Psychiatric symptoms in systemic lupus erythematosus: an update.

Wekking, Ellie M.

doi:10.1097/00006842-199303000-00011

Cited by 111 publications

(83 citation statements)

References 36 publications

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“…Previous studies have shown that these patients have lower physical capacity, increased fatigue and poorer quality of life compared to healthy population (Krupp et al 1990;Wekking 1993;Dobkin et al 1999;Bruce et al 1999;Iverson et al 2001;Stoll et al 2001;Tench et al 2002Tench et al , 2003Jolly 2005;Stojanovich et al 2007), each of which is a possible consequence of fatigue, depressed behavior, obesity and association with other autoimmune diseases, such as fibromyalgia, diabetes, and thyroid function disorder (Petri et al 1992;Svenungsson et al 2001;Bruce et al 2003;Oeser et al 2005;Urowitz et al 2008;Goldberg et al 2009). According to current literature, patients with SLE may benefit from exercise through prevention of cardiovascular and cerebrovascular diseases (Cronin 1988;Ayan and Martin 2007;Mancuso et al 2011).…”

Section: Discussionmentioning

confidence: 99%

“…Although it has been long considered a consequence of the activity of disease itself, it is clear today that it has a multifactorial origin. The cause of fatigue is not completely understood, and it is believed that it may be a result of the disease itself as well as sleep disorders and/or depressive behavior, glucocorticoids and immunounosuppressive drugs and obesity (Krupp et al 1990;Wekking 1993;Bruce et al 1999;Stoll et al 2001;Oeser et al 2005). The presence of fatigue is one of the important parameters of numerous tests used to evaluate the activity of the disease itself (Krupp et al 1991).…”

Section: Discussionmentioning

confidence: 99%

“…Also the depression in these patients may be associated with dysfunction of the thyroid, chronic pain, fatigue, and the adverse effect of corticosteroid therapy, the changed lifestyle (inability to fulfill the social, family and professional obligations) (Wekking 1993;Iverson et al 2001;Stoll et al 2001;Stojanovich et al 2007). The degree of psychological disorders ranges from light melancholy to a severe feeling of sadness.…”

Section: Discussionmentioning

confidence: 99%

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Physical Activity Program Is Helpful for Improving Quality of Life in Patients with Systemic Lupus Erythematosus

Bogdanović

Stojanovich

Djoković

et al. 2015

Tohoku J. Exp. Med.

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Given the crucial events in systemic lupus erythematosus (SLE) such as joint and muscle pain, fatigue, depression, obesity and osteoporosis, the very thought of exercising can be challenging. This prospective study included 60 patients diagnosed with SLE in stable condition. A randomly selected group of 30 women had aerobic training on a bicycle ergometer for a period of 15 minutes, 3 times per week for 6 weeks, while the second group of 30 women performed isotonic exercises (to stretch and lengthen muscles and improve the range of motion) for 30 minutes, 3 times per week during the same period. Fatigue Severity Scale (FSS), Short Form 36 (SF36) questionnaire on the quality of life and Beck depression inventory (BDI) were analyzed at baseline and after 6 weeks. At baseline FSS score was 53.8 ± 5.7 and after the physical activity FSS score was 29.1 ± 7.8 (FSS ≥ 36; fatigue is present). The largest number of patients (66.7%) was in a moderate depressed state at the baseline, while after physical activities 61.7% of patients, had a mild mood disturbance. There were significant differences (p < 0.001) in values of all areas of quality of life questionnaire SF36 before and after the implementation of physical activity. The type of physical activity had no influence in FSS and BDI values. Continuous physical activity, regardless of its type, significantly improved quality of life of SLE patients. We recommend regular physical activity as an integral part of modern therapeutic approach in this patient population.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Physical Activity Program Is Helpful for Improving Quality of Life in Patients with Systemic Lupus Erythematosus

Bogdanović

Stojanovich

Djoković

et al. 2015

Tohoku J. Exp. Med.

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“…Increased intracranial pressure can arise from a hypercoagulability state or thrombosis within the cerebral venous system (Vidailhet et al 1990;West 1994). Psychosis is well known in SLE and can indirectly influence cognitive performance (Wekking 1993;Wekking et al 1991). While these and other transient or fluctuating processes are clinically important, it is the underlying cerebral disease which is of most relevance for the neuropsychology researcher.…”

Section: Cerebral Pathology In Slementioning

confidence: 99%

Neuropsychological Impairment in Systemic Lupus Erythematosus: A Comparison with Multiple Sclerosis

et al. 2008

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In this manuscript, we review literature describing the neuropsychological and brain imaging characteristics of systemic lupus erythematosus (SLE) patients. The findings are compared and contrasted with multiple sclerosis (MS) studies, revealing similarities and differences of interest to clinicians and researchers. While cognitive impairment is somewhat less common in SLE than MS, the diseases share a similar cognitive profile with deficits most prominent on tests emphasizing the speed of information processing, working memory, and visual/spatial learning, and memory. In early or more mildly affected patients, diffuse white matter damage, which may not be apparent on conventional brain imaging, plays a major role in clinical presentation and cognitive testing. The causes of white matter damage are very different, however, and in later stages of the disease MS and SLE appear to give rise to different forms of cerebral pathology. MS may be characterized by increasing brain atrophy affecting especially the cortical and deep gray matter, at least after conversion to secondary progressive course. There is less evidence for neurodegenerative changes in SLE, but patients are increasingly at risk for cerebrovascular disease. We conclude by offering some suggestions for future clinical and imaging research. KeywordsSystemic lupus erythematosus; Multiple sclerosis; Cognition; Memory; Processing speed; MRI; Effect size Systemic lupus erythematosus (SLE) is a relapsing-remitting autoimmune disease with wide ranging organ involvement and clinical symptoms varying from mild and transient symptoms to death. Cognitive impairment is reported in SLE, even among those patients without documented or overt signs of central nervous system (CNS) involvement. Presumably, cognitive disorder is the result of underlying brain disease although the precise mechanisms remain to be elucidated. The prevalence and degree of cognitive impairment is also uncertain.In this article we will endeavor to evaluate the evidence for neuropsychological impairment in SLE, and to compare the findings with that of MS, another immunological disorder whose symptoms wax and wane and which affects women more than men. Unlike SLE, MS is a disease that always impacts the CNS, and the causes of cognitive disorder in MS are better understood.

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“…El trastorno observado con mayor frecuencia fue la depresión, que se reportó entre 2% y 54% de los enfermos. Estas diferencias se atribuyeron a la diversidad en los instrumentos utilizados para la detección de depresión 8 .…”

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