Psychiatric manifestations of hyponatremia

Gehi, Mohan; Rosenthal, Renate H.; Fizette, Norman B.; Crowe, Lee R.; Webb, William L.

doi:10.1016/s0033-3182(81)73103-7

Cited by 27 publications

(11 citation statements)

References 13 publications

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“…The hypothesis that cognitive decline in persons with TBI may be attributable to hyponatremia is a logical extension ofreports that hyponatremia is found in up to one-third of patients following severe TBI [2] and that patients with absolute hyponatremia (< 128 mEq/L) may display depression of sensorium [3,4,5,71. This study investigated the incidence of hyponatremia in a population of rehabilitation inpatients with non-penetrating TBI and the relationship between cognitive decline and relative or absolute hyponatremia.…”

Section: Discussionmentioning

confidence: 99%

“…While the relationship between hyponatremia and secondary cognitive impairment has not been studied extensively in TBI patients, it has been the subject of research with hospitalized [4] and schizophrenic patients [ 5 ] . Gehi et al.…”

Section: Introductionmentioning

confidence: 99%

“…Gehi et al. [4] compared Cognitive Capacity Screening Examination scores for groups of medical patients with and without hyponatremia. Initially lower cognitive scores in the hyponatremic patients improved with correction of the hyponatremia.…”

Section: Introductionmentioning

confidence: 99%

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Hyponatremia-associated cognitive impairment in traumatic brain injury

et al. 1993

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The case of a traumatic brain injury (TBI) patient with dramatic cognitive deterioration in the absence of medical aetiology other than simultaneous decline in serum sodium led to an investigation of the association between declines in sodium levels and cognitive status. In a population of 50 persons undergoing TBI rehabilitation, 12 (24%) had relative (3 mEq/L) decreases in serum sodium while five (10%) experienced absolute hyponatremia (136 mEq/L). Correlation with cognitive status was significant when the absolute hyponatremia group was compared with those whose sodium levels remained above 136 mEq/L. A case-matched study of the relative hyponatremia group yielded no significant association between sodium-level decreases and cognitive status. These data support previous conclusions indicating wide variation in individual responses to changes in serum sodium. The threshold for significant effects of hyponatremia may be higher in patients with TBI than in populations studied previously.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Hyponatremia-associated cognitive impairment in traumatic brain injury

et al. 1993

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“…Hypoxemia or hypercarbia related to decreased respiratory drive or poor airway protection must be detected and treated appropriately. Metabolic disturbances, including acidosis, hyponatremia, hypoglycemia, hypercalcemia, hyperamylasemia, hyperammonemia, or hepatic or renal insufficiency may contribute to behavioral changes in critically ill patients [4][5][6][7][8]. Infection is also a frequent trigger of delirium in hospitalized and critically ill patients [4].…”

Section: Indications For Sedationmentioning

confidence: 99%

“…Metabolic disturbances, including acidosis, hyponatremia, hypoglycemia, hypercalcemia, hyperamylasemia, hyperammonemia, or hepatic or renal insufficiency may contribute to behavioral changes in critically ill patients [4][5][6][7][8]. Infection is also a frequent trigger of delirium in hospitalized and critically ill patients [4]. Cardiac ischemia, hypotension, and associated cerebral hypoperfusion may also contribute to mental status changes, and must be ruled out as a cause of delirium in critically ill neurologic patients [9].…”

Section: Indications For Sedationmentioning

confidence: 99%