Psycho-socio-clinical profiles and quality of life in seizure disorders: A cross-sectional registry study

Kastell, Shirley-Uloma; Hohmann, Louisa; Holtkamp, Martin; Berger, Justus

doi:10.1016/j.yebeh.2022.108916

Cited by 3 publications

(2 citation statements)

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“…In addition, the generalizability of our findings should be tested in out‐patient samples. Ambiguous findings of previous studies comparing SCI of patients with epilepsy and PNES 52,53 indicate that also a comparison with this patient group may be an interesting topic of future research.…”

Section: Discussionmentioning

confidence: 96%

Subjective cognition is linked to everyday functioning in epilepsy

et al. 2023

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Section: Discussionmentioning

confidence: 96%

Subjective cognition is linked to everyday functioning in epilepsy

et al. 2023

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“…Mood disorders affect people with epilepsy at several levels: (i) they impact management as they are associated with an increased risk of treatment-resistant epilepsy and of a higher incidence of iatrogenic psychiatric and non-psychiatric adverse events associated with antiseizure medications (ASMs) [ 5 , 6 ]; (ii) they are associated with an increased risk of premature mortality, resulting from a higher occurrence of completed suicide, and of death associated with other external causes [ 7 ]; (iii) they increase costs to individuals, families and society through greater use of medical services [ 8 ]; (iv) among people with treatment-resistant focal epilepsy, depressive symptoms are one of the leading independent predictors of poor quality of life more than seizure frequency and severity [ 9 ]. Mood disorders can also negatively impact people with reasonable seizure control and in an advantaged socioeconomic situation [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Mood disorders in adults with epilepsy: a review of unrecognized facts and common misconceptions

Kanner,

Shankar,

Margraf

et al. 2024

Ann Gen Psychiatry

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Epilepsy is one of the most common neurologic conditions. Its clinical manifestations are not restricted to seizures but often include cognitive disturbances and psychiatric disorders. Prospective population-based studies have shown that people with epilepsy have an increased risk of developing mood disorders, and people with a primary mood disorder have an increased risk of developing epilepsy. The existence of common pathogenic mechanisms in epilepsy and mood disorders may explain the bidirectional relation between these two conditions. Recognition of a personal and family psychiatric history at the time of evaluation of people for a seizure disorder is critical in the selection of antiseizure medications: those with mood-stabilizing properties (e.g., lamotrigine, oxcarbazepine) should be favoured as a first option in those with a positive history while those with negative psychotropic properties (e.g., levetiracetam, topiramate) avoided. While mood disorders may be clinically identical in people with epilepsy, they often present with atypical manifestations that do not meet ICD or DSM diagnostic criteria. Failure to treat mood disorders in epilepsy may have a negative impact, increasing suicide risk and iatrogenic effects of antiseizure medications and worsening quality of life. Treating mood disorders in epilepsy is identical to those with primary mood disorders. Yet, there is a common misconception that antidepressants have proconvulsant properties. Most antidepressants are safe when prescribed at therapeutic doses. The incidence of seizures is lower in people randomized to antidepressants than placebo in multicenter randomized placebo-controlled trials of people treated for a primary mood disorder. Thus, there is no excuse not to prescribe antidepressant medications to people with epilepsy.

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