Psycho-Emotional and Behavioral Problems in Children With Growth Hormone Deficiency

Aryayev, M.L.; Senkivska, L. I.; Lowe, John B.

doi:10.3389/fped.2021.707648

Cited by 4 publications

(4 citation statements)

References 26 publications

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“…High anxiety prevents patients from abandoning an unhealthy lifestyle and eating habits, which significantly hinders success in reducing body weight. The obtained results correspond to international data on changes in the psycho-emotional state of children with chronic diseases [2,12].…”

Section: Results Of the Research And Discussionsupporting

confidence: 83%

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Anxiety level in overweight and obese children

Aryayev,

Selimkhanova,

Shevchenko

2023

UJPP

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Purpose - to evaluate personal and situational anxiety levels in overweight and obese children. Materials and methods. 153 children (72 girls and 81 boys) aged 12-17 were involved in the study at the Odesa Regional Children’s Clinical Hospital. Anthropometric indicators (weight, height, body mass index (BMI)) were assessed taking into account the sex and age of children. Based on BMI values, 3 groups were selected: 1 - children with a body weight corresponding to age and gender - 47 persons (Control); 2 - children with excessive body weight - 50 persons (Overweight); 3 - children with obesity - 56 persons (Obesity). The state of personal and situational anxiety was determined using the Spielberger-Khanin questionnaire. Statistical data analysis was carried out using packages STATISTICA 12.0, MedCalc 20.0, Microsoft EXCEL 2003. Results. In children with obesity, the most common comorbidities were biliary dyskinesia (14.28%), arterial hypertension (10.52%), skin infections 4% and obstructive sleep apnea syndrome 2%. In the studied groups of children, the level of anxiety increased in proportion to the degree of increase in body weight. Personal anxiety in children with obesity compared to control was noted at a higher level - 50.1±1.04 and 30.27±0.98, respectively (χ2=49.9, p=0.0001). Situational anxiety also increased in children with obesity, but the differences were expressed to a lesser extent - 38.94±0.74 and 33.91±0.93 (χ2=5.49, p=0.019). Conclusions. The obtained results indicate the feasibility of further study and monitoring of the psycho-emotional state and quality of life of overweight and obese children and adolescents for individual psychological support and correction of psycho-emotional disorders. The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of participating institution. The informed consent of the patient was obtained for conducting the studies. No conflict of interest was declared by the authors.

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Section: Results Of the Research And Discussionsupporting

confidence: 83%

“…SA=Σсп-Σсо+50, where SA is an indicator of situational anxiety; Σsp -the sum of points for direct questions (3,4,6,7,9,12,14,15,17,18); Σso is the sum of points for oppositely polar questions (1,2,5,8,10,11,13,16,19,20).…”

Section: Materials and Methods Of The Researchmentioning

confidence: 99%

Anxiety level in overweight and obese children

Aryayev,

Selimkhanova,

Shevchenko

2023

UJPP

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“…The effectiveness of rhGH therapy was assessed taking into account the dynamics of psychological problems, changes in the QoL, and decrease in self-esteem, which were previously identified in children with GHD [6]. The positive effect of rhGH in children with GHD was confirmed by a decrease in the severity of psycho-social problems according to the SDQ scale.…”

Section: Resultsmentioning

confidence: 99%

“…In this regard, it is important to clarify the controversial and insufficiently studied role of exon d3/fl polymorphism of the growth hormone receptor in modulating the response to replacement therapy [4,5]. Important criteria for evaluating the results of therapy with exogenous growth hormone can be not only the growth response, but also psychosocial and behavioural problems, which change significantly in children with GHD [6]. Researchers are trying to fill the gap in our knowledge about the association between the psychoemotional state, and self-esteem, quality of life (QoL) in children with GHD and height velocity as well as the correlation between clinical parameters, d3-GHR genotype, and growth response to rhGH.…”

Section: Introductionmentioning

confidence: 99%

Growth response, psychosocial problems, and quality of life in children with growth hormone deficiency

Aryayev¹,

Senkivska²

2022

polp

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Aim:To establish an association between growth response to recombinant human growth hormone (rhGH) therapy and clinical and anthropometric parameters, d3-GHR polymorphism, psychosocial problems, and quality of life (QoL) in children with growth hormone deficiency (GHD). Material and methods:The study included 46 prepubescent children with GHD and 80 healthy prepubescent children. To analyse growth re-sponse predictors for the rhGH therapy, a number of clinical and anthropometric parameters were selected. The poly-morphism of exon 3 of the GHR gene was determined using multiple PCR amplification. Psychosocial functioning was assessed by the Strengths and Difficulties Questionnaire. The self-esteem was studied by the Dembo-Rubinstein method. The QoL was determined using the Peds QL4.0 questionnaire. Assessment of differences between the mean values of 2 independent variation series by the value of p was performed. The relationship between predictors and growth response was assessed using the Spearmen coefficient of correlation. Results: An association was found between height velocity (HV) (cm/yr; SDS) and chronological age, compliance, birth weight, height, height (SDS)-MPH (SDS), weight, peak GH response, rhGH dose, and d3-GHR/fl/l-GHR. The results suggest that the d3-GHR explains the better responsiveness to the rhGH therapy only for the first but not for the second year. The rhGH therapy leads to an improvement in the psychoemotional state, QoL, and self-esteem of children. Conclusions: HV at the start of therapy, acceptable compliance, birth weight, growth at the start of therapy, height (SDS) -MPH (SDS), weight at the start of therapy, peak growth hormone response, and genotype d3-GHR are associated with the growth response to rhGH therapy. During the first and second years of therapy, a positive effect on the psychoemotional state, quality of life, and self-esteem of children with GHD was noted.

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Association between the Uric Acid to High Density Lipoprotein Cholesterol Ratio and Systolic Pressure in Chinese Short Stature Children and Adolescents

李¹

2022

ACM

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Psycho-Emotional and Behavioral Problems in Children With Growth Hormone Deficiency

Cited by 4 publications

References 26 publications

Anxiety level in overweight and obese children

Anxiety level in overweight and obese children

Growth response, psychosocial problems, and quality of life in children with growth hormone deficiency

Association between the Uric Acid to High Density Lipoprotein Cholesterol Ratio and Systolic Pressure in Chinese Short Stature Children and Adolescents

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