Psychiatric morbidity among patients attending the post-COVID clinic and its association with hematological inflammatory markers

Swami, Mukesh Kumar; Mahal, Pankaj; Arora, Isha Kaur; Mishra, Vikash Chandra; panda, Tushar Kanta; Nebhinani, Naresh; Kumar, Deepak; Banerjee, Mithu; Garg, Mahendra Kumar

doi:10.1016/j.ajp.2022.103293

Cited by 3 publications

(3 citation statements)

References 9 publications

(11 reference statements)

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“…This may because that most COVID-19 survivors recovered from psychiatric symptoms, thereby inflammation is not a significant contributor to psychiatric morbidity in patients with COVID-19 in the long term. ( Swami et al, 2022 )…”

Section: Discussionmentioning

confidence: 99%

Long term neuropsychiatric consequences in COVID-19 survivors: Cognitive impairment and inflammatory underpinnings fifteen months after discharge

He¹,

Yuan²,

Wen³

et al. 2023

Asian Journal of Psychiatry

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Section: Discussionmentioning

confidence: 99%

Long term neuropsychiatric consequences in COVID-19 survivors: Cognitive impairment and inflammatory underpinnings fifteen months after discharge

He¹,

Yuan²,

Wen³

et al. 2023

Asian Journal of Psychiatry

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“…The authors suggest that psychological factors should be taken into consideration and analyzed while determining associations between hematological inflammatory indexes and psychiatric disorders; this inflammation may represent the severity of the condition, this indirectly affects depression and anxiety. ( 24) 24 Our main finding was the presence of mild anxiety (54.9%) and mild depression (41.2%), suggesting that due to the severity of these symptoms the lack of association with inflammation markers was found. In accordance with Swami, et al (2022), the authors reported no-association of inflammatory biomarkers with depression, anxiety and stress scores in the subjects post-COVID-19 condition 24 .…”

Section: Discussionmentioning

confidence: 76%

“…( 24) 24 Our main finding was the presence of mild anxiety (54.9%) and mild depression (41.2%), suggesting that due to the severity of these symptoms the lack of association with inflammation markers was found. In accordance with Swami, et al (2022), the authors reported no-association of inflammatory biomarkers with depression, anxiety and stress scores in the subjects post-COVID-19 condition 24 .…”

Section: Discussionmentioning

confidence: 84%

Neuropsychiatric symptoms of post-COVID-19 condition in Mexican healthcare personnel.

Ruiz-Ramos,

Alonso-García,

Salazar-Rifka

et al. 2023

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Objective: The aim of the present study was to identify anxiety and depression in health personnel who suffered COVID-19, and to associate them with blood inflammatory markers. Materials and methods: The design of this study was descriptive and cross-sectional. We evaluated 51 healthcare workers who survived COVID-19 disease with Hamilton scales for anxiety and depression, also we calculated inflammatory markers (systemic immune-inflammation index, SII; monocyte lymphocyte ratio, MLR; platelet lymphocyte ratio, PLR; and neutrophil lymphocyte ratio, NLR) using blood venous samples. This study was carried out from August 2021 to December 2022. Statistical analysis was performed using SPSS v. 26. Results: Our study included 51 healthcare personnel, females (n=29) and males (n=22). The mean age was 40.54 ± 11.00 years. The most frequent acute symptoms for COVID-19 presented were dysgeusia (n=20), anosmia (n=18), and headache (n=17). The most common comorbidities were overweight (n=24), obesity (n=22), and hypertension (n=11). According to the Hamilton Rating Scale for Anxiety (HARS) and Hamilton Rating Scale for Depression Rating (HRSD) we identify anxiety and depression in 72.5% (n=37) and 51% (n=26) within the health personnel, respectively. Conclusions: In our study, we observed a high frequency of anxiety and depression in healthcare workers with post COVID-19 condition. However, we did not observe an association between inflammatory markers (NLR, PLR, MLR, and SII) with anxiety and depression in health personnel post-COVID-19. We suggest follow-up assessments in healthcare personnel with post-COVID-19 condition, to evaluate if mixed emotional disorders persist. Keywords: Anxiety; Depression; Mental disorders; Inflammation; COVID-19.

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The global prevalence of depression, anxiety, and sleep disorder among patients coping with Post COVID-19 syndrome (long COVID): a systematic review and meta-analysis

Seighali,

Abdollahi,

Shafiee

et al. 2024

BMC Psychiatry

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Background Post COVID-19 syndrome, also known as "Long COVID," is a complex and multifaceted condition that affects individuals who have recovered from SARS-CoV-2 infection. This systematic review and meta-analysis aim to comprehensively assess the global prevalence of depression, anxiety, and sleep disorder in individuals coping with Post COVID-19 syndrome. Methods A rigorous search of electronic databases was conducted to identify original studies until 24 January 2023. The inclusion criteria comprised studies employing previously validated assessment tools for depression, anxiety, and sleep disorders, reporting prevalence rates, and encompassing patients of all age groups and geographical regions for subgroup analysis Random effects model was utilized for the meta-analysis. Meta-regression analysis was done. Results The pooled prevalence of depression and anxiety among patients coping with Post COVID-19 syndrome was estimated to be 23% (95% CI: 20%—26%; I2 = 99.9%) based on data from 143 studies with 7,782,124 participants and 132 studies with 9,320,687 participants, respectively. The pooled prevalence of sleep disorder among these patients, derived from 27 studies with 15,362 participants, was estimated to be 45% (95% CI: 37%—53%; I2 = 98.7%). Subgroup analyses based on geographical regions and assessment scales revealed significant variations in prevalence rates. Meta-regression analysis showed significant correlations between the prevalence and total sample size of studies, the age of participants, and the percentage of male participants. Publication bias was assessed using Doi plot visualization and the Peters test, revealing a potential source of publication bias for depression (p = 0.0085) and sleep disorder (p = 0.02). However, no evidence of publication bias was found for anxiety (p = 0.11). Conclusion This systematic review and meta-analysis demonstrate a considerable burden of mental health issues, including depression, anxiety, and sleep disorders, among individuals recovering from COVID-19. The findings emphasize the need for comprehensive mental health support and tailored interventions for patients experiencing persistent symptoms after COVID-19 recovery.

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Psychiatric morbidity among patients attending the post-COVID clinic and its association with hematological inflammatory markers

Cited by 3 publications

References 9 publications

Long term neuropsychiatric consequences in COVID-19 survivors: Cognitive impairment and inflammatory underpinnings fifteen months after discharge

Long term neuropsychiatric consequences in COVID-19 survivors: Cognitive impairment and inflammatory underpinnings fifteen months after discharge

Neuropsychiatric symptoms of post-COVID-19 condition in Mexican healthcare personnel.

The global prevalence of depression, anxiety, and sleep disorder among patients coping with Post COVID-19 syndrome (long COVID): a systematic review and meta-analysis

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