Psychobiotic Therapy: Method to Reinforce the Immune System

Abstract

Psychobiotics are probiotic microorganisms that beneficially affect the central nervous system functions mediated by the gut-brain axis, improving the host's immune system. Psychobiotic microorganisms can regulate brain pathways and serotonin production (mood controller). The main microbial genera with psychobiotic characteristics are Lactobacillus, Lactococcus and Bifidobacterium. The daily consumption of psychobiotics is called "Psychobiotic Therapy". Psychobiotic therapy has proven antidepressant/anxiolytic properties. Psychobiotic therapy can be used to boost the host's immune balance against pathogens, for example: virus, bacteria and fungus. Thus, psychobiotic therapy can be a promising strategy to improve and/or maintain the quality of life of people who are healthy or who suffer from anxiety/stress disorders, intestinal dysbiosis and even immunosuppressed people. This is such a hot theme it can surely only be a matter of time for psychobiotic therapy offers an "alternative treatment", but scientific, for people diagnosed with a variety of mental/immunological disorders. Instead of targeting the mind (brain), we could go for the gut. "This new way of looking at mental health linked to gut health is literally looking at health upside down".

Generally-healthy individuals with aberrant bowel movement frequencies show enrichment for microbially-derived blood metabolites associated with reduced kidney function

“…The gut microbiome influences human health in a number of ways, from mediating early life immune system development [1,2], to determining personalized responses to nutritional interventions [3,4] and influencing the central nervous system [5,6]. Stool transit time, defined as the rate at which stool moves through the gastrointestinal tract, is a major determinant of the composition of the human gut microbiota [7].…”

Prolonged Lifespan, Improved Perception, and Enhanced Host Defense of Caenorhabditis elegans by Lactococcus cremoris subsp.cremoris

“…Since biogenic amines, such as serotonin, could be involved in the antisenescence effects of probiotic bacteria ( 10 , 39 ), live FC modifies the number of monoamines absorbed and influences senescence through the so-called gut-brain axis ( 40 ). FC might function as a psychobiotic bacterium in worms ( 41 ). Although it remains uninvestigated whether the organisms can produce bioactive amines, another probiotic, Bifidobacterium dentium , has been reported to stimulate serotonin synthesis in chromaffin cells ( 42 ).…”

Probiotics: Bridging the interplay of a healthy gut and psychoneurological well‐being

“…In response to inflammatory stimuli, the HPA axis secretes corticotropin‐releasing hormone (CRH) and adrenocorticotrophic hormone (ACTH). These hormonal substances are essential for starting immunological reactions against various microbes such as viruses (Oroojzadeh et al, 2022), bacteria (Salem et al, 2022), and fungi (Magalhães‐Guedes, 2022). Prior studies have shown that CRH can increase the permeability of the intestines and increase levels of ACTH in the circulation when there is neuronal stress.…”