PSYCHIATRIC SYMPTOMS DUE TO VITAMIN B
            <sub>12</sub>
            DEFICIENCY WITHOUT ANAEMIA

Pw, Burvill; Jm, Jackson; Wg, Smith

doi:10.5694/j.1326-5377.1969.tb107154.x

Cited by 11 publications

(2 citation statements)

References 6 publications

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“…It is the ambiguity of symptoms that prompts us to further rule out the possibility of organic diseases. Previous studies have also illustrated that vitamin B12 deficiency can lead to psychiatric symptoms [4,9].…”

Section: Discussionmentioning

confidence: 98%

Vitamin B12 Deficiency Presenting as Psychotic Symptoms in a Psychiatry Department: A Case Report

Zheng,

Qiu,

Zhang

et al. 2023

Cureus

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Vitamin B12 deficiency is a metabolic disorder affecting the functions of hematopoietic system and nervous system. It manifests as a wide spectrum of anemia and nervous system symptoms, but psychotic symptoms are rare. We report a case of a 34-year-old man with an unbalanced diet who initially presented with psychotic symptoms. Prompt remission was achieved through vitamin B12 repletion, ultimately leading to a diagnosis of mental disorder caused by vitamin B12 deficiency. The patient provided his written informed consent to participate in this study. This case report emphasizes the importance of ruling out vitamin B12 deficiency in patients with psychotic symptoms instead of directly diagnosing schizophrenia, especially in cases where diet is unbalanced.

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Section: Discussionmentioning

confidence: 98%

Vitamin B12 Deficiency Presenting as Psychotic Symptoms in a Psychiatry Department: A Case Report

Zheng,

Qiu,

Zhang

et al. 2023

Cureus

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“…In most cases of nitrous oxide intoxication, patients present with neurological, hematological or neuropsychiatric symptoms [13]. Nevertheless, psychiatric disturbances may also be the first presenting symptoms [52] and may occur in the absence of the well-known neurological and hematologic abnormalities [38,53]. Some reports [54] suggest that psychiatric manifestations often predate the neurological symptoms, by as much as several years.…”

Section: Discussionmentioning

confidence: 99%

Does vitamin B12 deficiency explain psychiatric symptoms in recreational nitrous oxide users? A narrative review

Paulus

Wijnhoven

Maessen

et al. 2021

Clinical Toxicology

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Background Recreational use of nitrous oxide (N 2 O) is associated with many side effects, of which neurological complications are most common. Nitrous oxide abuse is also associated with psychiatric symptoms, but these have received less attention so far. Vitamin B12 deficiency may play a role in the development of these psychiatric symptoms. Aims To explore the relationship among the occurrence of recreational nitrous oxide-induced psychiatric symptoms, accompanying neurological symptoms, vitamin B12 status and choice of treatment. Methods A retrospective search for case reports was conducted across multiple databases (Pubmed, Embase, Web of Science, PsycINFO and CINAHL). Keywords included variants of "nitrous oxide", "case report" and "abuse". No restrictions to language or publication date were applied. Results The search retrieved 372 articles. A total of 25 case reports were included, representing 31 patients with psychiatric complications following nitrous oxide abuse. The most often reported symptoms were: hallucinations (n ¼ 16), delusions (n ¼ 11), and paranoia (n ¼ 11). When neurological symptoms were present, patients were treated more frequently with vitamin B12 supplementation. Conclusions This review highlights the need to recognize that psychiatric symptoms may appear in association with nitrous oxide use. Approximately half of the cases that presented with nitrous oxideinduced psychiatric complaints did not show neurological symptoms, and their vitamin B12 concentration was often within the hospital's reference range. Psychiatrists and emergency physicians should be aware of isolated psychiatric symptoms caused by recreational nitrous oxide abuse. We suggest asking all patients with new psychiatric symptoms about nitrous oxide use and protocolizing the management of nitrous oxide-induced psychiatric symptoms.

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Advancing Neuroprotective-Based Treatments for Schizophrenia

Ritsner

Lerner

2011

Handbook of Schizophrenia Spectrum Disorders, Volume III

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PSYCHIATRIC SYMPTOMS DUE TO VITAMIN B ₁₂ DEFICIENCY WITHOUT ANAEMIA

Cited by 11 publications

References 6 publications

Vitamin B12 Deficiency Presenting as Psychotic Symptoms in a Psychiatry Department: A Case Report

Vitamin B12 Deficiency Presenting as Psychotic Symptoms in a Psychiatry Department: A Case Report

Does vitamin B12 deficiency explain psychiatric symptoms in recreational nitrous oxide users? A narrative review

Advancing Neuroprotective-Based Treatments for Schizophrenia

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PSYCHIATRIC SYMPTOMS DUE TO VITAMIN B 12 DEFICIENCY WITHOUT ANAEMIA

Cited by 11 publications

References 6 publications

Vitamin B12 Deficiency Presenting as Psychotic Symptoms in a Psychiatry Department: A Case Report

Vitamin B12 Deficiency Presenting as Psychotic Symptoms in a Psychiatry Department: A Case Report

Does vitamin B12 deficiency explain psychiatric symptoms in recreational nitrous oxide users? A narrative review

Advancing Neuroprotective-Based Treatments for Schizophrenia

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Product

Resources

About

PSYCHIATRIC SYMPTOMS DUE TO VITAMIN B ₁₂ DEFICIENCY WITHOUT ANAEMIA