Psychiatric disorders in temporal lobe epilepsy: An overview from a tertiary service in Brazil

Abstract

TLE is related to a high frequency of psychiatric disorders, such as anxiety and depression, which are usually underdiagnosed and undertreated. Damage to the left mesial temporal lobe, seen in LMTS, seems to be an important pathogenic lesion linked to a broad range of psychopathological features in TLE, mainly anxiety disorders. The present study prompts discussion on the recognition of the common psychiatric disorders in TLE, especially on the Brazilian setting.

Psychosis and temporal lobe epilepsy-role of electroconvulsive therapy

“…In such cases, video EEG-telemetry and MRI were recommended if routine EEG and CT scan remain normal. A Brazilian study4 found that patients with TLE had a high frequency of lifetime psychiatric disorders (70%), the most frequent being mood disorders (49.3%). Structured psychiatric interviews were emphasised by Bragatti JA et al 5 in a study on Southern Brazilian population.…”

Comorbidity

“…Patients with epilepsy are reported to be at a two-to sixfold higher risk to manifest BD (Ottman et al 2011 ;Ettinger et al 2005 ;de Oliveira et al 2010 ;Clarke et al 2012 ;Adelow et al 2012 ;Mula et al 2009 ) although there are reports suggesting that BD in epileptic patients has a rate similar to that seen in the general population (Harden and Goldstein 2002 ;Mula et al 2008b ).…”

Blockade of p75 Neurotrophin Receptor Reverses Irritability and Anxiety-Related Behaviors in a Rat Model of Status Epilepticus

“…Studies have shown that the prevalence of psychiatric disorders in patients with epilepsy is more frequent than that in general population [1,2] . More than one in four epileptic patients have experienced psychological problems, E which might need treatment, and more than 10% of patients in psychiatric hospitals are diagnosed with epilepsy [3] . Seizure is related with neurological and behavioral problems such as anxiety, memory impairment, psychosis, and cognitive dysfunction, which affect the quality of life of patients [4][5][6] .…”