Psychiatric Disturbances in Turner’s Syndrome

Christodorescu, D; Collino, Sebastiano; R, Zellingher; Tăutu, C

doi:10.1159/000278598

Cited by 2 publications

(1 citation statement)

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“…Regarding symptom severity, two of these studies (Money & Mittenthal, 1970;Nielsen et al, 1977) reported an average severity of depressive illness, while the remaining three were not able to comment on severity (Bender et al, 1995;Nielsen & Stradiot, 1987;Sabbath et al, 1961). The remaining nine articles (26% of the surveyed literature) are case reports or case series that relied only on expert opinion to make the determination of depression (Quality of Data Level 4), thus by design they do not have a control group or present data that are comparable to other populations (Christodorescu, Collino, Zellingher, & Tăutu, 1970;Dickens, 1970;Fishbain & Vilasuso, 1981;Larocca, 1985;Nielsen, 1970;Nielsen & Thomsen, 1968;Panzer & Tandon, 1991;Pitts & Guze, 1963;Shea & Wolfman, 2017). Table 2 summarizes the studies discussed above, categorized by method of depression evaluation and presence/ absence of control group.…”

Section: Resultsmentioning

confidence: 99%

Depression in Turner Syndrome: A Systematic Review

et al. 2019

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Turner syndrome (TS) is a genetic condition characterized by partial or complete monosomy X. Alterations in hormonal function, height, and peer relationships, among other features and correlates of TS, appear to be risks for depressive illness. In order to summarize what is known about depression in Turner syndrome, with the aim of determining if individuals with TS are at increased risk for depression, a literature search and analysis was conducted. In total, 69 studies were identified and 35 met criteria of being peer-reviewed English language articles that collected original data on the experience of depression in individuals with TS. Most studies used patient or parent questionnaires to evaluate depressive symptoms. These studies, a majority of which examined adults and half that examined adolescents, found that individuals with TS experienced more frequent and severe depressive symptoms than individuals without TS diagnoses. Articles studying children with TS did not demonstrate a difference in their depressive experience compared to individuals without TS. Three articles used clinician administered scales, such as the Structured Clinical Interview for DSM-IV; all diagnosed depression in those with TS at higher rates than others. Five studies relied on expert opinion to evaluate depression. The remaining eight articles were case reports or case series that relied on expert opinion. From these data, we conclude that adolescents and adults with TS are at risk for depression and adulthood appears to be the period of highest risk. Studies in the last 12 years show consistently more severe depressive symptoms in individuals with TS than in previous years. Implications, risk factors, and recommendations for future research are discussed.

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