Psychiatric disorders and pruritus

Lee, Helen Gin; Stull, Carolyn; Yosipovitch, Gil

doi:10.1016/j.clindermatol.2017.01.008

Cited by 42 publications

(40 citation statements)

References 65 publications

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“…Although the exact pathophysiology of pruritus is not fully elucidated, the central neural mechanisms of itch have been suggested to be mediated by neuropeptides, especially endogenous opioids, and histamine [17,18]. Gupta et al described the association between depression and elevated levels of corticotropin releasing factor, leading to increased central opiate levels and heightened perception of itch sensation [19].…”

Section: Discussionmentioning

confidence: 99%

Racial and Gender Differences in the Presentation of Pruritus

et al. 2019

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Background: Pruritus is a common disease symptom with a variety of etiologies known to reduce patient quality of life. We aimed to characterize the racial and gender differences in the presentation of pruritus for itch-related patient visits both within a single institution and nationally. Methods: Cross sectional study of patients ≥ 18 years old seen at Johns Hopkins Health System between 1/1/12 and 1/1/18. Results were compared to data from 2005–2011 from the National Ambulatory Medical Care Survey (NAMCS) and the National Health Ambulatory Medical Care Survey (NHAMCS). Results: Our findings indicate that itch patients at JHHS (n = 18,753) were more likely to be black compared to white patients (37% vs. 19%, p < 0.01) when compared to patients without itch—a trend also noted nationally based on data from NAMCS/NHAMCS (26% vs. 21%, p = 0.05). Black itch patients are also more likely to be diagnosed with prurigo nodularis (OR 2.37, p < 0.0001), lichen planus (OR 1.22, p < 0.0001), and atopic dermatitis OR 1.51, p < 0.0001). Female itch patients are more likely to be diagnosed with autoimmune (OR 1.66, p < 0.0001) and psychiatric comorbidities (OR 1.2–1.8, p < 0.0001) than male itch patients. When compared to black itch patients nationally, white itch patients were more likely to visit a dermatologist (29% vs. 18%, p = 0.028). Our data can identify associated conditions and demographic differences but are unable to support a causal relationship. Conclusions: Black and female patients are more likely to present with pruritus, a symptom associated with comorbidities such as prurigo nodularis, lichen planus, atopic dermatitis, and psychiatric conditions.

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Section: Discussionmentioning

confidence: 99%

Racial and Gender Differences in the Presentation of Pruritus

et al. 2019

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“…PN has been significantly associated with depression, anxiety, and dissociative experiences, all of which can cause psychogenic pruritus [1,[53][54][55][56][57][58]. This psychogenic pruritus is then thought to lead to PN.…”

Section: Psychiatricmentioning

confidence: 99%

Diagnostic Workup and Evaluation of Patients with Prurigo Nodularis

et al. 2019

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Prurigo nodularis (PN) is a chronic inflammatory skin disease characterized oftentimes by symmetrically distributed, severely pruritic nodules. Currently, the pathophysiology of PN remains to be fully elucidated, but emerging evidence suggests that neuroimmune alterations play principal roles in the pathogenesis of PN. There are several associated etiologic factors thought to be associated with PN, including dermatoses, systemic, infectious, psychiatric, and neurologic conditions. We conducted a systematic literature review to evaluate the clinical presentation, diagnosis, and etiologic factors of PN. In this review, we discuss common differential diagnoses of PN and recommend an evidence-based, standardized diagnostic evaluation for those with suspected PN.

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“…Besides dermatological etiologies, systemic diseases, neurological disorders and psychosomatic/psychiatric diseases are attributed to lead to pruritus (2,11). Several systemic diseases including iron deficiency anemia, hepatobiliary diseases, polycythemia vera, neoplasms and endocrine disorders have been reported to be especially associated with the chronic form of pruritus in the literature (12).…”

Section: Discussionmentioning

confidence: 99%

Factors Affecting the Etiology of Intractable Pruritus in Hospitalized Patients Without Primary Skin Lesions

Akdoğan¹,

Uysal²,

Öktem³

et al. 2019

Istanbul Med J

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Amaç: Kaşıntı sık görülen bir belirti olup dermatolojik, sistemik, nörolojik, psikojenik, mikst ve bilinmeyen sebepleri vardır. Bu çalışmanın amacı sekonder deri lezyonları (SDL) ile prezente olan, dirençli kaşıntı nedeniyle hastanede yatan hastalarda kaşıntı etiyolojisini (KET) bulmak ve KET'i etkileyen faktörleri değerlendirmektedir. Yöntemler: Retrospektif olarak SDL olan 95 hasta (erkek/ kadın: 47/48) çalışmaya alındı. Demografik ve klinik özellikler, tanısal işlemler ve tedavi ajanları kaydedildi. KET dermatolojik ve dermatoloji dışı sebepler olarak tanımlandı. Bulgular: Çalışmamızda ortalama (aralık) yaş 61 (11-91) yıl ve hastalık süresi 2 (0,06-120) aydı. Kaşıntı %78 hastada dermatolojik, %22 hastada dermatoloji dışı sebeplerle ilişkili bulundu. Tek değişkenli analiz yaş, ortalama hastalık süresi, akut veya kronik seyir, 3 aydan uzun süre sürekli ilaç kullanımı, kaşıntıya yol açabilecek ilaç kullanımı, eşlik eden sistemik hastalık, polifarmasi, böbrek fonksiyon testleri ve uyku bozukluğu varlığı ile altta yatan dermatolojik sebebe bağlı kaşıntısı (DSK) olan ve olmayan hastalarda ilişki gösterdi (sırasıyla p=0,

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Psychiatric disorders and pruritus

Cited by 42 publications

References 65 publications

Racial and Gender Differences in the Presentation of Pruritus

Racial and Gender Differences in the Presentation of Pruritus

Diagnostic Workup and Evaluation of Patients with Prurigo Nodularis

Factors Affecting the Etiology of Intractable Pruritus in Hospitalized Patients Without Primary Skin Lesions

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