Psychiatric Manifestations of Withdrawal Following Domperidone Used as a Galactagogue

Majdinasab, Elleana J; Haque, Sarah; Stark, Amy L.; Krutsch, Kaytlin; Hale, Thomas W.

doi:10.1089/bfm.2022.0190

Cited by 5 publications

(1 citation statement)

References 16 publications

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“…Domperidone is widely used as an antiemetic and motility agent that has been used off-label to improve lactation during breastfeeding [ 18 ]. Recent reports highlight safety concerns of domperidone including potential withdrawal concerns and heart problems [ 19 , 20 ]. Analysis of self-reported reasons for use among participants confirmed that domperidone was being widely used off-label at 3 months in an attempt to increase milk supply– sometimes unsuccessfully, since many NBFW at the 3-month time point reported using domperidone to combat lactation disorders prior to stopping breastfeeding.…”

Section: Discussionmentioning

confidence: 99%

The use of prescription medications and non-prescription medications during lactation in a prospective Canadian cohort study

Soliman,

Yakandawala,

Leong

et al. 2024

Int Breastfeed J

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Background A lack of safety data on postpartum medication use presents a potential barrier to breastfeeding and may result in infant exposure to medications in breastmilk. The type and extent of medication use by lactating women requires investigation. Methods Data were collected from the CHILD Cohort Study which enrolled pregnant women across Canada between 2008 and 2012. Participants completed questionnaires regarding medications and non-prescription medications used and breastfeeding status at 3, 6 and 12 months postpartum. Medications, along with self-reported reasons for medication use, were categorized by ontologies [hierarchical controlled vocabulary] as part of a large-scale curation effort to enable more robust investigations of reasons for medication use. Results A total of 3542 mother-infant dyads were recruited to the CHILD study. Breastfeeding rates were 87.4%, 75.3%, 45.5% at 3, 6 and 12 months respectively. About 40% of women who were breastfeeding at 3 months used at least one prescription medication during the first three months postpartum; this proportion decreased over time to 29.5% % at 6 months and 32.8% at 12 months. The most commonly used prescription medication by breastfeeding women was domperidone at 3 months (9.0%, n = 229/2540) and 6 months (5.6%, n = 109/1948), and norethisterone at 12 months (4.1%, n = 48/1180). The vast majority of domperidone use by breastfeeding women (97.3%) was for lactation purposes which is off-label (signifying unapproved use of an approved medication). Non-prescription medications were more often used among breastfeeding than non-breastfeeding women (67.6% versus 48.9% at 3 months, p < 0.0001), The most commonly used non-prescription medications were multivitamins and Vitamin D at 3, 6 and 12 months postpartum. Conclusions In Canada, medication use is common postpartum; 40% of breastfeeding women use prescription medications in the first 3 months postpartum. A diverse range of medications were used, with many women taking more than one prescription and non-prescription medicines. The most commonly used prescription medication by breastfeeding women were domperidone for off-label lactation support, signalling a need for more data on the efficacy of domperidone for this indication. This data should inform research priorities and communication strategies developed to optimize care during lactation.

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Section: Discussionmentioning

confidence: 99%