Islamic spiritual healing is a complementary technique in traditional medicine that is very popular in Muslim-majority countries, in terms of its affordability, availability, and accessibility. However, lack of studies investigating feedback of the treatment despite its popularity and practices worldwide has left a void in the evidence of Islamic spiritual care aspect of conventional health care system. A retrospective study was conducted to determine the prevalence and patient feedback of spiritual healing in the main Islamic healing center in Brunei; 1,378 data points were extracted from the center's database and used for analysis. The results showed that 26 -32% of patients reported positive feedback after treatment, particularly significant for those with spiritual disturbances, which accounts up to 24% of total cases. Patients with heart disease, emotional issues, and sleeping difficulties were significantly associated and more likely to have spiritual disturbance symptoms. Positive feedback was significantly higher in female patients and those aged above 50. Interestingly, there was significant association between spiritual disturbances and heart disease, a major cause of mortality worldwide. Future studies should therefore explore the effects of Islamic spiritual healing into heart disease, particularly on the biochemical and physiological changes, to formulate a holistic approach to treatment.