Psychobiological differences between depression and somatization

Rief, Winfried; Hennings, Anika; Riemer, Sabine; Euteneuer, Frank

doi:10.1016/j.jpsychores.2010.02.001

Cited by 72 publications

(41 citation statements)

References 86 publications

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“…As values fluctuated significantly only in the MD group, an influence of this disease on the immune system also seems possible. Several studies have found characteristic alterations in the immune status of depressed persons [10, 11, 32, 47], suggesting a proinflammatory immune status in these patients. The female MD subgroup showed highly significant fluctuations in activated T lymphocytes (CD3 + CD25 + ), which is also an indicator of inflammation, once more suggesting an altered and possibly more fragile cellular immune status in depressed patients.…”

Section: Discussionmentioning

confidence: 99%

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Stability of Cellular Immune Parameters over 12 Weeks in Patients with Major Depression or Somatoform Disorder and in Healthy Controls

Krause

Stapf

Kirnich

et al. 2018

Neuroimmunomodulation

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Objective: Cellular immune status in major depression (MD) patients differs from that in somatoform disorder (SFD) patients and healthy controls (HC). It is still questionable whether the patterns of immune parameters remain stable over time. Therefore, we studied lymphocyte and monocyte cell counts and neopterin levels in peripheral blood of MD and SFD patients and HC over 12 weeks and tested for correlations between biochemical and psychometric parameters. Methods: Thirty-nine patients with MD, 27 with SFD, and 51 HC were recruited. Peripheral blood was drawn at four visits, at 4-week intervals. We assessed the total cell count of B lymphocytes, natural killer (NK) cells, T lymphocyte subpopulations, and monocytes by flow cytometry, and neopterin serum levels by ELISA. Psychometric parameters were measured with questionnaires. Results: Counts of lymphocytes, monocytes, and neopterin were stable in the SFD and HC groups. In the MD group, total CD3⁺, CD3⁺CD8⁺, NK cells, and CD3⁺CD25⁺ T cells showed inhomogeneous variances in Friedman tests, particularly in females. Neopterin correlated with depressed mood in MD patients, and with body mass index in HC. Conclusions: Cellular immune parameters are stable in HC and SFD. Our results may indicate influences of MD and gender on some cellular immune parameters. This may need to be considered in future immunological studies.

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Section: Discussionmentioning

confidence: 99%

“…There are indications that the immune system may be causally involved, but study results vary [8-10]. Taking all these findings together, it is further strengthened that depression and SFD are two frequently overlapping clinical conditions having both been related to immunological changes [11]. …”

Section: Introductionmentioning

confidence: 99%

Stability of Cellular Immune Parameters over 12 Weeks in Patients with Major Depression or Somatoform Disorder and in Healthy Controls

Krause

Stapf

Kirnich

et al. 2018

Neuroimmunomodulation

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“…There is no general etiological model for somatization phenomena (Rief and Broadbent, 2007). However, interesting neurobiological studies demonstrate that patients with somatization disorder may have an abnormality in cortical and neuropsychological functioning, e.g., bifrontal impairment of the hemispheres, abnormal auditory-evoked potentials, and abnormal levels of cortisol (Rief et al, 2010;Tak and Rosmalen, 2010). Several etiological conditions play a prominent role, especially in maintaining the process and can be considered as empirically derived risk factors (see Figure 1).…”

Section: Etiology and Coursementioning

confidence: 99%

Somatoform Disorders

Angenendt¹,

Härter²

2015

International Encyclopedia of the Social &Amp; Behavioral Sciences

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Somatoform disorders, or somatic symptom disorder, as it is denominated in Diagnostic and Statistical Manual of Mental Disorders, fifth edition, are a heterogeneous group of mental health problems that are characterized by enduring bodily complaints and symptoms that are not due to organic dysfunction or disease. These patients perceive a wide range of severe symptoms like pain, gastrointestinal, cardiovascular, sexual, and/or pseudoneurological symptoms, which cause permanent attention, worry, and distress. They excessively seek medical help and reassurance, but have difficulties accepting the nonpathological results in medical examinations. The concept of psychological and psychosocial influences and causes is rejected, and mental health services are usually not attended. Biological, psychological, and psychosocial factors interact as precipitating, triggering, and maintaining factors of psychopathology. The different subtypes (somatization, conversion, pain disorders, hypochondriasis, and dysmorphophobia) are described with their central features: clinical presentation, epidemiology, comorbidity, and course. Current etiological and pathogenic models are introduced as a clinical and theoretical basis for therapeutic interventions. Besides general psychotherapeutic principles more specific interventions addressing the modification of subjective health-beliefs, illness behaviors, and coping skills are described. The clinical significance of somatoform disorders stresses the need for training programs to provide and improve basic diagnostic and therapeutic skills, especially in primary care. Future directions for the management of these disorders are outlined.

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“…74 La responsabilité de cette baisse de la réponse en cortisol est évoquée dans l'apparition de multiples phénomènes pathologiques : douleurs diffuses (McBeth, 2005 ;McBeth, 2007 ;Tops, 2008), syndrome de fatigue chronique, fibromyalgie, troubles somatoformes ou troubles fonctionnels somatiques (Heim, 2000 ;Rief, 2010 ;Pukhalsky, 2008 ;Tak, 2010 ;Riva, 2010 ;Tak, 2011 77 Judith Gold (2006) fournit aussi des éléments en faveur de cette thèse. Elle met en évidence, chez les ouvriers de l'automobile, une relation entre le seuil de la douleur à la pression, évalué sur douze zones du corps, et la présence d'un trouble musculosquelettique des membres supérieurs.…”

Section: Les Phénomènes Pathologiques Associésunclassified

Souffrance au travail, répression psychique et troubles musculo-squelettiques

Davezies¹

2013

pistes

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Psychobiological differences between depression and somatization

Cited by 72 publications

References 86 publications

Stability of Cellular Immune Parameters over 12 Weeks in Patients with Major Depression or Somatoform Disorder and in Healthy Controls

Stability of Cellular Immune Parameters over 12 Weeks in Patients with Major Depression or Somatoform Disorder and in Healthy Controls

Somatoform Disorders

Souffrance au travail, répression psychique et troubles musculo-squelettiques

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