Psychiatric Conditions in Parkinson Disease

Buoli, Massimiliano; Caldiroli, Alice; Altamura, Alfredo Carlo

doi:10.1177/0891988715606233

Cited by 15 publications

(3 citation statements)

References 325 publications

(391 reference statements)

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“…Melancholic depression appears to be associated with significant dysregulation of the DA system (e.g., higher frequency in people with Parkinson's disease) [415]. Decreased dopaminergic function leads to psychomotor retardation which could underpin learned helplessness [416].…”

Section: Melancholiamentioning

confidence: 99%

Peripheral Markers of Depression

Nobis

Zalewski

Waszkiewicz

2020

JCM

129

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Major Depressive Disorder (MDD) is a leading cause of disability worldwide, creating a high medical and socioeconomic burden. There is a growing interest in the biological underpinnings of depression, which are reflected by altered levels of biological markers. Among others, enhanced inflammation has been reported in MDD, as reflected by increased concentrations of inflammatory markers—C-reactive protein, interleukin-6, tumor necrosis factor-α and soluble interleukin-2 receptor. Oxidative and nitrosative stress also plays a role in the pathophysiology of MDD. Notably, increased levels of lipid peroxidation markers are characteristic of MDD. Dysregulation of the stress axis, along with increased cortisol levels, have also been reported in MDD. Alterations in growth factors, with a significant decrease in brain-derived neurotrophic factor and an increase in fibroblast growth factor-2 and insulin-like growth factor-1 concentrations have also been found in MDD. Finally, kynurenine metabolites, increased glutamate and decreased total cholesterol also hold promise as reliable biomarkers for MDD. Research in the field of MDD biomarkers is hindered by insufficient understanding of MDD etiopathogenesis, substantial heterogeneity of the disorder, common co-morbidities and low specificity of biomarkers. The construction of biomarker panels and their evaluation with use of new technologies may have the potential to overcome the above mentioned obstacles.

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Section: Melancholiamentioning

confidence: 99%

Peripheral Markers of Depression

Nobis

Zalewski

Waszkiewicz

2020

JCM

129

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“…For example, the gradient and length of slope can play an important role in determining velocity of river flow, soil wetness, and the distribution of wetlands. This can play an important role in the control of DOC, dissolved organic nitrogen, and nitrate in stream waters (Ogawa et al 2006) and set the possible range for range DOC concentrations in lakes (Sobek et al 2007). Higher-velocity water also has higher concentrations of dissolved oxygen, due to turbulence at the surface.…”

Section: Topographymentioning

confidence: 99%

Good Ambient Water Quality

Warner

Chapman

Dickens

2020

Encyclopedia of the UN Sustainable Development Goals

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Water quality is the suitability of water to sustain various uses or processes (Meybeck et al. 1996), and ambient is "relating to the immediate surroundings of something" (ambient, 2018). Ambient water quality refers to natural, untreated water in rivers, lakes, and groundwaters. Good ambient water quality is the positive conclusion of a water quality assessment of these waters affected by a combination of natural influences such as climate and geology and also anthropogenic activities, such as wastewater outflows and agricultural runoff. Ambient water quality is defined as "good" if the assessment concludes the water is not harmful to either the aquatic ecosystem or human health.

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“…Parkinson’s disease (PD) is the second most common neurodegenerative disorder, occurring with 0.3–1% prevalence in the 60–80-year range. It is characterized, in the most common form of the pathogenesis, by dopaminergic neurodegeneration of the nigrostriatal pathway, resulting in both motor and non-motor symptoms [ 1 , 2 , 3 , 4 ]. Deep Brain Stimulation of the Subthalamic Nucleus (STN-DBS) proved to be highly effective in treating many of PD’s motor symptoms and often allows medication reduction [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Psychiatric Symptoms in Parkinson’s Disease Patients before and One Year after Subthalamic Nucleus Deep Brain Stimulation Therapy: Role of Lead Positioning and Not of Total Electrical Energy Delivered

Somma

Esposito

Scala

et al. 2022

JPM

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Parkinson’s disease (PD) patients may experience neuropsychiatric symptoms, including depression, anxiety, sleep disturbances, psychosis, as well as behavioral and cognitive symptoms during all the different stages of the illness. Deep Brain Stimulation (DBS) therapy has proven to be successful in controlling the motor symptoms of PD and its possible correlation with the occurrence or worsening of neuropsychiatric symptoms has been reported. We aimed to assess the neuropsychiatric symptoms of 14 PD patients before and after one year of Subthalamic Nucleus (STN)-DBS and to correlate the possible changes to the lead placement and to the total electrical energy delivered. We assessed PD motor symptoms, depression, anxiety, apathy, impulsivity, and suicidality using clinician- and/or self-administered rating scales and correlated the results to the lead position using the Medtronic SuretuneTM software and to the total electrical energy delivered (TEED). At the 12-month follow-up, the patients showed a significant improvement in PD symptoms on the UPDRS (Unified Parkinson’s Disease Rating Scale) (−38.5%; p < 0.001) and in anxiety on the Hamilton Anxiety Rating Scale (HAM-A) (−29%; p = 0.041), with the most significant reduction in the physiological anxiety subscore (−36.26%; p < 0.001). A mild worsening of impulsivity was detected on the Barratt Impulsiveness Scale (BIS-11) (+9%; p = 0.048), with the greatest increase in the attentional impulsiveness subscore (+13.60%; p = 0.050). No statistically significant differences were found for the other scales. No correlation was found between TEED and scales’ scores, while the positioning of the stimulating electrodes in the different portions of the STN was shown to considerably influence the outcome, with more anterior and/or medial lead position negatively influencing psychiatric symptoms.

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Psychiatric Conditions in Parkinson Disease

Cited by 15 publications

References 325 publications

Peripheral Markers of Depression

Peripheral Markers of Depression

Good Ambient Water Quality

Psychiatric Symptoms in Parkinson’s Disease Patients before and One Year after Subthalamic Nucleus Deep Brain Stimulation Therapy: Role of Lead Positioning and Not of Total Electrical Energy Delivered

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