diseases was 80% in the AD group, 72% in the MCI group, 91% in the VaD group, 59% in the FTD group, and 93% in the MVAD group. In the whole group, antipsychotic drug use was 27.5% and antidepressant drug use was 28.9%. The mean NPI score was 32.9±28 in antipsychotic users and 16±19 in non-users (P<0.0001). The mean NPI of antidepressant users was 17.6±19 and 21.9±25 (P=0.055) in non-users. Conclusion: There is a comorbid chronic disease burden in all dementia subtypes, although at varying intensities, and as the chronic disease burden increases, behavioral disorders and psychotic findings increase, and accordingly, the use of antipsychotics also increases.

show abstract

Psychiatric Complications of Dementia

Cited by 6 publications

References 125 publications

Suicide ideation, dementia and mental disorders among a community sample of older people in Mexico

Suicide ideation, dementia and mental disorders among a community sample of older people in Mexico

Clinicopathological Study of Patients With C9ORF72-Associated Frontotemporal Dementia Presenting With Delusions

Distribution of neuropsychiatric profiles and comorbid diseases in dementia subtypes

Contact Info

Product

Resources

About