“…Another concurrent study based on a separate database, the Nationwide Inpatient Sample (NIS), demonstrated that a preoperative diagnosis of depression was linked to a higher risk of postoperative medical complications including anemia, infection, and pulmonary embolism [OR for anemia 1.14 with CI 1.09-1.17, P < .001; OR for infection 1.33 with CI 1.21-1.41, P = .012; OR for PE 1.20 with CI 1.14-1.25, P = .005; Table 1] [15]. These findings were again corroborated by a single institution's retrospective review of approximately 2000 patients, where a preoperative diagnosis of depression or anxiety was independently associated with a statistically significant increase in the rate of postoperative medical complications after hip and knee arthroplasty from 15.5% in the cohort with no mental health disorders to 29% in the patients with depression or anxiety [P < .001, showed that patients with a diagnosis of depression, bipolar disorder, or schizophrenia had a twofold increase in the likelihood of knee extensor mechanism rupture, periprosthetic fracture, prosthetic join infection, and need for revision arthroplasty at minimum of 2-year follow-up [OR for extensor mechanism rupture 2.18 with CI 1.95-2.42, P < .001; OR for periprosthetic fracture 2.20 with CI 1.96-2.47, P < .001; OR for prosthetic joint infection 2.08 with CI 1.98-2.17, P < .001; OR for revision arthroplasty 2.01 with CI 1.88-2.15, P < .001; Table 1] [19].…”