“…An important question, therefore, is what factors or mechanisms predispose for, or predict, drug choice. More specific hypotheses about psychological factors, the self-medication notion for instance (Khantzian, 1985), have been under rather intensive critique (e.g., Dackis & Gold, 1986;Ghaffari, 1987;Goldsmith, 1993;Greene, Adyanthaya, Aravind, Morse, & Davis, 1993;Khantzian, 1986;Miller & Gold, 1991). One might even argue that specific hypotheses are premature until the more general hypothesis has been substantiated that personality or other psychological factors or mechanisms are at all accountable.…”